Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Pregnane X Receptor"”.
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
… ligand activated transcription factor retinoid X receptor (RXR) forms a DNA binding heterodimer with pregnane X rseceptor (PXR) in response to foreign xenobiotics. In addition to RXR and PXR there are other proteins involved in the RXR/PXR signaling pathway. Many proteins involved in this pathway …
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Studying the Specificity of hPXR Antagonists Using a Panel of Cell-based Assays
<p>The pregnane X receptor (PXR or SXR; NR1I2) is a member of the nuclear receptor superfamily. It activates the transcription of a large network of genes including cytochrome P450 (CYP) and Mdr1 which play critical roles in chemicals metabolism and transportation. Induction of CYPs contributes to …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… in diseases associated with inflammation. Pregnane X receptor (PXR) and nuclear factor-κB (NF-κB) are regarded as key transcriptional factors that are modulated in response to endotoxin and cytokine signaling. This work assesses the role of NF-κB and PXR in the transcriptional regulation of …
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Vom Antioxidanz zum Genregulator : transkriptionelle Regulation von Phase I- und Phase II-Enzymen durch Vitamin E und antioxidative sekundäre Pflanzeninhaltsstoffe
… untersuchen. Dazu wurde die Aktivierung des PXR (pregnane X receptor) und des Nrf2 (NF-E2-related factor-2) als zentrale Transkriptionsfaktoren der Phase I- bzw. Phase II-Enzyme getestet. Der Einfluss von verschiedenen Vitamin E-Formen und antioxidativen Pflanzeninhaltsstoffen in Form von …
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Regulation of P-glycoprotein at the Blood-Brain Barrier
… not affect tight junctions. Sarafotoxin, an ET-B receptor agonist, also reduced P-gp-mediated transport; the effects of ET-1 and sarafotoxin were blocked by an ET-B receptor antagonist, but not by an ET-A receptor antagonist. Immunostaining localized the ET-B receptor to the luminal and abluminal …
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Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
… also characterized the ontogeny of four nuclear receptors through measurement of their gene expression. Nuclear receptors belong to a highly conserved gene superfamily of transcriptional factors that regulate the expression of their target genes, many of which include members of the ABC …
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Vitamin E : elucidation of the mechanism of side chain degradation and gene regulatory functions
… of metabolizing enzymes like CYP3A4, a pregnane X receptor (PXR)-based reporter gene assay was chosen. PXR is a nuclear receptor which regulates the transcription of genes, e.g., CYP3A4, by binding to specific DNA response elements. And indeed, as shown here, vitamin E is able to …