Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 465 for “"Prefrontal cortex"”.
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Dopaminergic modulation of prefrontal cortex subpopulations
… abundant evidence that dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioral functions, the precise circuit computations remain elusive. One potentially unifying theoretical model by which dopamine can modulate functions from working memory to schizophrenia is …
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The connectivity of the mammalian prefrontal cortex
The fine scale connections of prefrontal cortex (PFC) were investigated in the rat brain, in order to determine organizational properties of PFC pathways which were previously undefined. Neuroanatomical tract tracers (Fluro-Gold, Fluoro-Ruby, Fluoro-Emerald, Biotinylated dextran amines; Fluorescein …
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Binge Alcohol Effects on the Prefrontal Cortex
… by binge alcohol consumption is the frontal cortex, an area important for many functions and decision making of daily life. Loss of prefrontal grey matter resulting from heavy alcohol consumption has been documented, however this volume loss does not appear to be caused by a decrease in the …
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Multi-item memory in the primate prefrontal cortex
… the activity of neurons from the lateral prefrontal cortex during task performance. We found that the majority of neurons showed delay activity that depended on the identity of both images (a minority reflected just one image), and that activity related to a given combination of images was …
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Variability of Neural Responses in the Lateral Prefrontal Cortex
… which the stimulus is absent. The dorsolateral prefrontal cortex has long been implicated as the seat of visuospatial working memory, and undergoes dramatic increases in volume and functional connectivity during and around the time of puberty. However, much of the neurophysiological changes …
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Processing of relevant information in the primate prefrontal cortex
… ventral to the principal sulcus of the lateral prefrontal (PF) cortex in two monkeys (macacca mulatta). Activity was assessed during the performance of three visual memory tasks. In the first task, the sensory and mnemonic receptive fields were studied, by requiring monkeys to simultaneously …
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Role of rat medial prefrontal cortex in time interval estimation
… lines of evidence suggest the involvement of prefrontal cortex in time interval estimation. The underlying neural processes are poorly understood, however, in part because of the paucity of physiological studies. The goal of this study was to test the requirement of intact medial prefrontal …
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Investigating prefrontal cortex neuronal signatures of opioid-induced risk-taking behavior
… neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. …
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Impact of Acute Ethanol Injections on Medial Prefrontal Cortex Neural Activity
The medial prefrontal cortex (mPFC) is a cortical brain region involved in the evaluation and selection of motivationally relevant outcomes. mPFC-mediated cognitive functions are impaired following acute alcohol exposure. In rodent models, ethanol (EtOH) doses as low as 0.75 g/kg yield deficits in …
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The role of the prefrontal cortex in hypnotic and placebo analgesia.
… and that whilst placebo effects rely on the prefrontal cortex (PFC; Benedetti, 2010), the role of the PFC in hypnosis and hypnotic suggestibility is inconclusive. Methods: Fifty-four participants (27 male) performed tasks known to tap either left (the Stroop Task; Stroop, 1938), right (the …
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The Impact of Early Life Adversity on Mediodorsal Thalamic-Prefrontal Cortex Maturation
… of cognitive and affective behaviors is the prefrontal cortex (PFC) which receives inputs from various brain regions, including the mediodorsal thalamus (MD), and undergoes a protracted maturation. Thus, it’s conceivable that ELA exposure during a sensitive window of MD development may …
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The Role of the Ventromedial Prefrontal Cortex in Mnemonic Discrimination and Generalization
The ventromedial prefrontal cortex (vmPFC) is involved in generalizing across similar items and events, working with hippocampally mediated processes that discriminate between those items and events at encoding. These complementary processes may, in turn, contribute to confidence signals regarding …
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Role of prefrontal cortex and cholinergic modulation in attentional performance in rats
The present thesis investigates the role of the prefrontal cortex and cholinergic modulation in attentional performance, and to a lesser extent, inhibitory response control, in rats. A greater understanding of these functions is important for the effective treatment of attentional and impulsive …
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A non-human primate model of dorsolateral prefrontal cortex dysfunction in schizophrenia
… supporting SWM, principally the dorsolateral prefrontal cortex (dlPFC). One of these changes in schizophrenia is a loss of perineuronal nets (PNNs), extracellular matrix structures that serve to protect and support the function of neurons, within the dlPFC (Mauney et al., 2013). Our aim was to …
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Regulating the anterior medial prefrontal cortex : exploratory investigation of real-time fMRI training
… the level of activation in rostromedial prefrontal cortex (rMPFC) to learn improved regulation of this brain area was examined in a group of 5 young adults. Subjects received real-time feedback from the target brain region while engaging in a blocked-design task involving alternating …
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Measuring prefrontal cortex response to virtual reality exposure therapy in freely moving participants
… therapy normalise brain activity within a prefrontal - amygdalar fear circuit after the treatment. However, the previous studies employed technologies that perhaps impact on ecological validity and naturalness of experience. Moreover, there are no studies investigating what is happening in …
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Medial temporal lobe and prefrontal cortex contributions to memory expressed on short timescales
… representations. In contrast, the role of the prefrontal cortex (PFC) in memory on this timescale has been well studied. One consequence of new insights about the role of MTL in memory under short delays is the question of how PFC fits into the picture. The framework for the work performed here …
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THE EFFECTS OF WORKING MEMORY TRAINING ON THE FUNCTIONAL SPECIALIZATION OF THE PREFRONTAL CORTEX
The dorsolateral prefrontal cortex (PFC) has long been associated with the performance of working memory tasks; however the functional specialization of this area has been debated. Several studies have identified differences in stimulus property selectivity along the dorsal-ventral axis. …
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