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Showing 1 to 20 of 33 for “"Preclinical evaluation"”.
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Preclinical evaluation of novel calcium phosphate coated dental implants.
Contains fulltext : 82966.pdf (Publisher’s version ) (Open Access)
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PRECLINICAL EVALUATION OF A NOVEL NFIX INHIBITOR FOR MUSCULAR DYSTROPHIES TREATMENT
Le Distrofie Muscolari (DM) sono malattie eterogenee, caratterizzate da progressiva degenerazione muscolare che, nei casi più severi, causa dipendenza dalla sedia a rotelle e morte prematura per blocco respiratorio o disfunzione cardiaca. La migliore strategia terapeutica per le DM coinvolge …
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Preclinical Evaluation of 3D Printed Biomaterials for Repairing Critical-Size Bone Defects
… implantation in rats. <br>5- *In-vivo* evaluation of the biomaterials’ ability to support bone healing in a critical-size bone defect (15 mm rabbit’s radius segmental defect). Results and conclusion: Our results show that Ad-MSCs were capable of differentiating towards the osteogenic …
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Preclinical evaluation of a vaccine against IL-17 mediated inflammatory diseases including psoriasis
Psoriasis is a chronic autoimmune skin condition. Interleukin 17A (IL-17A) is a pro-inflammatory cytokine with a key role in the pathogenesis of this disease. Antibodies targeting IL-17A have shown superior efficacy compared with other psoriasis treatments, and long-term studies have demonstrated …
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Preclinical Evaluation of Immunomodulatory Effects of Aurora Kinase Inhibition In Human Papillomavirus Positive Cancers
… of alisertib, an Aurora Kinase A inhibitor using preclinical mouse tumor models of HPV+ cancers (mEER, TC-1, and C3.43). In vitro, alisertib treatment when compared to the vehicle control, reduced the level of phospho-Aurora Kinase A confirming the targeted activity. We observed morphological …
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Preclinical Evaluation of a Novel Polysaccharide Hydrogel for Local Chemotherapy Delivery to Solid Tumors
… clinical setting. This dissertation entails the preclinical evaluation of a novel polysaccharide hydrogel drug delivery system. The gel is designed to be injected intratumorally to deliver a chemotherapeutic agent, to protect a fragile chemotherapy agent from being degraded quickly in vivo, to …
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Preclinical evaluation of a novel telomerase inhibitor in malignant cells of the hematopoietic system
Telomerase represents an attractive target for a mechanism-based therapeutic approach because its activation has been associated with unlimited proliferation in most cancer cells. Recently, a non-nucleosidic small molecule inhibitor, BIBR1532, has been identified which is highly selective for the …
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Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
… of a rat model of neonatal HIE for use in the preclinical evaluation of infrared light therapy (IRL). Consistent with results from previous IRL efficacy studies using a rat model of adult global brain ischemia, IRL treatment attenuated cerebral injury resulting from hypoxia-ischemia in the …
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Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
… of this dissertation explore the development and preclinical evaluation of a radiolabeled antagonist peptide conjugate (RM2 = DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2) that targets the bombesin receptor (BB2r) overexpressed in human prostate cancer. Two …
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DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
… small chemical molecules, makes their preclinical evaluation particularly challenging. Consequently, there is an urgent need for innovative preclinical platforms capable of capturing their complex biological effects beyond conventional toxicity and efficacy endpoints. This PhD thesis is …
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Molecular Characterization of the Opioid Receptors: Design, Development, and Preclinical Evaluation of Salvinorin A-Based Molecular Probes.
… chemistry through the design, development, and preclinical evaluation of a series of C(22)-fused heteroaromatic salvinorin A analogues. Our in vitro models include: opioid receptor competitive radioligand binding affinity and functional [35S]GTP[γS] binding activity assays; while our in vivo …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
… in understanding the factors that influence preclinical performance. These gaps are particularly evident in in vitro and in silico studies, where the lack of predictive, MAP-specific translational models remains a major limitation. To address these limitations, this thesis aimed to enhance …
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Evaluation of allogeneic bone marrow-derived mesenchymal stem cells for use in equine joints: in vitro to preclinical evaluation
… BMDMSCs. Following in vitro studies, two preclinical, in vivo studies were performed. In the first study, allogeneic and autologous BMDMSCs were administered into clinically normal, contralateral, metacarpophalangeal joints. No difference was detected in the clinical or cytological …
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Preclinical Evaluation of Matrix Metalloproteinase Inhibitors and Protein Kinase C Activators in Cell and Mouse Models of Huntington’s Disease
<p>Huntington’s disease (HD) is an incurable genetic neurological disorder that affects 1 in 10,000 people, with no treatment that can alter the course of the disease. Neural cell death in the striatum and the cortex results from the accumulation of toxic mutant huntingtin protein (mHTT) fragments. …
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Preclinical evaluation of a novel AAV-GDF5 vector in a 6-OHDA model of Parkinson’s disease and evaluation of the effect of 6-OHDA on the expression of HDACs
Neurotrophic factors have shown promising results as potential disease-altering treatment methods for Parkinson’s disease (PD). However, there are many risks associated with surgically accessing such deeply located regions of the brain as the striatum or substantia nigra. Directly administered …
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Semi-synthesis, synthesis and preclinical evaluation of sigma receptors ligands for the treatment of neuropathic pain [Semi-sintesi, sintesi e valutazione preclinica dei ligandi dei recettori sigma per il trattamento del dolore neuropatico]
Il dolore neuropatico (NP) è una condizione cronica che colpisce il 7−10% della popolazione generale affetta da dolore cronico, un’alterazione dei segnali a livello del sistema nervoso periferico o centrale. La sua complessa fisiologia rende i trattamenti attuali inefficaci e spesso con di effetti …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
Whilst progress has been made in reducing mortality in some cancers, mortality rates remain high in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
Whilst progress has been made in reducing mortality in some cancers, mortality rates remain high in many cancers and there is a need to develop novel therapeutic strategies. In this thesis, various pharmacological strategies designed to enhance the activity of existing therapeutic drugs were …
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Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
… better systems are required to determine in vivo preclinical efficiency and drug-target interactions. Engineering of cancer cells to express fluorescent or bioluminescent proteins, either endogenously or under the control of specific gene promoters, and their detection by noninvasive optical …
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