Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Primary melanoma"”.
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Genetic alterations defining human primary melanoma and mechanisms of immune evasion
The somatic mutations found in melanomas reflect the biological processes that govern tumour development. They also help shape how tumours evolve and escape immune regulation. Studying these changes can therefore help to refine our understanding of melanoma progression with the added potential to …
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The molecular landscape of cutaneous melanoma and its clinical implications
Cutaneous melanoma arises due to the uncontrolled proliferation of melanocytes. It is the deadliest form of skin cancer and its incidence, particularly in younger adults, is rapidly rising worldwide. Over the past decade, multiple large-scale sequencing studies have uncovered the molecular …
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Prognostic biomarker discovery from omics data using machine learning approaches
… different diseases: Alzheimer’s disease (AD), primary melanoma and coronavirus disease 2019 (COVID-19). In my second chapter, I contributed to the discovery of a new metabolic signature, to predict which patients with mild-cognitive impairment would later develop AD. As there were thousands of …
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Quantitative analysis of neuropilin-2 expression in pigmented lesions and melanoma
… the American population over the last 3 decades. Melanoma, the most serious and dangerous form, causes the most skin cancer related deaths. If melanoma is found early enough, it can be treated and cured. Current therapy for melanoma is based on the stage of the disease. It is crucial to identify …
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Untersuchung der Genexpression von ABC- und SLC-Transmembranproteinen mit Beteiligung am aktiven Transport von Antigenen, Eikosanoiden und Zytostatika beim malignen Melanom
Malignant melanoma is the most aggressive form of human skin cancer. Rising incidence in the Caucasian population and disappointing results of chemotherapy at metastatic stage make melanoma a major medical challenge. The last decades have shown great progress in discovery and description of …
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An Integrated Bioinformatics Approach for the Identification of Melanoma-Associated Biomarker Genes. A Ranking and Stratification Approach as a New Meta-Analysis Methodology for the Detection of Robust Gene Biomarker Signatures of Cancers.
… However, meta-analyses of published arrays using melanoma as a test cancer has uncovered significant inconsistences that hinder advances in clinical practice. In this study a computational model for the integrated analysis of microarray datasets is proposed in order to provide a robust ranking of …
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Epigenetic dysregulation of novel candidate genes in melanoma
Cutaneous melanoma (CM) is an aggressive neoplastic disorder of melanocytes accounting for 4% of skin cancers, but over 75% of skin cancer-related deaths. The outlook for advanced melanoma is typically poor, particularly for patients with distant and/or visceral metastatic disease. Although new …
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Tumour chemo sensitivity assays: an investigation into the susceptibility of cells to chemotherapeutics
… effect of commonly used cytotoxicity drugs on melanoma cells. It was hoped to find both a sensitive and resistant cell line for further analysis by MALDI-MS. The study revealed how cells of the same histological and tissue type can respond differently to the same anticancer drug with one cell …
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Circulating tumour DNA: A non-invasive biomarker for melanoma
Cutaneous melanoma accounts for 90% of all skin cancer deaths (Balch et al., 2010) and is responsible for 3.6% of deaths from cancer in Australia (Australian Institute of Health and Welfare, 2016). Whilst early detection and successful surgical removal of primary melanomas have improved survival …
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Investigation into the potential of methylene blue and its derivatives to be used in the photodynamic therapy of non-pigmented and pigmented cells
… proved of no use in the treatment of malignant melanoma due, possibly, to competition between the photosensitizer and melanin for light absorption. Second-generation photosensitizers have tended to be porphyrin-based molecules, many of which have reached various stages of clinical trial. Of non …
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The detection of occult metastatic disease in patients with cutaneous melanoma
The ability to identify melanoma patients with progressive disease is central to efficient management. The challenge therefore, is to develop prognostic markers and techniques which will allow the identification of those patients whom, at the time of primary tumor diagnosis, already have …