Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Pro-inflammatory response"”.
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Thymoquinone is a Novel Ligand which Activates Neu4 Sialidase to Promote a Pro-Inflammatory Response
… and prevention. TQ is believed to share similar properties to the benzoquinones already in use as therapeutic drugs. Based on previous reports on the anti-inflammatory properties of black seed oil and TQ, it was originally hypothesized that TQ would inhibit lipopolysaccharide (LPS)-induced …
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Development Of New Therapy to Combat Tuberculosis Induced Inflammation
Tuberculosis (TB) is a major global health problem. TB disease induces a strong pro-inflammatory response, which can lead to irreversible lung damage, even after successful antibiotic therapy. This thesis investigated the effectiveness of two anti-inflammatory agents, Tristetraprolin (TTP) and …
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THE ANTI-INFLAMMATORY AND PRO-NEUROGENIC ROLE OF PPARα IN MODULATING RADIATION-INDUCED BRAIN INJURY
… to minimize WBI-induced morbidity. Peroxisomal proliferator-activated receptors (PPARs) are ligand-activated transcription factors that possess anti-inflammatory properties. We hypothesize that activation of PPARα will prevent radiation-induced brain injury, in part, by inhibiting the …
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Endothelial cell response to bioactive peptides and stiffened extracellular matrices: an investigation into atherogenic pathways
… This dysfunction can be mitigated by cardioprotective signaling molecules such as nitric oxide (NO) which can be upregulated in the presence of bioactive milk peptides. An investigation into the NO liberating capacity of select bioactive peptides was performed on cultures of Human Umbilical …
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Oral epithelium in the pathogenesis of periodontitis
… cell line (H400) in order to investigate responses to periodontal pathogen stimulation (P. gingivalis and F. nucleatum) in terms of NF-\(\kappa\)B activation, differential gene expression and cytokine production. The pathogenesis of periodontitis suggests that susceptible patients exhibit …
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The effects of hyaluronic acid and exercise on equine skeletal muscle
… muscle damage that subsequently induces an acute inflammatory response in the tissue which is marked by an infiltration of leukocytes into the damaged muscle. To try and suppress the initial pro-inflammatory response in skeletal muscle of horses performing a single exercise stress test, a …
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Energy Balance, Immune System Function, and Susceptibility to Mastitis in Dairy Cows
The studies proposed for this dissertation evaluate the relationship between energy status and immune system function at the whole animal, protein, and genomic levels, as well as via the utilization of a large-scale epidemiological dataset. Our large-scale study indicated the potential use of …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
… inflammation. We observed greater pathology, inflammatory influx, and increased pro-inflammatory cytokines (e.g. IL-1, TNF) in co-infected HuMouse lung. Using primary human monocyte-derived macrophages (MDM) and an in vitro co-infection system, we further observed greater cell death and …
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The Role of Inflammation in the Pathobiology of TB/HIV Co-infection
… inflammation. We observed greater pathology, inflammatory influx, and increased pro-inflammatory cytokines (e.g. IL-1, TNF) in co-infected HuMouse lung. Using primary human monocyte-derived macrophages (MDM) and an in vitro co-infection system, we further observed greater cell death and …
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Influence of Peripheral Immune-Derived EphA4 on Microglial Dynamics Following Traumatic Brain Injury
… brain injury (TBI) elicits an immediate neuroinflammatory response that involves resident glia and infiltrating peripheral immune cells that coordinate tissue damage and functional deficits. The activation of resident microglial has been associated with a change in their morphology from a …
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Epigenetic Regulation of Skin Development and Postnatal Homeostasis The role of chromatin architectural protein Ctcf in the control of Keratinocyte Differentiation and Epidermal Barrier Formation
… described previously. Chromatin architectural protein Ctcf has previously been implicated in the control of long-range enhancer-promoter contacts and inter-chromosomal interactions. Ctcf is broadly expressed in the skin including epidermal keratinocytes and hair follicles. Conditional Keratin …
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Distinct Functional Properties of Perinatal Versus Adult Adipose Progenitor Subpopulations
… distinct subpopulations of PDGFRβ+ perivascular progenitor cells within adult WAT depots that differentially impact tissue remodeling in obesity. PDGFRb+ APCs contribute to adipocyte hyperplasia associated with diet-induced obesity, whereas PDGFRb+ fibro-inflammatory progenitors, or "FIPs," …
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Investigation of the Serological Changes that Discriminate Asymptomatic Antinuclear Antibody Positive Individuals from Systemic Autoimmune Rheumatic Disease Patients
… and prevent further damage by lessening the inflammatory immune response through broad and often aggressive immunosuppression, which leaves patients vulnerable to numerous side effects. Although ANAs are a serological hallmark for the ANA-associated SARD, they are also seen in healthy …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
Crohn’s disease (CD) is a chronic inflammatory disorder characterized by an aberrant inflammatory response against a dysbiotic gut microbiota. Especially, intestinal enrichment of the adherent-invasive Escherichia coli strain (AIEC), together with a dysregulated activation of the IL-23/pTh17 axis, …
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Entamoeba histolytica-Induced Caspase-4 Activation Regulates IL-1β Secretion Through Caspase-1
… invasion, Eh encounter macrophages in the lamina propria and this intricate host-parasite interaction is critical in eliciting a tissue damaging raging pro-inflammatory response. When Eh binds macrophages via the Gal-lectin, surface EhCP-A5 ligates α5β1 integrin to activate caspase-1 in a complex …
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The role of BCAP in regulating the TLR signalling pathway
… immunity against microbial infections. Their pro-inflammatory signal transduction typically involves the oligomerisation of downstream TIR-domain-containing adaptors MAL and MYD88. BCAP (B-cell adapter for PI3K) was identified as a negative regulator in the TLR4 MYD88-dependent signalling …
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Cellular Reprogramming in Skeletal Muscle after Repeated Exposures to Endotoxin
… immune system receptor, due to its role in proinflammatory pathways. Lipopolysaccharide (LPS), a gram-negative bacteria cell wall component, is the ligand for TLR4, and has been shown to be elevated in states of metabolic disease. Heightened levels of circulating endotoxin is termed …
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A novel particle-based in situ gelling system for delivering hydrogen sulfide at a sustained rate for potential application in glaucoma and retinal neurodegeneration
… ion channel regulation, cardiovascular protection, and anti-oxidation effects. One of the most important therapeutic potential lies in the treatment and management of glaucoma, a condition which is characterized by elevated intraocular pressure (IOP) and neurodegeneration of retina …
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All- trans-retinol modulation of chemically-induced pulmonary and hepatic toxicity
… in the lung it has been shown that retinol can protect against many of the inflammatory effects caused by bleomycin. Whether or not retinol pretreatment can modulate chemical-induced injury of compounds that cause both liver and lung toxicity is unknown. Therefore, the studies presented here …
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Characterization of a Nanoparticle Drug Delivery System for the Treatment of Inflammation in Spinal Cord Injury
… So, in order to counteract this deleterious pro-inflammatory response, we decided to maximize the efficacy of a well-known anti-inflammatory drug, minocycline, through a NPs delivery tool selectively targeted to microglia/macrophage. We developed and tested a new drug delivery nanocarrier …
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