Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Pressure Overload"”.
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… the exact mechanistic pathway associated with pressure overload-induced cardiac remodeling remains to be elucidated. In order to address this issue, we designed this study to determine pathways associated with pressure overload induced cardiac remodeling and identify therapeutic targets to …
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Cardiac hypertrophy and the dynamic changes in structure and function after pressure overload
… of pathological hypertrophy following pressure overload. This suggests strongly the involvement of p38γ or δ MAPK in the development of cardiac remodelling. Conclusion: Pharmacological inhibition of p38γ or δ MAPK may pose a potential new treatment avenue in the prevention of …
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Study and Therapeutic Interference of T Cell Function in Pressure Overload-induced Heart Failure
Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to redundant functions of individual cytokines. We attempted to identify and exploit better targets in cardiac …
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PERM1-Mediated Metabolic Crosstalk Between the Heart and Skeletal Muscle in Pressure Overload-Induced Heart Failure
Heart failure is a complex syndrome with high mortality, as nearly 50% of patients die within five years of diagnosis. Among its systemic complications, cardiac cachexia–a condition characterized by severe unintentional weight loss due to cardiac dysfunction– serves as an independent predictor of …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
Mechanical pressure overload is a central driver of pathological cardiac hypertrophy and fibrosis, yet the mechanism linking mechanical cues to adverse remodelling remains unclear. Fibroblasts are major effector cells of fibrotic remodelling. Still, the precise mechanism by which fibroblasts decode …
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The Angiotensin Receptor (AT₁) Inhibitor, Losartan, Slows Post-Natal Thickening of the Left Ventricle
… regulates growth of heart tissue in response to pressure-overload. Upon parturition, the mammalian left ventricle (LV) experiences pressure overload to which it responds by rapid growth, becoming thicker than the right ventricle (RV) in a few days. We assessed a role for a cardiac RAS in left …
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Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
… and regulation in a mini-swine model of pressure overload-induced heart failure (HF). To gain insight about the regulation of fibrosis in this model, biological inputs were measured in both the right and left ventricles and used as input variables in an artificial neural network model …
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Cardiomyocyte Autophagy Is Induced by Protein Aggregation in Heart Disease
… and protein aggregation in the acute period of pressure overload. Given the simultaneous presence of autophagosomes and aggregates, and autophagy's role in bulk degradation, I postulated these events were mechanistically linked. I designed experiments to test the hypotheses that protein …
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Role of the Endocannabinoid System in Cardiac Remodeling
… CB2 receptors in cardiac remodeling secondary to pressure overload (PO) induced hypertension at 3, 5, 14 and 28 days. The expression of the cannabinoid CB1 and CB2 receptors on human ventricular fibroblasts and the effects of their direct modulation on the fibrotic responses were also …
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Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension
… (PAH), where RV failure in the setting of pressure overload is the leading cause of death. PAH will be introduced in the 2nd chapter of this thesis by comparing and refining contemporary mortality risk assessment strategies. I will then explore 1) RV neurohormonal function and, 2) RV …
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Dynamic Remodeling of The Stressed Heart: Role of Protein Degradation Pathways
… a variety of environmental stresses, including pressure overload, volume overload, mechanical or pharmacological unloading and hormonal or metabolic disturbances. All these responses are linked to the inherent capacity of the heart to rebuild itself. Particularly, cardiac pressure overload …
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Cardiac PI3Kα Signaling and K+ Channel Regulation in Cardiac Hypertrophy and Heart Failure
… current densities are decreased in pressure overload-induced left ventricular hypertrophy, resulting in action potential and QT prolongation. Cardiac hypertrophy also occurs with exercise training, but this "physiological hypertrophy" is not associated with electrical abnormalities …
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Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling
… in myocardial fuel utilization, I induced pressure overload injury through transverse aortic constriction (TAC) on SCOT-Heart-KO mice and observed adverse ventricular remodeling, including markedly increased left ventricular volume and diminished ejection fraction relative to control mice. …
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Multivariate analysis of transcriptional changes following restoration of SERCA2a levels in failing rat hearts
… gene transfer of SERCA2a in a rat model of pressure overload hypertrophy in transition to heart failure. We combined model- and data-driven approaches to analyze the resulting multivariate microarray expression dataset corresponding to 4237 transcript sequences in six experimental groups. A …
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Physiological Role of the α<sub>2</sub>-Isoform of the Na, K-ATPase in the Regulation of Cardiovascular Function
… role in the regulation of systolic blood pressure (SBP). However, the organ system/cell type expressing α<sub>2</sub> that is required for this regulation has not been fully defined. The present dissertation study uses tissue-specific knockouts of α<sub>2</sub> to further define the …
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
… induced cardiac hypertrophy by slow progressive pressure overload in adult cats. Isolated adult feline ventricular myocytes (AFMs) exhibited increased STIM1 expression and activity, which correlated with altered Ca2+ handling. Use of BTP2 to block Orai channels resulted in a reduction of action …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… blunted growth response (p<0.05) to TAC-mediated pressure-overload stress as determined by heart weight to body weight ratios Ventricular chamber size and contractile performance were preserved in response to TAC in Ralgds-/- mice. Interestingly, TAC-induced activation of the fetal gene program …
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Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy
… of moderate concentrations of TF, induced by pressure overload observed during early hypertrophy, result in an enhanced rate of cellular turnover, and combined with hypertrophic growth, leads to alterations in heart structure. In contrast, higher concentrations of TF at later stages of disease …
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Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
… In the first study, the effects of iron overload on autophagy in skeletal muscle were observed. Iron toxicity is associated with reduced circulating adiponectin level and increased the diabetes mellitus incidences. Chronic iron overload altered the autophagy regulatory signaling mTOR, …
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A STICKY SITUATION: ESSENTIAL ROLES OF ADHESION G PROTEIN COUPLED RECEPTORS ADGRF5 AND ADGRG1 IN CARDIAC HOMEOSTASIS AND FAILURE
… time. Importantly, when subjected to chronic pressure overload, the deletion of ADGRG1 in CMs accelerated the onset of cardiac dysfunction, accompanied by reduced CM hypertrophy, heightened cardiac inflammation, and increased mortality. These findings suggest that ADGRG1 plays a crucial role …
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