Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"Primary nucleation"”.
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The influence of primary nucleation and rime splintering on ice number concentrations in southern ocean cumuli
… simulations of a cumulus cloud undergoing primary ice nucleation with the observed numbers of ice-nucleating aerosol particles fail to reproduce the observed high ice number concentrations. Only through the mechanism of multiple, successive thermals in the simulations, combined with the …
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Primary and secondary crystal nucleation of pharmaceutics
… pharmaceutical and chemical industries. Crystal Nucleation defines the crystal size distribution of the obtained crystal population affecting downstream operations. The literature agrees on crystal nucleation division as primary and secondary nucleation depending on the conditions of the used …
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Crystallization and Melting Studies of Poly(ε-caprolactone) and Poly(ethylene oxide) using Flash™ Differential Scanning Calorimetry and Preparation and Characterization of Poly(δ-valerolactone) Fractions
… A transition from homogeneous to heterogeneous primary nucleation was observed at −5°C. The kinetic analysis suggested that the crystal growth geometry depends strongly on temperature, where rod-like structures begin to appear near the glass transition temperature, highly branched solid sheaves …
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Effects of system complexity on protein aggregation in neurodegeneration
… by cholesterol via a mechanism of heterogeneous primary nucleation. Finally, I will show the effect that mixtures of lipids of increasing complexity have on rAβ42 and introduce the concept of resilience in complexity—where complex lipid mixtures show an overall neutral kinetic contribution to …
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Containerless processing of stainless steel
… the study of phase selection and secondary nucleation mechanisms for that alloy as well as measurements of delay times and growth velocities. Double recalescence events were observed for the first time at temperatures near the To temperature of the metastable ferritic phase, defining a value …
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Protein-lipid interactions in molecular pathways of Parkinson’s and Alzheimer’s diseases
… results show that lipid surfaces trigger Aβ42 primary nucleation by promoting liquid-liquid phase separation, which is an intermediate state in the amyloid cascade. These fundamental findings enhance the understanding of lipid-mediated molecular pathways in AD and PD, and provide insights that …
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Chemical Mutagenesis for the Modulation and Study of Protein Function and Dysfunction within Alzheimer’s Disease
… that potently enhances the inhibition of Ab’s primary nucleation. The second application focuses on the other major protein implicated in the pathology of AD: Tau. In AD, tau aggregates into ordered amyloid fibrils and contains a plethora of post-translational modifications (PTMs), many of …
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B phase nucleation and A-B interface dynamics in superfluid 3He
This thesis deals with the theory of the primary nucleation and subsequent expansion of the superfluid 3He-B phase in the metastable, hypercooled A phase. An overview of the theory of dynamical phenomena in Fermi superfluids is presented in Chapter 1 with an eye towards formulating a theory …
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B phase nucleation and A-B interface dynamics in superfluid helium-3
This thesis deals with the theory of the primary nucleation and subsequent expansion of the superfluid $\sp3$He-B phase in the metastable, hypercooled A phase. An overview of the theory of dynamical phenomena in Fermi superfluids is presented in Chapter 1 with an eye towards formulating a theory …
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Investigating the Phase Behaviour of the Alzheimer’s Amyloid-β Peptide
… proteins into amyloid fibrils takes place via a nucleation pathway leading from the reactants (monomers) to the products (amyloid fibrils) through a series of intermediates (oligomers). Recently, an alternative aggregation pathway, named the condensation pathway has emerged, where proteins may …
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Growth and Toxicity of Amyloid β Polymorphs
… suggested that bexarotene interferes with the primary nucleation step. Cryo-electron microscopy revealed that bexarotene enforces a distinct molecular structure (polymorph) for fibrils. For molecular-level insight, we employed atomic force microscopy (AFM) to monitor the growth of individual …
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Acoustic emission from the crystallization of potassium bromide doped with lead
… the hypothesis of inter-crystal interaction. Primary nucleation could not be detected acoustically. The end of crystal growth was acoustically determinable. The AE associated with the growth of the dendritic form of KBr finished abruptly when the maximum image whiteness was reached. The …
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Controlled self-assembly of natural proteins into hierarchically structured functional materials
… molecules accelerates self-assembly by promoting primary nucleation. The results provided useful insights into nature’s strategies for controlling the assembly of proteins into materials. The second part describes the fabrication of silk-inspired protein-based microfibres using nanofibrils …
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Phase transitions of poly (l-lactic acid) in bulk and in solution
… scattering (WAXS and SAXS) are adopted as the primary experimental techniques. Crystallization during annealing and drawing in melt-spun PLLA fibers is studied by WAXS with a quantitative evaluation of crystallinity and orientation. This represents the study of phase transitions of PLLA in bulk …
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Chiral resolution control in batch and continuous crystallization processes for a conglomerate forming compound
… remains in solution. Given enough time, however, nucleation of the unwanted enantiomer in the supersaturated solution is inevitable in any preferential crystallization process, batch or continuous.The work outlined in this thesis focuses on the control in both batch and continuous preferential …
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On the aberrant nature of tau protein: biophysical approaches to characterise and target aggregation in neurodegeneration
… as fragmentation and surface-catalysed secondary nucleation, as key contributors to the formation of toxic misfolded oligomers of tau. This finding serves as the basis for our drug discovery platform. Finally, building on this kinetic framework, we developed a drug screening assay to identify …
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Manipulation and Characterization of Morphology and Composition in Mono- and Heterometallic Nanoparticles
… shell thickness control whilst avoiding the primary-nucleation of Fe3O4 impurities was achieved. The coating of non-magnetic Pt cores established that a magnetic seed was not necessary for shell growth. A synthetic strategy was then developed to coat Cu0 plasmonic NPs with an Fe3O4 shell. …
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Crystal growth and nucleation kinetics of diethylenetriammonium hexachlororhodate (III) salt
… The objective of this work is to determine nucleation and growth kinetics of diethylenetriammonium hexachlororhodate (III) salt. Two reactor configurations, namely a transient continuous stirred tank reactor (CSTR) and a t-mixer plug flow reactor (PFR), were used to determine nucleation and …
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Building a bridge between biophysics and neurobiology: A synergic approach to develop Alzheimer’s disease translational models and research tools
… Aβ aggregate species that may not be one of the primary AD cytotoxic agents. The Aβ aggregation cascade involves a series of complex processes, wherein misfolded monomers transition through a wide range of intermediate oligomeric states to form assemblies such as protofibrils and mature fibrils, …