Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Prenyltransferases"”.
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Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum
… lipid modification by a prenyl group. Protein prenyltransferases, which catalyze the post-translational prenyl modification, have been established as a target for anticancer therapy. Research done in our laboratory has demonstrated recently that prenyl modification of proteins could be a novel …
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Identifizierung und Charakterisierung von Homogentisat-Prenyltransferasen aus dem Tocopherol- und dem Plastochinon-9-Biosyntheseweg
… of these compounds is catalyzed by homogentisate prenyltransferases located in the inner envelope membranes of chloroplasts. These enzymes use homogentisate derived from the shikimate pathway and prenyl diphosphates synthesized via the plastidial non-mevalonate isoprenoid pathway as substrates and …
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Structural and biochemical studies on tailoring enzymes involved in ribosomal peptides biosynthesis
… the substrate requirements for cyanobactin prenyltransferases, I performed structural study of selected cyanobactin prenyltransferases with isoprenoid donor and various acceptors to illustrate the substrate selectivity. Examination of the substrate spectrum further supported the proposed …
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Studio di componenti del lattice di Euphorbia characias
… homologous to the sequence of several plant cis-prenyltransferases. The results provided novel insight into latex components and will ultimately benefit the broader understanding of E. characias latex composition.
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EXPANDING THE POTENTIAL PRENYLOME: PRENYLATION OF SHORTENED TARGET SUBSTRATES BY FTASE AND DEVELOPMENT OF FRET-BASED SYSTEM FOR DETECTING POTENTIALLY “SHUNTED” PROTEINS
… (GGTase-I), respectively. Both of these protein prenyltransferases recognize a C-terminal "CaaX" sequence in their protein substrates, but recent studies in yeast- and mammalian-based systems have demonstrated FTase can also accept sequences that diverge in length from the canonical four-amino …
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Metabolite biosynthetic enzymes: catalysis, substrate specificity and protein engineering
… acid alters the isoprene donor specificity of prenyltransferases involved in the modification of cyanobactins, a class of RiPPs made by cyanobacteria. Most characterized RiPP prenyltransferases carry out the regiospecific transfer of C5 dimethylallyl donor to the side chain atoms on acceptor …
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Practical applications of genomics to natural product discovery and biosynthesis
… 3, a family of bioinformatically-identified prenyltransferases is investigated that has members in several bacterial pathogens. Starting from genomic data, these terpenoid synthase enzymes are biochemically characterized and found to be functionally divergent from previously identified …