Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Pressure-overload-induced heart failure"”.
-
Study and Therapeutic Interference of T Cell Function in Pressure Overload-induced Heart Failure
Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. We attempted to identify and exploit better targets in cardiac …
-
PERM1-Mediated Metabolic Crosstalk Between the Heart and Skeletal Muscle in Pressure Overload-Induced Heart Failure
Heart failure is a complex syndrome with high mortality, as nearly 50% of patients die within five years of diagnosis. Among its systemic complications, cardiac cachexia–a condition characterized by severe unintentional weight loss due to cardiac dysfunction– serves as an independent predictor of …
-
PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
Mechanical pressure overload is a central driver of pathological cardiac hypertrophy and fibrosis, yet the mechanism linking mechanical cues to adverse remodelling remains unclear. Fibroblasts are major effector cells of fibrotic remodelling. Still, the precise mechanism by which fibroblasts decode …
-
Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
Objective: Heart failure with preserved ejection fraction (HFpEF) is a disease associated with significant clinical pathophysiological heterogeneity in which maladaptive cardiac fibrosis, in both the right and left ventricles of the heart, plays a unique role in the manifestation of disease. …