Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Pro-opiomelanocortin"”.
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Growing Up POMC: Pro-opiomelanocortin in the Developing Brain
… of signals related to energy status by Pro-opiomelanocortin (POMC) and Neuropeptide-Y/agouti-related protein (NPY/AgRP) neurons in the ARH exert opposing influences on secondary neurons in central circuits regulating energy balance. My thesis research focused on the developmental events …
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Effects of single nucleotide polymorphisms in leptin and pro-opiomelanocortin on peripheral eucocyte counts in beef cattle
… polymorphisms (SNP) in leptin (LEP) and pro-opiomelanocortin (POMC) have been associated with beef carcass quality and yield respectively. Both hormones also play a role in immune performance. Since both of these genes are pleiotrophic, it was important to determine whether selection …
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Regulation of secretion of pro-opiomelanocortin-derived peptides from the pars intermedia of the amphibian xenopus laevis
Contains fulltext : mmubn000001_043491480.pdf (Publisher’s version ) (Open Access)
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Effects of exogenous and endogenous factors on appetite regulation in broiler chicks and Japanese quail
… to animal agriculture in order to maximize production capabilities, as well as in human medicine to generate ways to treat conditions such as eating disorders or obesity. The aim of this thesis was to evaluate the effects of ferulic acid (FA), an exogenous factor found within plant cells, …
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Involvement of AMP-activated protein kinase in differential regulation of appetite between lines of chickens selected for low or high juvenile body weight
… has altered the hypothalamic AMP-activated protein kinase (AMPK) system and (2) if this alteration contributes to the dissimilar feeding response to various appetite modulators between HWS and LWS lines. Compared to HWS, LWS chickens had higher levels of AMPK α and acetyl-CoA carboxylase …
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Investigation into the immuno-therapeutic potential of melanocortin peptides on activated chondrocytes
Melanocortin peptides are endogenously produced peptides originating from the posttranslational processing of the pro-opiomelanocortin hormone (POMC), exerting their effect by binding to class A G-protein-coupled 7 transmembrane domain receptors, positively coupled to adenylate cyclase. To date …
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Melanocortin Peptides Coordinate Metabolic and Immune Responses
Pages 84-114 are misnumbered as pages 83-113.
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Ion channels and electrical excitability in native murine anterior pituitary corticotrophs
… implicated in the control of their electrical properties and ACTH secretion. However, the mechanisms involved in native corticotrophs are poorly understood partly due to the current limitations of identifying physiological intact corticotrophs. To address the electrophysiological properties of …
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Modelling altered Glucocorticoid Sensitivity: From HPA axis to metabolic abnormalities in mice and humans
… cassette was fused with GR. The resulting fusion protein lacks part of the DNA binding domain and the entire ligand binding domain and is transcriptionally inactive. In addition, the beta-galactosidase enzyme activity “reports” activity of the GR gene promoter. GR-/- mice are present in a normal …
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Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes
… system, comprised of melanocortin peptides could provide a novel treatment option for OA. Melanocortin peptides are endogenous pro-opiomelanocortin-derived peptides that display potent anti-inflammatory effects via the activation of the 7-transmembrane Gprotein coupled melanocortin receptors. To …
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Molecular and Physiological Adaptations to Weight Perturbation in Mice
… such individuals, this is an imprecise approach since the critical levels of adiposity in this regard differ substantially among individuals. Our common genetic predisposition to increased adiposity, coupled with an environment conducive to positive energy balance results in an increasing …
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The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
… of SNS innervation of adipose tissue to promote fat usage. We first visualized SNS innervation, using a whole-mount tissue clearing method (Adipo- Clear) paired with light sheet microscopy imaging, in both brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) of wild-type …