Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Predictive biomarkers"”.
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Understanding the reproductive biology of giant pandas: predictive biomarkers for reproductive success
… to determine if potential new reproductive biomarkers can be identified. Metabolism and reproduction are linked, with female giant pandas showing altered metabolism at key reproductive periods. Metabolism also influences urinary biomarker correction, and urinary specific gravity (USpG) has …
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Identification of Early Diagnostic and Predictive Biomarkers of Cisplatin-Induced Acute Kidney Injury Using Metabolomics
… elevated after significant kidney injury. Novel biomarkers are necessary for early diagnosis of cisplatin-induced AKI and to identify high risk patients prior to cisplatin therapy. Untargeted metabolomics was utilized to characterize the metabolic alterations induced by cisplatin in a mouse model …
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The Microsatellite Instability High Endometrial Tumor Microenvironment and Identifying Predictive Biomarkers of Response to Pembrolizumab
… analyzed by Exome Capture RNA-seq to identify predictive immuno-genomic signatures associated with treatment response. Multipanel immunofluorescent panel testing was performed on samples in the treated cohort. Results: In the untreated cohort (n=11), the transcriptomic profiles of the samples …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… gamma receptors thus represent clinically useful predictive biomarkers for the efficacy of antibodies targeting receptors found on monocytic AML and other hematologic malignancies. Appropriate use of these biomarkers will help clinicians better identify patients who will respond to these …
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Discovery and Development of Predictive Biomarkers for the Personalization of Pemetrexed Therapy in Non-Small Cell Lung Cancer
Lung cancer is a major health problem, and is the leading cause of cancer-related deaths. This research proposal was designed to personalize and improve overall response rates to the FDA-approved chemotherapeutic pemetrexed. To do so, clinically-applicable response phenotypes of a large panel of …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… (ICB), and developed an approach to identify predictive biomarkers of responsiveness to ICB. First, we developed a novel TME-activated polymeric material that can be conjugated with a class of anti-hypertensive drugs to target tumor desmoplasia, enhance anti-tumor activity of T-lymphocytes, …
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Decoding Treatment Resistance and Genotype-Phenotype Interactions at Single Cell Resolution
… of EAC CRT responses and identified novel predictive biomarkers and actionable targets to enhance CRT efficacy. Another important biological question is whether the intra-tumor heterogeneity (ITH) in cancer cell gene expression programs stem from genomic alteration events, or alternatively, …
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An Integrated Bioinformatics Approach for the Identification of Melanoma-Associated Biomarker Genes. A Ranking and Stratification Approach as a New Meta-Analysis Methodology for the Detection of Robust Gene Biomarker Signatures of Cancers.
… the systematic discovery of diagnostic biomarkers of cancers and other pathologies. However, meta-analyses of published arrays using melanoma as a test cancer has uncovered significant inconsistences that hinder advances in clinical practice. In this study a computational model for the …
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Proteomic Signatures of Type 2 Diabetes and Related Metabolic Traits
… that improved interpretation of disease biomarkers and candidate mediators. To assess the integrated whole-body response to high glucose ingestion, I systematically characterised protein changes during an oral glucose tolerance test (OGTT). Around 11% of the measured proteome changed …
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Assessing the economic case for stratified medicine
… and companion diagnostics. I hypothesize that predictive biomarkers can generate economic value in drug development by increasing success rates. I construct an economic model of the development of a hypothetical new therapy, and devote particular attention to parameters regarding safety, …
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Putting the Body Back Together: A Functional Autonomic Model of Interoception
… including a call for more integrative and predictive biomarkers for interoceptive ability. While there is a robust literature purporting to measure interoception, there is also significant research challenging the content validity of the current methodology. Beyond these published …
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Predicting Patient Outcomes in the EPOCH Clinical Trial
… Imaging (MRI) scans paired with patient biomarkers. Multi-Dimensional Subset Scanning (MDSS) identified a group of patients with shared biomarkers that exhibited poor response to TARE, and Cox Proportional Hazards (CoxPH) modeling revealed hazard ratios for biomarkers aligning with …
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The perioperative setting as a platform for breast cancer biomarker development
… positive breast cancer. The identification of predictive biomarkers of response to systemic therapy is of great research interest, as this may allow treatment to be tailored to the individual. Pathologic complete response (pCR), the absence of residual invasive carcinoma in the breast or …
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CRISPR/Cas9 screenings and in silico investigations nominate low-frequency alterations in DNA repair genes as biomarkers for castration-resistant prostate cancers.
… that could represent potential targets or biomarkers for mCRPC therapy. We exploited an interdisciplinary approach based on in vitro studies including CRISPR/Cas9 genotoxic screenings and on in silico analyses focused on mCRPC patients’ genomic and clinical data. The screenings were …
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Insulin-like growth factor receptor activity in cancer biology & therapy responses
… clinical trials owing to a lack of efficacy and predictive biomarkers. IGF-1R activity and signalling in cancer cells is regulated by its C-terminal tail, and in particular, by a motif that encompasses tyrosines 1250 and 1251 flanked by serines 1248 and 1252 (1248- SFYYS-1252). Mutation of …
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Immune biomarkers predicting clinical outcomes for major trauma patients
… activity within the CARS response may act as a predictive biomarker of late MODS and poor clinical outcome. This study aims to analyse the trends of 7 subsets of T lymphocytes; CD3+, CD4+, CD8+, CD25BRI, CD4+FOXP3+, CD25BRIFOXP3+, and CD127LOWFOXP3+ following major trauma, in the hopes of …
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Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
… profiles of clinically relevant robust biomarkers using a 63 tumour breast cancer cohort. Automated quantitative analysis of protein expression in human breast cancer specimens, including target genes of Stat3 and Stat5, cyclin D1 and p21, are statistically similar to manual scoring, and …
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ANTIBODY-DRUG CONJUGATES FOR THE TREATMENT OF BREAST CANCER.
… For both ADCs, however, we lack effective biomarkers to predict outcomes from pre-treatment samples. Methods: To unveil predictive biomarkers for ADCs, we first evaluated 5-year outcomes in a prospective trial (ATEMPT) testing adjuvant T-DM1 in patients with stage I HER2+ breast cancer, and …
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Precision Medicine in Immunotherapy and Lung Cancer
… cell lung cancer, and combines potential biomarkers from simple immunohistochemistry to advanced single-cell RNA sequencing data to predict immunotherapy toxicity. Outline The first chapter of this thesis explores the role of immunohistochemistry markers for Activin-A, GDF-11 and TGF-B as …
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