Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Prime-boost"”.
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
Mice immunized with a 2-dose strategy utilizing either 2-doses of an adenovirus vector (Ad5-YFV) or a heterologous strategy utilizing Ad5-YFV and a live-attenuated (LMA) vaccine were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
Mice immunized with a 2-dose strategy utilizing either 2-doses of an adenovirus vector (Ad5-YFV) or a heterologous strategy utilizing Ad5-YFV and a live-attenuated (LMA) vaccine were evaluated for protective efficacy against pneumonic plague. A single immunization event giving both Ad5-YFV and LMA …
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Elucidating the Immunogenicity and Protective Immune Response of a Trivalent Vaccine for Sudan Ebola, Marburg, and Lassa Fever Viruses
… the effect of a homologous versus a heterologous prime-boost immunisation schedule on the induction of both humoral and cellular immune responses. To do so, I first developed a highly sensitive, multiplex assay for the simultaneous detection of antigen-specific antibodies against several targets …
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INTERNALIZATION AND IMMUNOGENICITY OF MUCOSALLY-ADMINISTERED SOLUBLE AND PARTICULATE ANTIGENS
… an inferior immune memory, and understanding how prime-boost immunization regimens affect mucosal and systemic humoral immune memory remains an insufficiently explored area of research that is critical for vaccine development. In this work, we examined the routes of mucosal antigen internalization …
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An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines
… modified vaccinia Ankara (SAAVI MVA-C) or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on HIV-1 subtype C are able to successfully induce vaccine specific responses in Chacma baboons. The aim of the current study was to characterise the T cell memory phenotype distribution in …
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
… two-dose intramuscular (IM) regimen, or as an IM booster preceded by an oral priming immunization with commercial monovalent Rotarix®. Pigs were challenged with either P[6] or P[8] HRV to evaluate cross-protection of the nanoparticle vaccine. Both regimens were highly immunogenic, inducing high …
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Strategies to improve BCG-mediated protection from <i>Mycobacterium tuberculosis</i>
… lung. Recombinant viruses used in heterologous prime-boost immunisation regimens can evoke powerful T cell immune responses and are promising candidates for novel tuberculosis vaccines. In this thesis, the immunogenicity and protection protective efficacy of viral vectors expressing the …
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… Pfs25 epitopes within the viral capsid. These prime-boost vaccinations with Ad5-Pfs25 followed by capsid-displayed Pfs25 Ad vectors increase the Pfs25-specific antibody titer as compared to homologous prime-boost with Pfs25-alum. Ad-vectored prime-boosts also block transmission to the mosquito …
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Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
… a major challenge for conventional vector-based, prime-boost vaccinations. Thus, it is imperative that we explore nonconventional alternatives, such as boosting without vectors. We show here that repetitive intravenous boosting with peptide and adjuvant generates memory CD8 T cells of sufficient …
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Beak and feather disease virus candidate vaccine development
… the antigen in vitro and may prove useful in a prime-boost regimen together with one of the plant-produced vaccine candidates.
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Charakterisierung zellulärer Immunantworten von mit SIV immunisierten und infizierten Makaken
… Arbeit wurden in diesem Tiermodell drei Prime-Boost -Immunisierungsprotokolle, die hinsichtlich der Vektorkombinationen und Applikationsrouten variierten, auf ihre Immunogenität und Wirksamkeit gegenüber einer SIV-Infektion untersucht. Ein besonderer Schwerpunkt lag auf dem Vergleich der …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
… based on their different strengths to be used in prime-boost regimens to determine the immunogenicity of HIV-1C GagM in mice. The first was a pantothenic auxotroph of the tuberculosis vaccine Mycobacterium bovis Bacille Calmette Guérin (BCG). The second was a DNA vaccine vector with enhanced …
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Construction, characterization, and evaluation of CLH001 as a vaccine candidate against respiratory glanders
… immunized i.n. with 1.5x105 CFU of CLH001 in a prime/boost regimen showed full protection post-challenge with 1.5x104 CFU of B. mallei lux wt strain. Organs from surviving mice were clear of bacterial colonization and histopathological abnormalities. Immunized mice showed high B. mallei-specific …
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The development of novel HIV-1 vaccines using modified recombinant BCG
… vaccinia Ankara in the context of heterologous prime boost regimes. The tuberculosis vaccine Bacillus Calmette–Guérin (BCG) has a wellestablished safety profile as well as notable adjuvant activity with an estimated 3 billion doses administered globally since 1921. The development of modern …
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The State of T Cell Immunity against Influenza Virus in Humans and Exploration of Potential Strategies to Enhance Cell-Mediated Protection from Influenza Infection
… do not result in significant long-term boosting of pre-existing influenza-specific CD8 T cell responses and that a lifetime of acute influenza infections can result in a senescent phenotype similar to chronically stimulated dysfunctional cells. These data suggested that boosting …
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Phylogenetics and New Approaches to Vaccine Development for West Nile
… were engineered and administered to mice in a prime-boost approach. The vaccines were able to confer high degree of protection in mice against lethal challenge with highly virulent WNV LSU-AR01. Detailed immunological analyses of immunized mice revealed the production of neutralizing antibody …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… decreased avidity to antigen in an HIV-1 gp120 "prime-boost" vaccine model. Additionally, TFH cells from Bcl6FC mice produced higher levels of Interferon-γ, IL-10 and IL-21. Loss of TFR cells therefore leads to highly abnormal TFH and GC B cell responses. Overall, our studies have uncovered …
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… development and affinity maturation in a prime-boost vaccine scheme.
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Lipid-coated micro- and nanoparticles as a biomimetic vaccine delivery platform
… elicited measurable titers, and a prime-boost regimen of 2.5 ng ovaparticles adjuvanted with monophosphoryl lipid A elicited high titers that were sustained for >150 days. No studies to our knowledge have reported dose sparing to this degree with titers sustained over time. The …
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Improving efficacy of therapeutics by enhancing delivery using chemical engineering
… 7 times more antibodies compared to the current prime-boost profile using the same amount and type of vaccine. The antibodies generated were also of higher affinity. By improving antibody affinity and titer, this work may make existing vaccines for diseases such as HIV sufficiently efficacious to …
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