Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 131 for “"Precursor cells"”.
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Characterization of human adipose tissue-derived adult multipotent precursor cells
… existence of a putative subpopulations of stem cells in the adipose tissue stroma. These adipose derived stem cells (ADSCs) under certain conditions express characteristics of various mesenchymal lineages. This thesis showed that 1,25a??dihydroxyvitamin D3 worked synergistically with …
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Characterization of subtypes of precursor cells in the developing central nervous system
The role of radial glial cells as guides for migrating neurons is well established, whereas their role as precursor cells is less understood. Here we examined the composition of radial glial cells and their proliferation in the mouse telencephalon during development. We found that almost all radial …
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Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
… mice, I was able to trace Mash1 expressing cells to neurons and oligodendrocytes in the adult mouse, but tracing to astrocytes was never observed. These data refute the conventional understanding that Mash1 is purely pro-neuronal, and is consistent with recent findings of Mash1 descendents …
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The Effect of Hypergravity (2g) on Osteoblast Precursor Cells in the Periodontal Ligament of the Rat
… effect of weightlessness on bone and osteoblast precursor cells has previously been studied. A marked decrease in bone formation, an increase in less differentiated committed osteogenic cells (A+A'), and a decrease in preosteoblast cells (C+D) was noted. To date, the effect of hypergravity (2g) …
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Genome-Wide Localization And Novel Deposition Pathways Of Histone Variant H3.3 In Embryonic Stem And Neuronal Precursor Cells
… in pluripotent mammalian embryonic stem (ES) cells, and I establish the dependence and independence of these patterns on the histone chaperone Hira. To distinguish H3 variants, I use designed zinc finger nucleases (ZFNs) to rapidly knock epitope tags into a single allele of the endogenous …
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Investigating the role of cell-autonomous ROS status in the regulation of hippocampal neural precursor cells in adult mice
… entails a continued recruitment of neural precursor cells (NPCs) into active cell cycle and their progressive transition into post-mitotic granule cells. These adult born neurons integrate into the existing circuitry and confer structural plasticity, which aids in key hippocampal functions. …
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Detailed analysis of Lmx1b expression in multiple organs and its role in dorso-ventral patterning with emphasis on myogenic precursor cells
… development and restricted to luminal epithelial cells. Mice targeted for Lmx1b lack mammary glands. These findings indicate that Lmx1b plays a pivotal role in mammary gland development. Indeed, female patients with NPS display poor breast development (Sweeney et al. 2003). It is shown that Lmx1b …
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Chemical Genetic Interrogation of Neural Stem Cells: Phenotype and Function of Neurotransmitter Pathways in Normal and Brain Tumor Initiating Neural Precursor Cells
… of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain brings promise for the treatment of neurological diseases and has yielded new insight into brain cancer. The complete repertoire of signaling pathways that governs these cells however remains largely …
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Automated Identification and Tracking of Motile Oligodendrocyte Precursor Cells (OPCs) from Time-lapse 3D Microscopic Imaging Data of Cell Clusters in vivo
… into the migration of Oligodendrocyte precursor cells (OPCs) and its role in the central nervous system. However, current practice of image-based OPC motility analysis heavily relies on manual labeling and tracking on 2D max projection of the 3D data, which suffers from massive human …
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Sox2 co-occupies distal enhancer elements with cell-type-specific POU factors to specify cell identity in embryonic stem cells and neural precursor cells
… states, that of pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs), but what common or distinct roles Sox2 may play in these cell types not fully understood. Further, the molecular mechanisms by which Sox2 can specify two distinct cell identities are as of …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… and proliferating neural stem/progenitor cells (NSCs) through the processes like neurogenesis and gliogenesis [1]. In the developed mammalian brain these NSCs have been found to be restricted to limited regions called neurogenic niches [2]. These neurogenic niches provide microenvironments …
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The role of the C. elegans transcription factor LIN-11 in cell fate specification
… developmental system in which three vulval precursor cells divide, generating the 22 nuclei that form the functional wild type vulva. Additionally, the combined formation of the vulva and the uterus is a model for organogenesis. Hermaphrodites homozygous for a lin-11 mutation are unable to …
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Stem cells and neoplasia a study of acquired melanocytic naevi
… may arise from a mutated tissue-resident precursor cell, and not froma terminally differentiated melanocyte. The overall aim of this study was to investigate whether benign naevi contain cells with a stem cell-like phenotype, and to examine the question of whether these might be stem cell …
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Development of the ocular motor system in mouse embryos
… out to and spreads out within a mass of muscle precursor cells expressing the myogenic determinants Pitx2 and Myf5 near the eye. Contact between nerves and muscle precursors occurs days before mature muscle fibers have formed. The nerve remains in a plexus with these muscle precursor cells past …
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Mosaic Analysis with Double Markers (MADM) as a Method to Map Cell Fates in Adult Mouse Taste Buds.
… embedded in the oral epithelium composed of cells that undergo continuous replacement. Mature taste cells live on average 10-14 days and are replaced by new cells when they die. However, the mechanism by which taste cells are produced and integrated into the taste bud as mature taste cells …
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The genetic analysis of the vulval cell lineages of Caenorhabditis elegans
… During vulval development, six equipotentlal cells of the ventral hypodermis respond to an inductive signal from the gonadal anchor cell to adopt one of three fates dependent upon position. Thus, the vulva is a model system to study the processes of induction and pattern formation at the level …
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Regulatory Proteins in Progenitors and Differentiated Cells of the Human Prostate
… proteins in mature and differentiating cells of the adult prostate, including the benign and malignant prostate. In this thesis, I provide evidence for epithelial renewal in response to prostate tissue culture, and for basal and epithelial stem cell (SC) recruitment leading to an …
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Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
… the role of extraocular muscle (EOM) progenitor cells in sparing the muscles from pathology associated with Duchenne Muscular Dystrophy (DMD). Mouse models of muscular dystrophy and wild type mice were analyzed by flow cytometry and cell culture for the size, heterogeneity and functional …
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