Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Presenilins"”.
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Presenilins Modulate Cellular Activity of Ryanodine Receptors
Payne, Andrew J., Presenilins Modulate Cellular Activity of Ryanodine Receptors. Doctor of Philosophy (Biomedical Sciences), December, 2012, 160 pp., 7 tables, 39 figures, bibliography 241 titles. Ryanodine Receptors (RyRs) are large, endoplasmic reticulum (ER) intracellular calcium channels in …
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Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak
… factors for developing AD are age, mutations in presenilins (PS1 and PS2), mutations in the amyloid precursor protein (APP), cardiovascular diseases, open heart surgery, diabetes, brain injury/head trauma, Apolipoprotein E-e4 (APOE-e4) and the (P86L) mutation in the CALHM1(Calcium homeostasis …
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Novel Optical Tools to Investigate Presenilin Control of Neurotransmission
… we investigate the controversial hypothesis that Presenilins are ER Ca<sup>2+</sup> leak channels to determine if a role in ER Ca<sup>2+</sup> leak can explain the previously described regulation of neurotransmission by Presenilins. While Presenilins are best known for their involvement in …
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Analysis and suppression of mutant sel-12 in Caenorhabditis elegans
… and functionally homologous to the human presenilins, PS1 and PS2. Mutations in the human presenilins contribute to the majority of familial Alzheimer's disease cases. Work in C. elegans also revealed that presenilins are involved in Notch signaling as a reduction of sel-12 presenilin …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
… of the γ-secretase protease complexes, the presenilins are responsible for the cleavage of the amyloid precursor protein (APP) and generation of amyloid beta (Aβ). To date, γ-secretase proteases have over 120 substrates which demonstrate contribution to a diverse range of cellular processes …
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FKBP14 in Notch Signalling and Drosophila Development
Presenilins (PSs) are highly conserved transmembrane proteins that form the catalytic core of the gamma-secretase complex, which cleaves a growing list of transmembrane proteins including Notch and Amyloid Precursor Protein. Autosomal dominant mutations in the genes encoding human PS have been …