Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Primary brain tumors"”.
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Characteristics of Individuals Undergoing Panel Genetic Testing For Primary Brain Tumors
… genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution. Our aim was to describe patient-specific characteristics and family histories …
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NEW ADVANCES IN QUANTITATIVE RADIOLOGY: RADIOMICS IN NEURORADIOLOGY APPLIED TO PRIMARY BRAIN TUMORS USING A MACHINE LEARNING APPROACH
… extracted from multiple tumor subregions on MR brain images to predict MGMT promoter (MGMT) methylation status and isocitrate dehydrogenase (IDH) mutation in glioma patients through a multiparametric MRI-based radiomics model, using arterial-spin labelling (ASL) perfusion imaging. Methods: …
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Utilizing the Immunomodulatory Effects of Electroporation for Treating Brain Tumors
Brain tumors are among the most devastating types of solid tumors to treat. Standard of care for glioblastoma (GBMs), the most aggressive form of primary brain tumors, has failed to improve the current survival rates in the past decades. Despite many other solid tumors, recent advances in cancer …
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Potential Rest Targets In Neural Stem Cells and Glioblastoma-Derived Stem Cells
<p>Glioblastoma multiforme (GBM) tumors are the most common malignant primary brain tumors in adults. The current theory is that these tumors are caused by self-renewing glioblastoma-derived stem cells (GSCs). At the current time, the mechanisms that regulate self-renewal and other oncogenic …
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Adapting a gelatin hydrogel platform to investigate glioblastoma progression
… there are approximately 80,000 new cases of primary brain tumors diagnosed annually, with a third of those being malignant brain cancer. Glioblastoma is the most common and lethal form of adult brain cancer, contribute to about 13,000 new cases annually in the U.S. Despite current clinical …
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Maximizing Local Access to Therapeutic Deliveries in Glioblastoma: Evaluating the utility and mechanisms of potential adverse events for minimally invasive diagnostic two novel therapeutic techniques for brain tumors
… Dogs and humans are the only species in which brain tumors commonly develop spontaneously, with an estimated post-mortem frequency of primary brain tumors approximating 2% in both species. Gliomas represent about 35% of all canine primary brain tumors, with high-grade oligodendroglioma and …
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Roles of the P2X7 receptor in C6 astroglioma: in vitro and in vivo studies
… system (CNS). Gliomas are the most common primary brain tumors with presently no cures. The roles of the P2X7R in these diseases have not been previously studied and in this work, I have used the rat C6 glioma as an experimental model system to investigate expression and function of the …
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Overcoming therapeutic resistance in glioblastoma using novel electroporation-based therapies
… the most common and deadliest of the malignant primary brain tumors in humans, with a reported 5-year survival rate of only 6.8% despite years of extensive research. Failure to improve local tumor control rates and overall patient outcome is attributed to GBM's inherent therapeutic resistance. …
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A proteomics study to investigate the role of the neural niche in the development of metastatic HER2+ breast cancer
Advanced stage tumors can acquire the ability to divide uncontrollably, invade the surrounding matrix, and circulate through the bloodstream or lymphatic system to distant organs in a process known as metastasis. The brain, which is shielded from the environment by the blood brain barrier, offers …
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MECHANOPROPERTIES, HETEROGENEITY AND CELL MIGRATION IN GLIOBLASTOMA
Glioblastomas (GBMs) are primary brain tumors endowed with inter- and intra-patient heterogeneity and extreme di↵usivity. As heterogeneity is studied with genomic and transcriptomic analysis, little is known on how it is reflected on cell migration, mechanoproperties and motility modes. Generally, …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… (GBM), one of the most malignant forms of primary brain tumors, is characterized by its highly heterogenous genetic composition, aggressive infiltration of surrounding tissue, and resistance to current treatments. Gene expression analysis has characterized GBM into four main types, with a …
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Development and Evaluation of Brain Tumor Targeted Liposome Delivery System for Paclitaxel
<p>Primary brain tumors are a relatively common cause of cancer-related deaths. High-grade gliomas are the most common type of primary brain cancer, and the affected patients have a median survival of less than 1 year. Almost all malignant gliomas are incurable with the present standards of …