Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Primaquine"”.
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Covalent Binding and other Mechanisms of Primaquine Toxicity
<p>A dose-dependent covalent binding of primaquine to mouse liver microsomal protein was found in both in vitro and in vivo studies. The binding in vitro was linear during the first 90 minutes of incubation and dependent on the concentration of mouse liver microsomal protein. The in vitro covalent …
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Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes
The 8-aminoquinoline (8AQ) antimalarial drug primaquine (PQ) is the only drug for prevention of malaria relapse. Moreover, PQ also has gametocytocidal activity against Plasmodium falciparum. However, clinical use of PQ has been limited due to its hemolytic toxicity, especially in …
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Role of Cytochrome P-450 in Methemoglobin Formation by Primaquine with Hamster Liver Microsomes
… in <em>in vitro</em> methemoglobin formation by primaquine was investigated through a series of experiments with golden-Syrian hamsters, treated before sacrificing with phenobarbital or 20-methylcholanthrene to increase the cytochrome P-450 content or with cobaltous chloride to cause its …
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Inhibition of the endosomal recycling pathway to overcome resistance to cancer therapies
… found that the endosomal recycling inhibitor primaquine downregulates ER-α and AR expression. We used Western blot, quantitative RT-PCR, and immunofluorescence microscopy to confirm the RPPA results. We found that another endosomal recycling inhibitor, monensin, also potently downregulates …
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Antitumor activity of antimalarials in human breast cancer cells
… apoptosis. MTS IC50 of amodiaquin, chloroquine, primaquine, quinidine as well as quinine induced hyperacetylation of histone H4 without inhibiting HDAC activity. These results indicate that an alkylamino-substituted quinoline ring might be important for acetylation of histone H4. Accumulation of …
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Development of novel strategies to combat multidrug resistance mediated by efflux transporters and intracellular bacteria
… hydroxychloroquine, quinine, mefloquine and primaquine in an effort to inhibit PfCRT. A quinine dimer, Q2, blocked PfCRT mediated efflux and successfully cleared parasitemia <em>in vivo</em> in a <em>Plasmodium berghei</em>mice model.Efforts to target pathogenic bacteria that evade …
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Estudo de modelagem molecular de derivados de desoxiuridina como inibidores da dUTPase de Plasmodium falciparum.
… treatments include the drugs ch loroquine, primaquine, artemisinin and lumefantrine. However, due to its indiscriminat e use for years, parasite resistance to these treatments has become a big pro blem. The enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) of Plasm odium …
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Anti-Nucleic Acid Antibody-Mediated Cross Presentation of An Antigen and Its CD8+ T Cell Activation
… and cycloheximide-sensitive, chloroquine- and primaquine-insensitive pathway, resulting in loading of the CTL epitope onto H-2Kb. In vivo cross-presentation and cross-priming was efficient, even without adjuvant; injection of mice with 3D8 scFv-OVA250-264 induced cross-presentation of the CTL …
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The Economics of Vivax Malaria Treatment
… and a potentially cost-saving alternative where primaquine is prescribed without screening. The costs of implementing G6PD screening were collected in three countries, and highlighted that RDTs consistently reduced costs as compared to the widely-used fluorescent spot test. <br></br><br></br> …
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Impact of endosomal recycling inhibitors on drug resistant and immune tolerant breast cancers
Breast cancer (BC) is the most common and frequent of all the cancers, accounting for about 25% of all the cases of cancer detected in women annually. There are a number of approved drugs on the market that have been developed or repurposed for the treatment of BC. However, a recurrent problem …