Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Preclinical development"”.
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Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
… and IBC molecular understanding prevents the development of effective therapeutic strategies. To identify effective treatments, we explored aberrant apoptosis pathways and cell membrane fluidity as novel therapeutic targets.</p> <p>We first identified an effective therapeutic strategy against …
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Physiologically-Based Pharmacokinetic (PBPK) Modeling for the Preclinical Development of Spectinamide Antibiotics
… are lead spectinamide compounds currently under preclinical development for the treatment of MDR and XDR tuberculosis. These compounds have previously been tested at various combinations of dose level, dosing frequency, and routes of administration in mouse models of Mtb infection and in healthy …
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Dual mTOR/HDAC Inhibition: Preclinical Development of a Novel Breast Cancer Therapy
… cell lines warrants further study and clinical development of this promising breast cancer treatment strategy.</p>
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
Chronic pancreatitis (CP) is an irreversible disease process defined by acinar cell necrosis, inflammation and fibrosis. With disease progression, patients develop pancreatic insufficiency secondary to the destruction of functional pancreatic tissue and its replacement with scarring. Patients with …
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Advancing the Preclinical Development of Secondary Metabolites from Cacospongia mycofijiensis for the Treatment of Cancer
… in a paucity of studies aimed at advancing the preclinical development of these secondary metabolites from <em>C. mycofijiensis </em>for the treatment of two cancers in need of additional effective therapeutics.<em> </em></p> <p>The three lead chemotypes derived from <em>C. mycofijiensis …
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PRECLINICAL DEVELOPMENT OF CARBON NANOTUBE MEDIATED THERMAL THERAPY FOR TREATMENT OF GLIOBLASTOMA MULTIFORME: DETERMINING THE EFFECTS OF NANOMATERIAL PROPERTIES, DOSE, AND IRRADIATION PARAMETERS ON THE EFFICACY AND POTENTIAL NEGATIVE REPERCUSSIONS OF TREATMENT
… Thermal Therapy (CNMTT), is dependent upon the development of carbon nanotubes that can effectively be delivered throughout the tumor site while still maintaining the ability to generate heat upon exposure to laser energy. Additionally, the CNTs used in this therapy must be minimally toxic to …
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NOVEL STRATEGIES FOR IMPROVING THE PHARMACOLOGICAL PROPERTIES OF PLATINUM-ACRIDINE ANTICANCER AGENTS
… low-nanomolar concentrations. Unfortunately, the preclinical development of these agents has been hampered by their severe systemic toxicity. The goal of this dissertation was to devise strategies that improve the drug-like properties of platinum-acridines and allow their safe delivery. To achieve …
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Financing the "Valley of Death" : an evaluation of incentive schemes for global health businesses
… gap when trying to develop a new drug from preclinical development to a proof of concept clinical trial. This funding gap is sometimes referred to as the "valley of death", a reflection of the vast number of companies that are unable to raise the needed capital to progress into the clinic. …
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SYNTHETIC AND MECHANISTIC STUDIES OF PRECIOUS METAL-MODIFIED TYROSINE KINASE INHIBITORS
… MS), the compound was too reactive for further preclinical development.
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Pre-clinical development of cyclodextrin-based nanoparticles for oral delivery of protein/peptide drugs-in vitro and in vivo evaluation
… named as liraglutide. In the first stage of the preclinical development of these formulations, the fabrication process of the three prototypes containing the different cargos was optimized. The resulting formulations showed suitable physico-chemical properties for an oral administration as well …
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The Role of RUVBL1/RUVBL2 and Their Potential as Therapeutic Targets in Non-Small Cell Lung Cancer
… make RUVBL1/2 an attractive target for future preclinical development as a radiosensitizer in NSCLC.
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Cellular And Mechano-Active Material Approaches To Improve Disc Repair After Herniation
… herniation. This highlights the need for the development of disc repair strategies that improve healing and prevent recurrent herniation. To that end, the main objectives of this work were to develop cellular, molecular, and structural augmentation strategies for the repair of disc …
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Exploring the utility of the pig model for predicting bioavailability in humans
… that there is a need to reduce costly drug development delays and facilitate earlier access to market for new medicines. Within drug development, there is considerable debate on which preclinical animal model is most appropriate for assessing oral bioavailability in humans. In order to …
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Design and development of novel antagonists targeting Cdc20, a central regulator of the Anaphase-Promoting Complex/Cyclosome, for the treatment of cancer
… Cdc20 a promising therapeutic target for the development of innovating cancer therapy strategies. Although numerous small compounds that supress Cdc20 expression have been reported in the literature, none are clinically approved and in addition, many are not truly Cdc20-specific. Thus, …
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Heterologous overexpression, purification, and characteristion of the Plasmodium falciparum vacuolar iron transporter, PfVIT
… resistances arising in the parasite and by the development of mosquitoes that are resistant to pesticides.<br/><br/>Despite more than 20 candidate vaccine constructs are undergoing preclinical development and first trials, a vaccination program is still not available. The scientific community is …
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A Novel Interleukin-15 Receptor Antagonist for the Treatment of Rheumatoid Arthritis
… IFRA3Q1’s efficacy in reducing RA symptoms in preclinical models and to thoroughly evaluate its pharmacokinetic properties and safety profile. In Aim 1, we evaluated the therapeutic efficacy of IFRA3Q1 using the collagen antibody-induced arthritis (CAIA) model in BALB/c mice. Mice are treated …
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Developing tissue engineered models of oral mucosa and oral cancer to study novel therapeutic and diagnostic techniques.
… models to tackle some of the key issues in the preclinical development of novel diagnostic technologies for oral cancer and oral dysplastic lesions.
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… As a result, there is a pressing need for the development of novel and effective cancer treatment. The work presented here focuses on the identification of new anticancer agents by targeting three important cancer targets: survivin, MDM2, and tubulin. Survivin, a member of the inhibitor of …
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PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy
… between Mtb and the immune system leads to development of diverse environmental niches and physiology within the lung of the TB patients. Mtb is thought to adapt and thrive in such an environment by transforming to different phenotypic variants. Such variants are difficult to kill and are …
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