Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Principal Cell"”.
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
… study was the analysis of the role of renal principal cell MR, which is activated by aldosterone, in ENaC-mediated sodium reabsorption. For this purpose, mice deficient for MR in ENaC-expressing renal principal cells were generated using the Cre-loxP recombination system. A large fragment of …
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Pharmacological Intervention Reduces Hippocampal Hyperactivity in a Mouse Model of Psychosis
… one week after DG inhibition by quantifying principal cell activity in hippocampal subfields. The CA3 and CA1 were hyperactive compared to control mice. The effects of acute drug administration were assessed: all drugs tested showed robust decrease of baseline CA3 and CA1 hyperactivity …
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Understanding and targeting network-level sheddase regulation in invasive disease
Regulated cell-surface proteolysis underpins key processes of cellular growth and motility in both physiological and pathological contexts. However, comprehending how multiple proteolytic events cohesively integrate to yield context-dependent cellular behavior remains a challenge in the fields of …
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Modulation of Signal Transduction in the Nervous System by Protein Phosphorylation
… transduction, the process by which an extracellular signal is translated into an intracellular message, underlies all brain function. This thesis examines the role of protein phosphorylation in mediating three different molecular mechanisms by which neurotransmitter receptors transduce their …
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Investigating the role of rare genetic variants in the aetiology of haemostasis disorders
… experiments to define the most detailed cell type-specific maps of interactions between promoters and regulatory elements for the 93 diagnostic-grade genes for haemostatic diseases. To obtain these interaction landscapes, I differentiated human induced pluripotent stem cells from the …
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A blood exchange method to study circulation kinetics of tumor cells in the blood
Blood is an essential compartment for tumor cell trafficking. In solid epithelial-derived tumors, blood serves as the major vehicle for metastasis, whose principal cell is the circulating tumor cell (CTC). These cells originate from the primary tumor and are shed at low concentrations into the …
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Tracking The Flow of Information Through The Hippocampal Formation In The Rat
… neurons in the dentate gyrus were examined. The principal cell of the dentate gyrus, the granule cell, has spatially selective place fields; however, the behavioral correlates of another excitatory cell, the mossy cell of the dentate polymorphic layer, are unknown. This report shows that putative …
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Endogenous modulators of hyperexcitability in epilepsy: electrophysiological and optogenetic delineation of neuropeptide Y mechanisms in interneurons
… about the effect NPY has on GABAergic inhibitory cell populations, and NPY mechanisms of action have to be carefully determined if such an approach could be used in humans. There are several different subtypes of inhibitory cell populations in all cortical areas, and each of them serve a different …
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Developmental Origins of Renal Connecting Tubule and Collecting Duct: Role of Aqp2+ Progenitor Cells
… networks. The collecting duct is comprised of principal cells and intercalated cells, which bear different molecular signatures and regulate sodium/water and acid/base balance, respectively. The progenitor cells of the connecting tubule and the collecting duct remain virtually unknown.</p> …
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Virulence and pathogenic mechanisms of <i>Legionella pneumophila</i>
… were found. The lipopolysaccharide and extracellular enzyme activities of the pairs of strains were indistinguishable. <br></br><br></br>The Corby strain of <i>L.pneumophila</i>(CV) was isolated from its intracellular <i>in vivo</i> environment and these bacteria compared with the same strain …