Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Primary neuronal cells"”.
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… aims to investigate the bioactivities of SFN on neuronal cells. PC-12 and SH-SY5Y cells were used to resemble neuronal-like systems to research especially autophagy as well as nuclear factor E2-related factor 2 (Nrf2) and how these pathways might influence neuroprotective abilities of SFN. Basal …
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Direct-write assembly of 3D microperiodic scaffolds for tissue engineering applications
… of polylysine. They are then cultured with primary neuronal cells, which form intricately branched networks. Confocal laser scanning microscopy reveals that both cell distribution and extent of neuronal process alignment depend upon scaffold architecture. Silk fibroin inks are prepared by …
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GPR50, a potential factor involved in psychiatric disorders interacts with Alzheimer’s disease-related protein β- secretase (BACE1)
… increased endogenous BACE1 activity in HEK293 cells, so I hypothesised that there is a functional interaction between the two. In this thesis, I investigated the relationship between GPR50 and BACE1 by identifying the effects of GPR50 on BACE1 expression and function, which may provide an …
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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the expression and functional roles in neurodegenerative diseases
… in MND cellular models such as NCS-34 cells using tunicamycin treatment. Altering the expression of TSG101 and CHMP2B demonstrated changes in TDP-43 and mTOR expression including altered autophagy markers such as LC3B and p62. Finally, knockout of SOCS3 enhances autophagy via TBK1 …