Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Preadipocyte"”.
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Optimierung der Proliferation und Differenzierung humaner Präadipozyten durch den Einsatz von humanem Serum
… solution is adipose tissue engineering with preadipocytes. These adipogenic precursor cells have the ability to proliferate and differentiate into adipose tissue after transplantation. This study aimed at developing an optimal protocol for proliferation and differentiation of preadipocytes. …
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Identification of ITGBL1: A Novel Regulator of Adipogenesis
… are formed from their progenitor cells (the preadipocyte) when the body has a need to store excess lipid. It has been shown that the pathological expansion of white adipose tissue (WAT) leads to insulin resistance and cardiovascular disease. In spite of this clear observation, the mechanisms …
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Cellular and Molecular Mechanisms Governing Intramuscular Fat Development and Growth in Cattle
… stage of adipose progenitor cells, and origin of preadipocytes. In addition, I tested the hypothesis that the delayed development and slower growth of IMF is in part due to inhibition by signaling proteins secreted by the surrounding muscle tissue. I conducted four studies. In the first study, I …
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Role of appetite-regulating peptides in adipose physiology in broiler chicks
… was thus to evaluate effects of NPY on chick preadipocyte proliferation and differentiation. Preadipocytes were treated with NPY and gene expression and cellular proliferation were evaluated. Cells were also treated with NPY during differentiation and harvested during the later stages. With …
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Modulating adipogenesis via signaling pathways and cellular redox state
… cell physiology of human progenitor fat cells (preadipocytes). NO significantly promoted the differentiation process from immature fat cells to mature adipocytes. The proliferation of preadipocytes, however, was inhibited. The results of this thesis are especially helpful in the context of soft …
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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… including activins, which regulate critical preadipocyte and mature adipocyte functions. Previous studies have demonstrated that Smad2 global knockout mice exhibit embryonic lethality, whereas global loss of Smad3 protects mice against diet-induced obesity and the direct contributions of …
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Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… by immunocytochemistry and compared to human preadipocytes sourced commercially. The secretion of FGF, adiponectin and VEGF by the preadipocyte and the SVF mesenchymal cells was compared and the ability of their secretome to modulate dermal fibroblast proliferation, metabolism and migration …
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Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… by immunocytochemistry and compared to human preadipocytes sourced commercially. The secretion of FGF, adiponectin and VEGF by the preadipocyte and the SVF mesenchymal cells was compared and the ability of their secretome to modulate dermal fibroblast proliferation, metabolism and migration …
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Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
… conjunctival fibroblast) and orbital (orbital preadipocyte) cells. The data therefore emphasises the putative role of 11β-HSDs in the ocular and orbital microenvronment.
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The Identification of the MCHR-1 in J774A.1 Macrophages and The Effect of Melanin-concentrating Hormone on a 3T3-L1 Adipocyte-J774A.1 Macrophage Co-Culture
… that MCH signaling by developing 3T3-L1 preadipocytes elicits changes in gene expression of several immune regulatory genes (Cook, 2021). I hypothesize that signaling between immune cells and adipose tissue contributes to the negative health outcomes of the obese phenotype. Co-culturing …
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Increased fat oxidation in 3T3-L1 adipocytes through forced expression of UCP 1
… pRevTRE and was stably transfected into 3T3-L1 preadipocytes prior to differentiating them into adipocytes. A reporter gene (EGFP) was also transfected in parallel to optimize the transfection and preadipocyte differentiation conditions as well as to demonstrate regulated expression. Metabolite …
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
… the stage of terminal differentiation. In 3T3-L1 preadipocyte cell line, addition of recombinant murine sonic Hh (Shh) potently inhibited adipogenic differentiation dose-dependently, resulting in decreased intracellular triglyceride accumulation and reduced mRNA levels of established adipogenic …
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The impact of whey protein isolate on energy balance regulation
… LPA5 is a novel candidate in regulating of preadipocyte growth and differentiation, and may mediate dietary protein effects on adipose tissue.
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Assessment of blue whiting protein hydrolysate bioactivities using cell culture models
… w/v dw) reduced triglyceride accumulation during preadipocyte differentiation (p<0.05), however none of the hydrolysates hydrolysed triglycerides in fully mature adipocytes. Interestingly, after SGID, all hydrolysates reduced triglyceride accumulation during differentiation and all except one …
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The role of Ad-36 and its E4orf-1 protein in modulating glycemic control
… are modulated by Ad36. In vitro, Ad36 increased preadipocyte differentiation, de-novo lipogenesis, and fat oxidation. Ad36 increased the proportion of small adipocytes in mice on a chow diet, whereas in HF-fed mice, Ad36 increased the proportion of large adipocytes. Adipose tissue macrophage …
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Bioexploration of wild Alaskan berries: From field screening to functional food
… and obesity. R. spectabilis samples increased preadipocyte-factor-1 levels by 82% over control, and proanthocyanidin-rich fractions from multiple species reduced lipid accumulation in 3T3-L1 adipocytes. Furthermore, extracts of V. uliginosum and E. nigrum (Point Hope) reduced serum glucose …
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Präadipozyten auf neuartigen Textilmatrizes
… possibilities, adipose tissue engineering with preadipocytes offers new perspectives. Essential requirements for successful reconstruction are: adequate threedimensional construct, autologous cells, ideal cultivation conditions and sufficient vascularization for further in vivo experiments. This …
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A Human Pluripotent Stem Cell-Derived Model for the Investigation of Thermogenic Adipocyte Development and Function
… mice affects the differentiation of murine brown preadipocytes. I show that contrary to hPSCs, 3D culture did not improve murine brown preadipocyte differentiation, although a functional improvement was observed. Compared to lean ECM, obese ECM impaired BA differentiation and function.
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Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
… in insulin-responsive cell types, 3T3-L1 preadipocyte models with conditional overexpression of p85$\alpha$ Y657X or p85$\alpha$ R649W were generated. Doxycycline-induced overexpression of mutant p85$\alpha$ attenuated insulin-stimulated Akt phosphorylation due to reduced …
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