Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Primary sensory neurons"”.
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
Neurotrophins regulate sensory neuron survival, differentiation and phenotype, yet much remains to be discovered. The role of neurotrophins and neurotrophin receptors in adult primary sensory neurons was investigated along three main avenues 'in vivo'. First, to better predict neurotrophin …
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Distribution and function of TRP ion channels in primary sensory neurons
… CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. The CB1 receptor agonists anandamide and HU210 also fail to inhibit …
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
… the possible neurochemical changes occurring in primary sensory neurons, the effects of a single-dose intravenous administration and a well-established “chronic” schedule (three times/week for 8 weeks) in a rat model of bortezomib-induced peripheral neuropathy have been examined. The …
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Neurochemical characterization of the rodent primary sensory system
Primary sensory neurons and their associated tissues are important targets for neurochemical study. Disorders of the sensory system, including chronic pain and itch, can be extremely devastating and, in many cases, difficult to treat. Part of the difficulty of treating such disorders is the limited …
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Mechanisms of Volatile Odorant Detection and Corresponding Behavioral Effects in Drosophila
… to environmental stimuli, which are mediated by primary sensory neurons of different modalities including sight, hearing, touch, taste, and smell. Olfaction serves a major role in conveying important information concerning a variety of behavioral determinants such as food sources, danger, and …
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The morphology, neurochemistry, and consequences of sympathosensory plexuses
The development, maintenance, and survival of neurons depend on the function of neurotrophins such as nerve growth factor (NGF). One population of neurons that rely heavily on NGF for axonal growth and survival is the postganglionic sympathetic neurons. Trauma or disease resulting in injury to the …
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MRGX1-TRPAI in inflammatory pain signalling
… at the peripheral terminals of specialised primary sensory neurons known as nociceptors. Nociceptors detect noxious (painful) stimuli to evoke pain sensation via the activation of Transient Receptor Potential Ankyrin 1 (TRPA1). TRPA1 activity can be modulated by G-Protein Coupled Receptors …
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Transcriptional control of somatosensory neuron diversification in Drosophila
Primary sensory neurons deliver information from the periphery to specific circuits in the central nervous system. It is vital that each sensory neuron detects the appropriate type of stimulus and conveys that information to appropriate regions of the sensory neuropil to target second-order …
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Sustained Release of Growth Factors from Hyaluronic Acid Hydrogels and Polyethylene-Glycol Microparticles for Axonal Growth
… the media was correlated to the axonal growth of primary sensory neurons, as well as that of stem cell-derived motoneurons and interneurons to more closely match the type of cells that are present in the spinal cord. A synergistic effect on neurite outgrowth was found for the combination of NT-3 …
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Functional Regulation of Ion Channels in Dorsal Root Ganglion Neurons by Magi-1: Implications in Pain Signaling
… to alterations in ion channel expression in neurons along the pain-axis. Ion channels provide neurons with a mechanism to detect and respond to changes in their environment. Adaptive changes in ion channel expression are major driving factors for the increased neuronal excitability seen in …