Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Prepulse Inhibition"”.
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Ontogeny of Prepulse Inhibition Across Sensory Systems
<p>Prepulse inhibition (PPI), employed as a measure of sensorimotor gating, is operationally defined by the presentation of a weak (prepulse) stimulus immediately prior to a startling stimulus, causing a reduction in the magnitude of the startle response. Alterations in gating are observed in …
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Disruption of Prepulse Inhibition by Apomorphine Across Modalities
… is commonly assessed with manipulations of prepulse inhibition (PPI). Alterations in gating are observed in individuals with schizophrenia, HIV-1 dementia and other neuropsychiatric disorders. Dopaminergic pathways play a putative role in sensorimotor gating. It is well-established that …
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Prepulse inhibition come strumento diagnostico per lo studio del comportamento impulsivo-aggressivo nella schizofrenia
… can be operationally measured through the prepulse inhibition (PPI) of the acoustic startle reflex. Notably, PPI deficits are associated with numerous neuropsychiatric conditions characterized by gating disturbances and personality aggressive traits, including schizophrenia and Tourette …
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Comparison of Auditory Thresholds Obtained with a Conditioned and an Unconditioned Response
… with a sensitive unconditioned procedure, prepulse inhibition, to thresholds obtained using a versatile conditioning procedure, conditioned suppression/avoidance. The results have practical and theoretical interest. Practically, we have found that thresholds obtained with prepulse …
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The effects of noise exposure and genetic background on auditory-evoked behaviors in larval zebrafish
… In chapter 2, I describe a novel paradigm using prepulse inhibition as a tool to measure auditory sensitivity in larval zebrafish. I show that this paradigm is more sensitive than other behavioral measures used in zebrafish research. Next, in chapter 3, I demonstrate that loud noise exposure …
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La clozapine et les neurostéroïdes dans la modulation de comportements associés au suicide dans un modèle murin de schizophrénie
… isolation). In this model, clozapine normalized prepulse inhibition, aggressiveness, impulsivity and anxietylike behaviours in THMS mice. While the basis of clozapine superior effectiveness on suicidal behaviors in schizophrenic patients is not well understood, previous works has revealed that …
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SITUATION MOUSE ALL FLOXED UP: EXPLORING PHENOTYPIC ABNORMALITIES IN BDNF FLOXED MICE
… muscle tone. We repeated the open field and prepulse inhibition (PPI) tests and likewise found increased anxiety, possible motor abnormalities, and severely reduced PPI. This data combined with Brandt’s research provides strong evidence of behavioral abnormalities associated with floxed BDNF …
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Testing the "Interrupt Hypothesis": Does startle disrupt cognitive processing?
… contraction in the face, neck, and shoulders. Prepulse inhibition (PPI) occurs when a stimulus is presented shortly before a startle stimulus resulting in attenuation of the response. Graham (1975) proposed the Interrupt and Protection Hypotheses to explain the role of PPI, positing that PPI …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
… working memory deficit as well as prepulse inhibition deficit in wildtype and heterozygous mice but not in GluN2C knockout mice. These results demonstrate that deficit in GluN2C-containing NMDARs leads to schizophrenia-like phenotypes, and establish that pharmacologic enhancement of …
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Exploring the role of Rapgef6 in neuropsychiatric disorders
… behavioral functions such as startle and prepulse inhibition were also reduced, while locomotion was increased. Hippocampal-dependent spatial memory was intact, as was prefrontal cortex function on a working memory task. Neural activation as measured by cFOS levels demonstrated a reduction …
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Automatic and controlled processing of faces in social anxiety
… in two phases. During the first phase, Prepulse Inhibition of Startle (PPI) was used as an index of attention allocation and attention disengagement in response to the subliminally presented affective faces. During the second phase, a subset of the participants from the first phase …
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Effects of Exposure to Perinatal Ultrasound Radiation on Information Processing in the Auditory System
… motor responses. Acoustic startle and prepulse inhibition tests were administered to test for sensorimotor gating, hearing, and motor response. Finally, a brainstem auditory evoke potential test was given to track auditory threshold and appropriate neural firing at various auditory …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… integration, as well as subtle impairments in prepulse inhibition (PPI). G31P administration did not reverse any of the behavioral deficits caused by polyI:C, although G31P did alter PPI during adolescence. Although the present experiments included replications and novel findings for the …
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Examination of the effect of a diet high in vitamin D in a preclinical model of fragile X syndrome.
… social partition, delayed fear conditioning, nor prepulse inhibition task. There was no difference in weight between groups, but there was a difference in food intake finding that animals on the vitamin D diet consumed more food than animals on the control diet. We also looked at pS6, a downstream …
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Noise-induced cochlear neuronal degeneration and its role in hyperacusis -- and tinnitus-like behavior
… indexed by the acoustic startle response and prepulse inhibition (PPI) of startle. Responses to tones and to broadband noise were measured in mice exposed either to a neuropathic exposure causing primary neuronal degeneration, or to a lower intensity, nonneuropathic noise, and in unexposed …
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P50 Sensory Gating: Impact of High Vs Low Schizotypy Personality and Smoking Status
… sensory gating in schizophrenics, and enhance prepulse inhibition asymmetry (right greater than left) in individuals with schizotypal personality. The purpose of this study was to test the following hypotheses: 1) Individuals with schizotypal personalities have poorer sensory gating than those …
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The role of puberty in the development of the adolescent rodent medial prefrontal cortex and behavior
… showed long-term behavioral deficits on a prepulse inhibition task. These results provide further evidence that pubertal onset is driving many of the behavioral and neuroanatomical changes seen during adolescence, suggesting a specific window during adolescence where the effects of …