Global ETD Search
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Showing 1 to 5 of 5 for “"Prelamin A"”.
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Role of Zmpste24 in Prelamin A Maturation.
… A, is first synthesized as a 74 kDa precursor, prelamin A. Following the endopeptidase and methylation reactions which occur after farnesylation of the CAAX-box cysteine, there is a second endoproteolysis that occurs 15 amino acids upstream from the C-terminal farnesylated cysteine residue. …
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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
… form among them. LA is initially synthesized as Prelamin A (PreA), and undergoes a series of modifications that truncate the protein to produce “mature” LA. Existence of the precursor form, and its complex maturation pathway, have puzzled researchers since their realization. With a pattern of …
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Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing
… Metallprotease prozessiert das Zellkernprotein prelamin A durch endoproteolytische Entfernung der carboxyterminalen 16 Aminosäuren zu reifem lamin A. Die Unterdrückung dieser proteolytischen Spaltung des prelamins A durch RNAi gegen FACE1 resultiert in der Akkumulation von nicht prozessiertem …
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Identificazione delle Lamine di tipo A come nuovi substrati della protein chinasi Akt/PKB
… the cell cycle, phosphorylation of the precursor prelamin A becomes detectable as cells enter the G2 phase, picking at G2/M. This study also shows that lamin phosphorylation by Akt creates a binding site for 14.3.3 adaptors which, in turn, promote prelamin A degradation. While this mechanism is in …
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The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes
… which has a vital role in the processing of prelamin A. The mutation results in the accumulation of immature prelamin A at the nuclear membrane. As a result of increased understanding of the defects in HGPS arising from LMNA mutations a number of therapeutic routes are currently being …