Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Premalignant"”.
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Identification of Tissue and Circulating Biomarkers For Premalignant and Malignant Lesions
… and adenocarcinomas. Fold changes of paired premalignant/malignant lesions compared to normal adjacent tissues from the same patient were analyzed. And the ratio of 20-gene panel found in the first project were also found to differ between colorectal adenomas and cancers.</p> <p>The last …
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Sensitivity and Specificity of Detecting Premalignant Pancreatic Lesions by Hyperpolarized Magnetic Resonance
… Papillary Mucinous Neoplasm (IPMN). During these premalignant stages, there is evidence of dysregulated metabolism present in these early lesions, including an increase in lactate production. The overarching goal of this dissertation is to develop the capability of non-invasively detecting these …
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Cell cycle regulatory proteins and miRNAs in premalignant lesions and breast cancer
… revealed changes in miRNA expression in early premalignant breast lesions involved in cell proliferation, and opposing roles in cell migration for a cell cycle-related miRNA in breast cancer subgroup models.
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Identifying mutational landscape and inflammatory pathways associated with lung squamous premalignant lesion progression
… the genomics and immune microenvironment of premalignant lesions (PMLs) that precede the development of LUSC is crucial in order to improve the ability to diagnose disease early and identify intervention strategies to enhance the prognosis of lung cancer. As part of this thesis project, my …
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Immunogenetic analysis of HLA Class II in premalignant disease of the cervix and correlation with HPV status
The human papilloma virus (HPY) infection has a causal association with cervical intraepithelial neoplasia (CIN) and cervical cancer. However, pre-malignant or malignant transformation is not always observed with HPY infection. lILA molecules are important in the regulation of the immune response …
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Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
<p>Mammary ductal carcinoma in situ (DCIS) is being found in great numbers of women due to the widespread use of mammography. The molecular and genetic changes underlying the progression from normal breast tissue to DCIS are not clearly understood. The goal of the present study was to determine …
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The impact of positive margins and crypt involvement in excisional procedures of the cervix on recurrence rates of premalignant diseases of the cervix
… involvement increased the rate of recurrence of premalignant disease in patients who had excisional procedures. METHODS In this retrospective review of the colposcopy database, patient records and pathology database, women who had cervical excisional procedures at the Groote Schuur Hospital …
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The battleground of two Infections and a cancer: Human Papilloma Virus, premalignant lesions of the cervix and their interaction with Human Immunodeficiency Virus in southwestern Nigeria
… the effect of HIV infection on the burden of premalignant lesions of the cervix; assess the diagnostic accuracy of direct visual inspection of the cervix; and contribute to policy formulation and the development and implementation of effective cervical cancer prevention and control programme …
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Genomic and Transcriptomic Landscape of Colorectal Premalignancy
… efforts to systematically characterize premalignant lesions at the molecular level, which could lead to a better understanding of neoplastic initiation, risk prediction, and the development of targeted chemoprevention strategies. The challenge in characterizing premalignancy has always …
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Assessing the psychosocial impact of monoclonal gammopathy of undetermined significance (MGUS)
… of undetermined significance (MGUS) is a premalignant plasma cell disorder which precedes multiple myeloma (MM), an incurable blood cancer. To date, limited research has focused on the psychosocial impact of receiving a MGUS diagnosis. This dissertation reports the findings from an …
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Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models
… models suggests that pre-degenerative and premalignant abnormalities include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal transduction pathways affected in both degenerative and neoplastic disease states …
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Computational Genomic Models For Spatio-Temporal Investigation of Early Lung Cancer Pathology
… A comprehensive molecular characterization of premalignant lesions and tumor-adjacent normal tissue can aid in better understanding NSCLC pathogenesis. However, these investigations are further challenged by limited tissue availability and low cellular fractions of detectable somatic …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… DCIS formation by enhancing cancer stemness of premalignant cells. On the other hand, we compared the DCIS.com and invasive breast cancer cell line, MCF10CA, and identified INHBA and GJB2 as novel regulators of aggressive phenotype. These 2 genes regulated migration, colonization and stemness of …
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Branching process models for cancer evolution: overview and an application to colorectal cancer initiation
… We derive analytic estimates for the sizes of premalignant subpopulations, and use these results to compute the waiting time distributions of novel driver mutations.
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Evaluation of ambulatory diagnosis of abnormal uterine bleeding
… / ultrasonography in the identification of premalignant and malignant endometrial lesions? • What is the relative significance of hysteroscopic and ultrasonographic evidence of endometrial atrophy in relation to an insufficient sample on outpatient endometrial biopsy? • What is the risk of …
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Development of Electrochemical Immunosensor for Oral Cancer: Initial Outcome
… malignant transformation in patients with oral premalignant disorders such as OL. However, further research involving clinical samples and larger datasets is necessary to establish the sensor's diagnostic accuracy and real-world applicability.
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
… we report CBS expression upregulation begins in premalignant colonic specimens. Additionally, forced upregulation of CBS in an adenoma-like colonic epithelial cell line (NCM356) is sufficient to induce increased NCM356 cell bioenergetics, proliferation, invasion through Matrigel, resistance to …
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Targeting CDK to Prevent and Treat Retinoblastoma and other Cancers
… Phase II clinical trials. Since expansion of premalignant cells is critical for tumor establishment, we wondered whether CDK inhibitors would be more effective in prevention than treatment. To examine this, we leveraged pharmaceutical and genetic strategies to demonstrate that initiated …
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The role of seminal plasma in the regulation of inflammation and inflammatory pathways in the cervix: potential for cervical cancer progression and HIV transmission in South African women
… cancer suggesting that cervical cancer and premalignant cervical lesions may increase transmission and acquisition of HIV infection. Seminal plasma (SP) has been shown to initiate inflammatory response within the female genital tract. Exposure of neoplastic cervical epithelial cells to SP …
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