Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Preclinical research"”.
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Sex as a Biological Variable in Preclinical Animal Studies with an Infectious Disease Exemplar.
… has historically been overlooked in biomedical research, creating a critical gap in our understanding of how sex influences physiological and therapeutic outcomes. This is particularly important in infectious diseases such as Clostridioides difficile infection, where sex has been identified as …
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Building the Bridge from Bench to Bedside: Ethical Issues in Translational Stem Cell Research
Abstract in UndeterminedTranslational stem cell research raises many interesting ethical questions, which have, to a greater or lesser degree, been debated at an international as well as at an interdisciplinary level. Nevertheless, there is still no international consensus regarding how a number of …
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Real-time membrane puncture detection using force sensors for micro-injections in phantoms
Micro-manipulators provide tools for researchers to improve workflow in common preclinical and clinical applications. Following drug delivery injections where drugs did not reach their target will squander research time, experimental animals and other resources. An ultrasound-guided robot developed …
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Multimodal imaging monitoring of key physiological changes of peripheral arterial disease
… studied, there is still a large gap between preclinical research and clinical translation. This is due in part to the lack of research standardization in preclinical studies, an inadequate resemblance of the animals’ model to the actual disease in humans, and the complexity of the disease’s …
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The contribution of disease focused nonprofits to biomedical research and development
… "valley of death" gap between basic and clinical research. Examples of such activities include developing preclinical research tools, supporting clinical trials infrastructure, and investing in private biotechnology companies. In this thesis, 1: 1) quantify the financial contribution of US-based …
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Evaluation of agonist pharmacotherapy for cocaine dependence: effects of continuous d-amphetamine treatment on cocaine self-administration in rats
… of both time and money. In view of this, recent research efforts have also been focused on investigating the utility of medications that are currently available for the treatment of other disorders. d-Amphetamine, an FDA-approved medication for the treatment of attention deficit hyperactivity …
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Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention
… needed to enhance the translational impact of preclinical research. The AAV-α-synuclein rat model is the only animal model to date that has been shown to robustly and consistently reproduce the primary neuropathological and behavioural features of PD. However, there has been little research on …
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DEVELOPMENTAL CONSEQUENCES OF GESTATIONAL CANNABIS EXPOSURE IN RAT ACROSS THE LIFESPAN
… of Cannabis consumption in Canada. However, preclinical research on gestational Cannabis exposure (GCE) primarily focuses on the effects of Δ9-Tetrahydrocannabinol (THC) through injection models, which fail to accurately reflect human usage patterns. This dissertation aimed to develop a more …
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Activatable photoacoustic contrast agents for sensing and delivering nitric oxide, and development of small molecule photoacoustic platforms with improved properties for in vivo imaging
… for high resolution imaging in small animals for preclinical research. As a result, in this document, I briefly discuss the principle of the photoacoustic effect and introduce the basics of photoacoustic tomography (Chapter 1). I then discuss our group’s work to develop near-infrared, ratiometric …
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On the origins of glioma: insights from brain network mapping
… in each field. In particular, I highlight preclinical research implying that gliomas originate from neural stem cells in the subventricular zone, as well as other work in mouse models demonstrating that gliomas infiltrate previously healthy brain networks. This thesis contributes three …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
… disease has allowed the use of these methods in preclinical research with the possibility to transfer directly the obtained results in clinic. In this thesis’s work we characterized two preclinical oncology models through the use of an animal PET instrument focusing on two processes correlated to …
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Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.
… inflammatory processes in AN, and results from preclinical research are few and largely inconsistent. In the first part of the thesis, we address this issue by measuring mRNA levels of several pro-inflammatory markers (TNF-α, IL-6, IL-1β and NLRP3) and molecules involved in oxidative stress …
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Tumour chemo sensitivity assays: an investigation into the susceptibility of cells to chemotherapeutics
… the analysis of larger numbers of compounds in preclinical research. This thesis has developed, and optimized a sensitive enzyme-release assay for monitoring natural cytotoxicity. It measures the release of the intracellular enzyme adenylate kinase into the culture supernatant after membrane …
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Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
… is decreased in depressed patients. Similarly, preclinical research has shown that repeated glucocorticoid administration significantly reduces reelin expression in the adult hippocampus. Combined, these results suggest that reelin may be an important protein to examine in regards to the …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… in various mood disorders such as depression. Preclinical and clinical data from studies in adults have shown that antidepressant drugs produce time-dependent changes in serotonergic and other systems and can also normalize dysfunction associated with the hypothalamic-pituitary-adrenal (HPA) …
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Monte Carlo simulations, in vitro and in vivo experimental verifications for preclinical studies
… are still needed. For translational cancer research, pre-clinical in vivo studies using small animals have become indispensable in bridging the gap between in vitro cell experiments and clinical implementation. When setting up such small animal experiments, various biological, technical and …
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Exploring the utility of the pig model for predicting bioavailability in humans
… there is considerable debate on which preclinical animal model is most appropriate for assessing oral bioavailability in humans. In order to streamline preclinical development, and reduce repeated testing in various animal models, it is necessary to get a better understanding which …
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NEW PHARMACOLOGICAL TOOLS FOR AUTISM RESEARCH: OXYTOCIN RECEPTOR MUTANT MICE AND ZEBRAFISH AS NEUROBEHAVIOURAL MODELS
… analogs with more suitable characteristics for preclinical research. To this end, a characterization of the behavioural phenotype of OTR knock-out mice (OTR-/-) and heterozygous littermates (OTR+/-) in comparison with their wild type counterparts (OTR+/+) has been carried out. General home cage …
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ZEBRAFISH (DANIO RERIO) AS A MODEL SYSTEM FOR THE FUNCTIONALVALIDATION OF CANDIDATE GENES FOR HUMAN DISEASES
… as a substitute, for other animal models in preclinical research. This PhD project aimed precisely at utilizing zebrafish to generate models of human diseases whose pathogenesis is currently poorly understood and for which effective treatments are not yet available. The main research line …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… candidate. The primary objectives of this research are to validate IFRA3Q1’s efficacy in reducing RA symptoms in preclinical models and to thoroughly evaluate its pharmacokinetic properties and safety profile. In Aim 1, we evaluated the therapeutic efficacy of IFRA3Q1 using the collagen …
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