Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Primary somatosensory cortex"”.
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Role of mGluR5 and FMRP in mouse primary somatosensory cortex
… maybe exaggerated in FXS (Bear et al., 2004). Primary somatosensory cortex (S1) of rodents provides an excellent model system to study the role of MR genes in development because of its stereotypic, glutamate receptor-dependent, anatomical development (Barnett et al., 2006b; Erzurumlu and Kind, …
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fMRI for mapping the plastic somatotopy of primary somatosensory cortex - Development and clinical applications
… In this thesis, methods for fMRI mapping of the primary somatosensory cortex (S1) are optimised and subsequently applied in studies where a plastic reorganisation of S1 is hypothesised. Initially, the impact of spatial resolution and smoothing on fMRI data of detailed S1 activation was …
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A Rodent Animal Model for Forelimb to Lower Jaw Reorganization in Primary Somatosensory Cortex (SI) Barrel Field
… underlying cortical reorganization in rat primary somatosensory (SI) cortex that follows forelimb deafferentation. The majority of human patients suffering from limb loss or brachial plexus avulsion injury, as well as patients that receive brachial plexus anesthesia, report phantom limb …
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Exploring lateralized sensorimotor processing using somatosensory evoked potentials
… data to support their findings. By utilizing somatosensory evoked potentials (SEPs) we can gain insight into the underlying neurological processes at the levels of the spinal cord and the cortex in response to movement and motor learning. The research conducted showed greater accuracy in the …
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Examination of neocortical plasticity during forebrain-dependent trace-associative learning tasks
… because it requires an intact neocortex and hippocampus (Solomon et al., 1986; Moyer et al., 1990; Kim et al., 1995; Weiss et al., 1999a; Takehara et al., 2002; Galvez et al., 2007). Using the trace-eyeblink conditioning paradigm with whisker stimulation as the CS …
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A tailored biocompatible neural interface for long term monitoring in neural networks
… activity were obtained in both cerebellum and cortex cerebri (papers I-III). In paper IV, we evaluated the importance of mechanical flexibility and demonstrated that probe flexibility has a significant impact on the astroglial scar, but not on the loss of neurons nearby. Moreover, by embedding …
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The role of fast-spiking interneurons in cortical map plasticity
Rodents have a topographic map in primary somatosensory cortex of the contralateral facial whiskers. A brief period of whisker trimming causes the representation of the nontrimmed whiskers (spared) to expand into the cortex that has lost its principal sensory input (deprived). It has been …
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BRAIN MECHANISMS SUPPORTING EXPECTATION AND TOP-DOWN ATTENTION TO PAINFUL STIMULI
… lobule/precuneus, dorsolateral prefrontal cortex (DLPFC) and cerebellum were implicated in these processes. In addition, attention to spatial and intensity features of pain activated intraparietal sulcus and frontal eye fields. These areas likely activated brain areas that were relevant to …
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Mesoscale activated states gate spiking in the awake brain
… as well as in a model neocortical region, the primary somatosensory cortex. We discovered that the majority of spikes are in fact preceded not only by a fast, monotonic rise in voltage over a few milliseconds, consistent with fast input integration within a neuron, but also by a prolonged, …
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The role of IL-17a in the rescue of ASD-like behavioral phenotypes following immune stimulation in a mouse model of neurodevelopmental disorders
… correlated with reduced hyperactivation in the primary somatosensory cortex dysgranular zone (S1DZ), a region that has been previously shown to be tightly linked to MIA behavioral phenotypes. Consistent with the selective effects of LPS within MIA offspring, this reduction in hyperactivation was …
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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… neuropeptide Y (NPY) increased in the insular cortex (IC) within the peri-infarct zone. NPY also increased ipsilaterally in the basolateral nucleus of the amygdala, whereas leucine-enkephalin, dynorphin and neurotensin increased ipsilaterally in the central nucleus of the amygdala. Sham MCAO …
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Impact of Noise and Spike Initiation Properties on the Encoding and Transmission of Neural Information
… I found that layer 2/3 pyramidal neurons in primary somatosensory cortex spike intermittently to inputs repeated at frequencies perceived as vibration. The fraction of inputs evoking a spike varies with input amplitude, enabling firing rate to encode stimulus intensity. Despite being small in …
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Sensorimotor Recovery, Functional and Structural Brain Plasticity, and the Development of Chronic Pain Following Upper Limb Peripheral Nerve Transection and Microsurgical Repair
… results in reduced BOLD activation within the primary and secondary somatosensory cortices. Interestingly, the regions of reduced BOLD corresponded with gray matter thinning which was negatively correlated with behavioural measures of sensory recovery. Structural abnormalities were also …
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Face Motor Cortex Neuroplasticity Associated with Alterations in the Oral Environment of the Adult Rat
… changes in motor representations within the primary motor cortex (M1) have been described after peripheral manipulations and implicated in motor learning and adaptation processes. It is unclear whether dental manipulations, which may result in altered oral sensorimotor functions, are …
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Acute Physiological Effects of Brain-Generated 17β-Estradiol in the Rodent Primary Auditory Cortex
… large population of neurons in medial prefrontal cortex (mPFC), primary somatosensory cortex (S1), primary auditory cortex (A1), and primary visual cortex (V1). Next, in vivo field recordings were used to determine the effects of acute, bidirectional E2 manipulations on short- and long-term …
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Unsupervised tracking and automated analysis of multi-population neural activity under anesthesia
… and inhibitory populations in layer 2/3 of the primary somatosensory cortex. Although neuronal activity decreases at deeper levels of anesthesia, excitation and inhibition remain balanced when anesthetic concentrations are equilibrated. In contrast, the network reliably goes out of balance for …
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Identifying the Neural Correlates of Swallowing in Two Age Groups Using fMRI
… statistically stronger activations mainly in the primary somatosensory cortex of young adults during most tasks examined (p<0.05). Within and between group comparisons of hemispheric preference failed to find groupwise significant lateralization of the entire sensorimotor cortex or a significant …
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Cognition in healthy aging and Parkinson's disease : structural and functional integrity of neural circuits
… 4 investigates healthy age-related changes in somatosensory mu rhythms and evoked responses and uses a computational model of primary somatosensory cortex to predict the underlying cellular and neurophysiolgical bases of these alterations. In contrast to the widespread cortical changes seen in …
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3-D optical waveguide arrays for in-vivo optogenetics : development and application
… patterned light is delivered to targets in the primary somatosensory cortex while electrical activity is recorded from the primary motor cortex.
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Neuronal Correlates of Reward Contingency in the Rat Thalamocortical System
… Stimulus discrimination requires activation of primary sensory areas in the brain, but expectation is traditionally associated with the activation of higher-order brain areas. Sensory information obtained by tactile organs is represented along the primary areas that comprise the trigeminal …
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