Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Pregnane X Receptor"”.
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
… ligand activated transcription factor retinoid X receptor (RXR) forms a DNA binding heterodimer with pregnane X rseceptor (PXR) in response to foreign xenobiotics. In addition to RXR and PXR there are other proteins involved in the RXR/PXR signaling pathway. Many proteins involved in this pathway …
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
<p>The pregnane X receptor (PXR or SXR; NR1I2) is a member of the nuclear receptor superfamily. It activates the transcription of a large network of genes including cytochrome P450 (CYP) and Mdr1 which play critical roles in chemicals metabolism and transportation. Induction of CYPs contributes to …
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Chemical mixtures and interactions with detoxification mechanisms and biomarker responses in fish
… due to shared elimination pathways or receptor interactions, can result in possible adverse outcomes in animals. This thesis investigates how detoxification mechanisms are affected by exposure to chemicals alone or in mixtures. Cytochrome P450 (CYP) enzymes and efflux pumps have key …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… in diseases associated with inflammation. Pregnane X receptor (PXR) and nuclear factor-κB (NF-κB) are regarded as key transcriptional factors that are modulated in response to endotoxin and cytokine signaling. This work assesses the role of NF-κB and PXR in the transcriptional regulation of …
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Vom Antioxidanz zum Genregulator : transkriptionelle Regulation von Phase I- und Phase II-Enzymen durch Vitamin E und antioxidative sekundäre Pflanzeninhaltsstoffe
… untersuchen. Dazu wurde die Aktivierung des PXR (pregnane X receptor) und des Nrf2 (NF-E2-related factor-2) als zentrale Transkriptionsfaktoren der Phase I- bzw. Phase II-Enzyme getestet. Der Einfluss von verschiedenen Vitamin E-Formen und antioxidativen Pflanzeninhaltsstoffen in Form von …
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Regulation of P-glycoprotein at the Blood-Brain Barrier
… not affect tight junctions. Sarafotoxin, an ET-B receptor agonist, also reduced P-gp-mediated transport; the effects of ET-1 and sarafotoxin were blocked by an ET-B receptor antagonist, but not by an ET-A receptor antagonist. Immunostaining localized the ET-B receptor to the luminal and abluminal …
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Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
… also characterized the ontogeny of four nuclear receptors through measurement of their gene expression. Nuclear receptors belong to a highly conserved gene superfamily of transcriptional factors that regulate the expression of their target genes, many of which include members of the ABC …
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Vitamin E : elucidation of the mechanism of side chain degradation and gene regulatory functions
… of metabolizing enzymes like CYP3A4, a pregnane X receptor (PXR)-based reporter gene assay was chosen. PXR is a nuclear receptor which regulates the transcription of genes, e.g., CYP3A4, by binding to specific DNA response elements. And indeed, as shown here, vitamin E is able to …