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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 28 for “"Pre-malignant"”.

  1. Effects of low linolenic soy oil on pre-malignant human mammary epithelial cell progression

    McCall, Elaine TeresaVirginia Tech2008

    … old, ovariectomized, athymic mice received human pre-malignant breast cells (MCF-10AT1 1 x 105 cells/40μl/ Matrigel/spot, 4 spots/mouse). Mice were divided into three groups and then fed isocaloric and isonitrogenous diets with disparate fat sources: LLSO (20% of total energy intake), SO (20%) and …

    vt Repository record

  2. Endometrial Cancer and Pre-Malignant Conditions in Young Women: Survey of Endometrial Sampling Practices by Canadian Gynecologists

    Palerme, Stephanie2010

    … of respondents have had young patients with malignant or pre-malignant endometrial conditions. Physicians ≤ 39 years have had less experience with these patients (59.6%, p=0.002) as have physicians practicing in communities without ob/gyn residents (35.2%, p=0.006). Sampling method was …

    queens Repository record

  3. Genetic changes in the development of multiple myeloma

    Chiecchio, LauraUniversity of Southampton2010

    … genetic point of view, specific abnormalities represent initiating events (i.e. IgH translocations or hyperdiploidy) of this multistep process while others occur at later stages. In this study, interphase-FISH showed that initiating events are present in MGUS (n=187) and asymptomatic MM (SMM, …

    soton Repository record

  4. Ultrahigh resolution optical coherence tomography for the detection of early stage neoplastic pathologies

    Hsiung, Pei-Lin, 1975-Massachusetts Institute of Technology2005

    … Diagnostic modalities capable of identifying pre-malignant tissue at an early stage could therefore significantly improve treatment outcome. Optical coherence tomography (OCT) is an emerging biomedical imaging technique that can potentially be used as an in vivo tool for identifying early …

    mit Repository record

  5. Genetic analyses, protein expression, type and function with clinical and immunological correlates in human papillomavirus associated head and neck neoplasia

    Masterson, LiamUniversity of Cambridge2018

    … gene. As most patients with HPV associated OPSCC present at an advanced stage, the detection and genetic analysis of a pre-malignant state would be important as it infers the potential for a screening test (similar to the uterine cervix model). To investigate this, whole transcriptome analysis …

    cambridge Repository record

  6. Advances in Optical Coherence Tomography and Microscopy for endoscopic applications and functional neuroimaging

    Aguirre, Aaron Dominic, 1977-Massachusetts Institute of Technology2008

    … the need to remove and process specimens. Previous studies have suggested that OCT holds great potential for use in laparoscopic and endoscopic applications to detect early stage neoplastic pathologies. A minimally invasive imaging modality capable of identifying pre-malignant tissues in …

    mit Repository record

  7. The impact of positive margins and crypt involvement in excisional procedures of the cervix on recurrence rates of premalignant diseases of the cervix

    Addae, HaleemaDepartment of Obstetrics and Gynaecology2021

    … involvement increased the rate of recurrence of premalignant disease in patients who had excisional procedures. METHODS In this retrospective review of the colposcopy database, patient records and pathology database, women who had cervical excisional procedures at the Groote Schuur Hospital …

    cape-town Repository record

  8. CHARACTERIZATION OF GENETIC AND EPIGENETIC MODIFICATIONS IN A MODEL OF INFLAMMATION-DRIVEN CANCER

    COLLINO, AGNESEUniversità degli Studi di Milano2014

    … specifically in hepatocytes starting from the pre-malignant, chronic inflammatory step. This inflammatory signature is retained up to the more advanced HCC stage, and is accompanied by the activation of members of the AP1 transcription factor family. In parallel, by whole exome sequencing, we …

    milano Repository record

  9. Photodynamic Therapy utilizing Interstitial Light Delivery Combined with Spectroscopic Methods

    Soto Thompson, MarceloAtomic Physics, Department of Physics, Lund University2004

    … impaired for a longer period of time. The work presented aims at developing equipment and methods that use light for both detection and treatment of various malignant or pre-malignant conditions. Fundamental knowledge on the interaction between light and tissue is required in order to develop …

    lund Repository record

  10. Metabolomic Biomarkers for Colorectal Cancer

    Farshidfar, FarshadGraduate Studies2016

    … the serum metabolome that appear as a result of malignant and pre-malignant lesions in the colon and rectum. In Chapter 2, Application of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy for staging CRC is described. Chapter 3 describes a larger study …

