Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Presynaptic function"”.
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Presynaptic signalling in Huntington’s disease
… in many neurodegenerative disorders, synaptic dysfunction is a critical early event in the progression of HD. It is known that both protein and mRNA expression of brain derived neurotrophic factor (BDNF) are defective in HD patients and preclinical models. Crucially, members of BDNF signalling …
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Regulation of Excitatory Neurotransmission, Synaptic Plasticity, and Learning by Cyclin-Dependent Kinase 5
… synaptic plasticity. In addition to regulating functional plasticity, Cyclin-dependent kinase 5 also plays roles in structural plasticity and presynaptic function. Cyclin-dependent kinase 5 facilitated the calpain-mediated degradation of spectrin in vitro. Spectrin degradation and depolymerized …
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Dissecting Synaptic Vesicle Endocytosis
… knockouts indicated that there is redundant presynaptic function of the proteins. Loss of either protein alone results in a subtle phenotype; only in the double knockout is synaptic vesicle endocytosis strongly impaired. However, even lacking both dynamin 1 and dynamin 3 synaptic vesicles can …
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Cytoskeletal Networks Driving Presynaptic Plasticity
… the field of synaptic plasticity by focusing on presynaptic terminals, which are equal partners with their postsynaptic counterparts. To date, the study of presynaptic plasticity has been difficult due to the limited number of presynaptic signaling molecules currently identified (particularly …