Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Premature ageing"”.
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The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes
The premature ageing syndromes Hutchison-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD) are rare genetic disorders that result in greatly accelerated ageing. RD is neonatal fatal, whereas children suffering from HGPS age approximately 8 times faster than normal individuals and die …
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Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes
… effects on both cellular and mouse models of premature ageing; however, the pathways it is involved in remained largely unexplored. This project set out to identify, characterise and derive mechanistic detail surrounding the functions of NAT10 to better determine its cellular function and …
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Retinal thickness in adults with Down's syndrome: Relationship with age, cognition and dementia
… Down’s syndrome (DS) are known to experience premature ageing and have a high propensity for clinical diagnosis of dementia due to Alzheimer’s disease (AD). In DS there is a unique and natural model of over-expression of amyloid-beta (Aβ) protein, the accumulation of which is proposed to be …
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Investigating the regulation of processing bodies in Drosophila melanogaster oocytes
… by disruptions to their properties can lead to premature bcd translation and impaired embryonic development. To understand how the material properties of P bodies are regulated in Drosophila oocytes, I used a combination of physiological stressors, genetic alterations, and imaging techniques to …
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From youth to old age: therapeutic potential of microbiota interventions in the gut-brain-axis
… the damage to the intestinal barrier due to ageing. The effect was not directly linked to changes in microbial diversity of the gut and did not significantly ameliorate the impaired immune system of the aged animals’ intestine or hippocampus. Only a significant increase in the number of …
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Changes in buccal cytome biomarkers in relation to ageing and Alzheimer’s Disease.
… of genomic instability in relation to normal ageing and premature ageing syndromes such as AD and DS. A buccal micronucleus cytome assay was developed and used to investigate biomarkers for DNA damage, cell proliferation and cell death in healthy young, healthy old and young Down’s syndrome …
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Axis of placental ageing in adverse pregnancy outcomes
… genetic, environmental, or placental factors. Premature ageing of the placenta in pregnancy outcomes such as PE and IUGR is associated with the persistent presence of oxidative stress and placental insufficiency reducing its functional capacity. Placental proteomics has been instrumental in …