    calgary Repository record

  11. The pre-clinical evolution of haematological malignancies

    Collord, GraceUniversity of Cambridge2019

    … tissues. However, the factors governing whether pre-cancerous cells transform into cancer are poorly understood, hindering identification of clones that are clinically significant rather than benign sequelae of ageing. The main aim of this dissertation has been to explore this process in the …

    cambridge Repository record

  12. Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery

    Saeed, SidraUniversity of Bradford2021

    … Due to late detection, patients often present with oral pre-malignant lesions which have progressed to an advanced stage of HNSCC. In this study, the samples were from a male cohort as generally, men are at two to four-fold higher risk than women with over 90% of HNSCCs arising in the …

    bradford Repository record

  13. Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery

    Saeed, SidraUniversity of Bradford2021

    … Due to late detection, patients often present with oral pre-malignant lesions which have progressed to an advanced stage of HNSCC. In this study, the samples were from a male cohort as generally, men are at two to four-fold higher risk than women with over 90% of HNSCCs arising in the …

    bradford Repository record

  14. PI3Kδ in B cell Homeostasis and Transformation

    Baeck, JuliusUniversity of Cambridge2024

    … PI3Kδ in B cell homeostasis, maintenance, and malignant transformation. The Okkenhaug lab has previously identified a novel mouse model for Diffuse Large B Cell Lymphoma which is driven by the cooperation of hyperactive PI3Kδ with B Cell Lymphoma 6 (BCL6), a master regulator of the Germinal …

    cambridge Repository record

  15. Mutant Kras Alters Extracellular Vesicle Microrna Sorting In Pancreatic Cystic Neoplasms

    Dittmar, Rachel L, <p>https://orcid.org/0000-0002-0567-2450</p>2023

    … biomarkers to detect early stage PDAC or its precursor lesions in a timely manner for effective surgical intervention. When potential PDAC precursor lesions, such as mucinous pancreatic cysts are found, there are no reliable molecular markers to determine which of these lesions will become to …

    uthsc Repository record

  16. Repression of telomerase components in isogenic normal, immortal and tumorigenic cells

    Maritz, MichelleUNSW, Sydney2014

    … The functional and molecular consequences of repressing the telomerase components hTERT, hTR and dyskerin were compared in isogenic normal, immortal (pre-malignant) and tumorigenic human foetal lung (MRC5) myofibroblasts, as well as a fibrosarcoma derived cell line, Ht1080. siRNA-mediated …

    unsw Repository record

  17. Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment

    Tulkki, Valtteri Heikki JuhaniUniversity of Cambridge2018

    Cervical cancer still represents the fourth most common cause of cancer deaths in women worldwide. Human papilloma virus (HPV) infection plays a role in cervical carcinoma initiation, but other genomic changes are needed for pre-malignant abnormalities to fully develop to cancer. This often happens …

    cambridge Repository record

  18. Fluorescence endoscopic imaging system for detection of colonic adenomas

    Wang, Thomas D. (Thomas Duen-Shyr)Massachusetts Institute of Technology1996

    … differences between normal and pre-malignant tissue. It is desired to extend this method to wide area surveillance using endoscopically-collected fluorescence images. Methods: An analytic model was developed to determine the number of photons collected endoscopically in terms of …

    mit Repository record

  19. Biomarkers of Progression from Barrett's Oesophagus to Oesophageal Adenocarcinoma

    Alastal , Hani2019

    Barrett’s oesophagus (BO) is a pre-malignant condition for oesophageal adenocarcinoma (OAC) [1], the incidence rate of which has been rising dramatically over the last four decades in the western world [2, 3]. Survival of an OAC affliction is poor, and one of the ways to improve this would be by …

    southwales Repository record

  20. Immunogenetic analysis of HLA Class II in premalignant disease of the cervix and correlation with HPV status

    Odunsi, Adekunle OmatayoThe Open University1999

    … neoplasia (CIN) and cervical cancer. However, pre-malignant or malignant transformation is not always observed with HPY infection. lILA molecules are important in the regulation of the immune response to foreign antigens. The role of genetic variation at the HLA class II loci (DR and DQ) in CIN …

    the-open-u Repository record

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