Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 116 for “"Preclinical studies"”.
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LOCOREGIONAL DELIVERY OF UNMETHYLATED CPG-OLIGODEOXYNUCLEOTIDES TO CANCER THERAPY: PRECLINICAL STUDIES
… and well tolerated, and might represent a preclinical basis for the design of clinical studies, even considering the ability of CpG-ODN to down-modulate DNA repair genes in tumor cell.
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
Telomerase is expressed in ~90% of all cancers but is not expressed in most somatic cells making it an attractive target for cancer therapy. Telomerase has two essential components, a reverse transcriptase (hTERT) and an RNA template (hTR or hTERC). The RNA template is used by the reverse …
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Preclinical Studies of A Novel Idh1 Inhibitor In Acute Myeloid Leukemia (Aml)
<p><strong><strong>LY3410738, </strong>a novel covalent Isocitrate Dehydrogenase 1 (IDH1) inhibitor in Acute Myeloid Leukemia, it</strong> <strong>is more effective than Ivosidenib (AG120) and has a potent anti-leukemic effect against IDH1 mutant acute myeloid leukemia in combination with …
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Monte Carlo simulations, in vitro and in vivo experimental verifications for preclinical studies
… cancer research, pre-clinical in vivo studies using small animals have become indispensable in bridging the gap between in vitro cell experiments and clinical implementation. When setting up such small animal experiments, various biological, technical and methodical aspects have to be …
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Passive Acoustic Mapping of Microbubbles in Focused Ultrasound Induced Brain Therapies for Preclinical Studies
… explore new brain therapies for clinical uses, preclinical studies in rodent models with precise anatomical targeting and monitoring must be conducted. This thesis discusses the development of a high-resolution transmit-receive FUS array with a novel broadband receiver designed to conduct BBBM …
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COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS
… through inhibition of EZH2 protein to date, the preclinical study of DZNep was thus performed. No observable adverse effect dose (NOAEL) of DZNep determined was 10 mg/kg in Sprague Dawley (SD) rats. DZNep caused nephrotoxicity and renal atrophy in rats in a dose-dependent manner but had no …
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Injectable Systems for Long-Lasting Insulin Therapy
… of insulin for days to weeks in in vitro and preclinical studies. Several of these delivery systems have further advanced to clinical trials for once-weekly insulin injection to treat diabetes. Although a number of review articles have appeared in the literature to discuss the developments of …
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Regulatory issues concerning the preclinical testing of synthetic peptides
… molecules and biological products as to which preclinical studies are to be conducted. Synthetic peptides present a unique scenario in which a case-by-case approach is needed for the conduct of preclinical studies. For peptides containing components that are already tested for genotoxicity, it …
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Advancing the Preclinical Development of Secondary Metabolites from Cacospongia mycofijiensis for the Treatment of Cancer
… availability has resulted in a paucity of studies aimed at advancing the preclinical development of these secondary metabolites from <em>C. mycofijiensis </em>for the treatment of two cancers in need of additional effective therapeutics.<em> </em></p> <p>The three lead chemotypes derived …
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NEAR INFRARED SPECTROSCOPIC ASSESSMENT OF BONE WATER BINDING TO COLLAGEN AND MINERAL
… of bone mineral density (BMD); however, studies have shown that other factors such as bone architecture, cell turnover and tissue composition influence bone quality. There is growing evidence that age related changes in bone water associated with collagen and/or mineral have a direct …
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Orthotopic liver metastasis mouse models of mismatch repair-proficient colorectal cancer recapitulate clinical inefficacy of immune checkpoint blockade
… commonly used mouse syngeneic CRC cell lines in preclinical studies of colorectal cancer. In most of these preclinical studies, MC38 and CT26 are implanted under the skin in the hind flank of the mice where they grow into subcutaneous tumors. Several studies have shown that these subcutaneous …
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Exploring SARM1 as a target to delay programmed axon degeneration
… be activated in human painful neuropathies and preclinical evidence suggests it is also active in neurodegenerative conditions, such as Parkinson’s disease and Amyotrophic Lateral Sclerosis. Programmed axon degeneration is a potentially druggable pathway with preclinical studies showing that …
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A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model
… vitro characterization of this model has enabled preclinical studies of this promising glioblastoma therapy in an immunocompetent rat model, an important step before advancing ultimately to clinical human trials.
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Exercise mitigates chemotherapy-induced cognitive impairment in a mouse model of breast cancer.
… of hippocampal neurogenesis. Previous studies have demonstrated that cancer likely plays into the suppression of neuronal proliferation in the hippocampus as well, which is explored further in this study. This is important as literature has reported that neurogenesis enhances cognitive …
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Multi-parametric photoacoustic/ultrasound localization (PAUL) imaging and its applications
… versatile, and functional imaging platform for preclinical studies, offering new opportunities to probe vascular dynamics, tissue physiology, and therapeutic responses in vivo.
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THE USE OF PREVENTATIVE CANNABIDIOL, CANNABIGEROL, AND MITRAGYNINE TO AMELIORATE MECHANICAL SENSITIVITY OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY IN FEMALE MICE
… prescription pharmaceuticals, pharmacological studies have favored medicinal plant–based analgesic therapies, anticipating that these approaches could offer effective pain relief. These preclinical studies have demonstrated the antiallodynic effects of Cannabidiol and Cannabigerol from Cannabis …
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
… cells evading targeting. Unfortunately, most preclinical studies evaluating CAR T cells in glioblastoma use tumors expressing a single antigen, xenografts, and/or lymphodepletion. While lymphodepletion enhances CAR T cell efficacy, it diminishes the endogenous immune system, which has the …
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Multimodal imaging monitoring of key physiological changes of peripheral arterial disease
… studied, there is still a large gap between preclinical research and clinical translation. This is due in part to the lack of research standardization in preclinical studies, an inadequate resemblance of the animals’ model to the actual disease in humans, and the complexity of the disease’s …
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Identification and Knockout of Immunodominant Endogenous Retroviral Antigen in Murine Tumor Models
… cells. Murine tumor models commonly used for preclinical studies B16F10, MC38, 4T1, and CT26 were able to produce replication-competent eMLV able to infect other murine cells in vitro and T cells in vivo. Human tumors have not been shown to produce infectious ERV, and so we removed the …
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Preclinical Investigations Of Genetic Correlates Of Alcohol Use Disorder
… has been done to characterize its genetic basis. Preclinical studies have been critical in describing the functional significance of genes associated with AUD and have advanced our understanding of the neurobiological underpinnings of this disorder. This dissertation presents a collection of mouse …
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