Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 158 for “"Precision medicine"”.
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Statistical foundations for precision medicine
… pathophysiology. The growing concept of "precision medicine" addresses this challenge by recognizing the vast yet fractured state of biomedical data, and calls for a patient-centered view of data in which molecular, clinical, and environmental measurements are stored in large shareable …
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Unlocking precision medicine using DNA nanotechnology
… healthcare systems have begun the transition to ‘precision medicine’, where patients are provided with personalized treatments selected for maximum efficacy against their unique biomarker profile. However, precision medicine can only be achieved if the methods for detecting and quantifying …
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Leveraging knowledge networks for precision medicine
… data hold the great promising of making precision medicine a reality. However, integrating and mining these large-scale, heterogeneous, and noisy dataset pose several fundamental computational challenges and have therefore become a bottleneck to clinical decision making and medical …
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Systems Immunology Approaches for Precision Medicine
… critical foundational pieces in the framework of precision medicine initiatives that can assist in the diagnosis, understanding, and treatment of disease.
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Deep Learning for Enhancing Precision Medicine
… but not for others. It necessitates the need for precision medicine that tailors medical treatment to individual patients. Omics data holds comprehensive genetic information on individual variability at the molecular level and hence the potential to be translated into personalized therapy. …
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Precision Medicine in Immunotherapy and Lung Cancer
… techniques and methods to advance the goal of precision therapy in clinical oncology, encompassing tumour-specific and treatment-specific methods. It explores tumour-specific treatment such as platinum chemotherapy or immunotherapy for non-small cell lung cancer, and combines potential …
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Precision Medicine in Diabetes Using Continuous Glucose Monitoring
… methods in machine learning can enable precision medicine in diabetes by leveraging wearable CGM data for improved disease management.
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From diagnosis to therapy: algorithmic methodologies for precision medicine
… it has become established the idea of a novel medicine where a patient is the center around which multidisciplinary teams (made up of physicians, statisticians and bioinformaticians) sew targeted treatments. Precision medicine involves the use of detailed patient-specific molecular information …
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Towards fine-grained automated age extraction for precision medicine
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
Major Depressive Disorder (MDD) is a clinically heterogeneous disorder with substantial interindividual variability in antidepressant treatment response and tolerability. Genetic variation, particularly in pharmacokinetic genes such as CYP2C19 (drug metabolizing enzyme) and ABCB1 (encoding the …
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High-dimensional machine learning for drug target discovery and precision medicine
Identifying mechanisms of complex diseases such as Alzheimer’s disease or cancer is essential to discover molecular targets for therapeutic intervention, ideally in a personalized manner. Gene expression measured in a tissue sample is an informative proxy to the protein levels in that tissue and …
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Quantitative Imaging For Precision Medicine In Head and Neck Cancer Patients
<p>The purpose of this work was to determine if prediction models using quantitative imaging measures in head and neck squamous cell carcinoma (HNSCC) patients could be improved when noise due to imaging was reduced. This was investigated separately for salivary gland function using dynamic …
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Organizational Antecedents to the Implementation of Precision Medicine: Overcoming Resistance to Change
Precision medicine (PM) is “the treatment and prevention of disease that takes into account individual variability in genes, environment, and lifestyle for each person” (NIH, 2015). PM was poised to transform clinical practice in 2003 when the Human Genome Project reached completion but resistance …
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Efficient Intelligence Towards Real-Time Precision Medicine With Systematic Pruning and Quantization
The widespread adoption of Convolutional Neural Networks (CNNs) in real-world applications, particularly on resource-constrained devices, is hindered by their computational complexity and memory requirements. This research investigates the application of pruning and quantization techniques to …
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Precision Medicine Approach to Improving Reconstructive Surgery Outcomes for Breast Cancer Survivors
As the survival rate increases, the importance of quality of life post-cancer is increasing. This, in conjunction with genetic screening, has increase the number of breast reconstructions 36%. The most common complication causing revision of reconstructive surgery is the formation of a dense scar …
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Computational imaging and multiomic biomarkers for precision medicine: characterizing heterogeneity in lung cancer.
… by personalized biomarkers is needed to develop precision medicine treatment strategies for cancer. Large-scale genome-based characterization poses the disadvantages of high cost and technical complexity. Further, a histopathological sample from a tumor biopsy may not be able to fully represent …
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Advancing Technologies for Precision Medicine: From Liquid Biopsy to Single-Molecule DNA Sequencing
Precision oncology depends on technologies capable of identifying tumor-associated mutations and monitoring how they evolve during therapy using minimally invasive samples. This dissertation integrates blood-based liquid biopsy assays with an emerging single-molecule nanopore sequencing platform to …
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Precision Medicine and It's Ethical and Social Implications: Public Health and Gobal Persepctives
<p>Ever since President Obama's launch of the Precision Medicine Initiative (PMI) in 2015, precision medicine (PM) has been anticipated as the new paradigm for healthcare with the capacity to “empower patients, researchers, and providers to work together toward the development of individualized …
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Development of chemical tools for biomarker detection and targeted therapeutics for precision medicine
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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From structural dynamics to drug repurposing: computational approaches in the context of precision medicine
Precision medicine represents a paradigm shift in therapeutic strategy, moving away from "one-size-fits-all" treatments toward approaches tailored to the unique characteristics of the patient. The success of this transition depends on the avail- ability of drugs acting on a wide variety of targets …
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