Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Pri-miRNA"”.
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Sequence determinants of pri-miRNA processing
MicroRNAs (miRNAs) are short RNAs that regulate many processes in physiology and pathology by guiding the repression of target messenger RNAs. For classification purposes, miRNAs are defined as ~22 nt RNAs that are produced by the cleavage of endogenously transcribed hairpins. From a cellular …
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HP1BP3, A Chromatin Retention Factor for Co-Transcriptional MicroRNA Processing
… expression post-transcriptionally. MicroRNAs (miRNAs) are a family of ~21-nt cellular RNAs that govern numerous pathological and physiological processes by mediating translational repression and deadenylation/decay of cognate mRNA. Dysregulation of miRNA expression have been associated with …
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Understanding Recognition of Primary MicroRNAs by Human Drosha/DGCR8
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by suppressing messenger RNAs. The RNase Drosha, as part of the Microprocessor complex, performs the initial processing step in miRNA biogenesis. Drosha, in complex with its partner protein DGCR8, must distinguish its RNA …
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Development and Evaluation of Nano‑scale Systems for Targeted Delivery to Treat Liver Fibrosis
… line. Later, GFAP promoter driven HSC‑specific pri‑miRNA mimic and pri‑miRNA cluster mimic showed HSC‑specific TGF‑β1 gene silencing to avoid nonspecific inhibition of TGF‑β1 expression in other cells and organs.</p> <p>The novel LPA antagonist, PTP, can interact with LPA receptor on the surface …
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Expression analysis of Drosophila melanogaster microRNAs
miRNAs sind endogen exprimierte winzige regulatorische RNAs mit einer Länge von 20-25 Nukleotiden. Bereits einige hundert pflanzliche und tierische miRNA Gene sind identifiziert worden. Zusammen bilden sie eine große Familie regulatorischer Moleküle, die wichtige zelluläre und …
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Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System
MicroRNAs (miRNAs) are short, non-coding RNA sequences that are generated from longer primary transcripts (pri-miRNA). These pri-miRNAs are processed by the endonuclease Drosha into a hairpin secondary structure (pre-miRNA), exported from the nucleus and cleaved by the enzyme Dicer to form a duplex …
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Targeting oncogenic microRNAs in malignant germ cell tumours.
… are a heterogenous group of tumours that occur primarily in the testes and ovaries but also in other anatomical sites, and affect people of all ages. It was established by the Coleman group through microRNA profiling in 2010 that all mGCTs, regardless of tumour site, patient age or histological …
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The Regulation of Microrna Biogenesis By Ribosome-Interacting Proteins
<p>MicroRNA (miRNA) are small, non-coding RNAs that affect gene expression through degradation of complementary mRNA targets or inhibition of translation. As they affect approximately 50% of all cellular processes, miRNA are tightly regulated by the cell through transcriptional and …
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SR proteins in microRNA/mRNA biogenesis
… mechanism may be involved. In order to test if miRNAs are also involved in such negative feedbacks, small RNA sequencing was used to identify differentially expressed miRNAs after SF2/ASF overexpression in an inducible stable cell line system. Among the 40 differentially expressed miRNAs, miR-7 …
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The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation
… the host. NK cells protect the host via two primary effector pathways - direct cytotoxicity, and indirect cytokine/chemokine production (e.g. IFN-g), which shapes the subsequent adaptive immune response. The importance of this role of NK cells in human health is highlighted by the recurrence …