Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 363 for “"Pre-clinical"”.
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Pre-clinical Targets for Ischemic Brain Injury
… in ischemic injuries but is generally underappreciated. Research has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury to oligodendrocytes, resulting in demyelination. Glutamate receptor antagonists have been trialled in stroke patients but …
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The pre-clinical evolution of haematological malignancies
… tissues. However, the factors governing whether pre-cancerous cells transform into cancer are poorly understood, hindering identification of clones that are clinically significant rather than benign sequelae of ageing. The main aim of this dissertation has been to explore this process in the …
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PRE-CLINICAL MODELING OF CELL AND GENE THERAPY OF FANCONI ANEMIA
… distribution. This method enables the comprehensive assessment of active HSPCs across the dynamic range in mice. Applying this method to a FA mouse model, Fancc-/- mice, I revealed that these mice maintain normal levels of precursor cells despite repopulation defects post-transplantation. …
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Magnetic Resonance Imaging of prostate cancer. Assessment of aggressiveness and pre- clinical developments
Contains fulltext : 150175.pdf (Publisher’s version ) (Open Access)
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Pre-clinical evaluation of inhibitors of apoptosis protein (IAP) antagonists in colorectal cancer
… advanced CRC. Consequently, there is an unmet clinical need for novel therapeutic agents for treating patients with CRC in the advanced disease setting. <br/><br/>CRC is frequently associated with a pro-inflammatory tumour microenvironment in which TNFα signalling plays an important role. …
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Pre-clinical assessment of novel candidate HIV-1 vaccines using the Chacma baboon
Includes bibliographical references (leaves 176-221).
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Pre-Clinical Development Of Aav Mediated Gene Therapy For Familial Lecithin Cholesterol Acyltransferase Deficiency
… KO/ human ApoA-I transgenic mice using AAV8 expressing human LCAT. AAV8-TBG-hLCAT induces significant increases in plasma % cholesterol esterified at a dose as low as 3e9 GC per mouse, which is approximately equivalent to 1.5e11 GC per kg. We also characterize the first gain-of-function variant …
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Development and Characterization of Pre-Clinical Epilepsy Models to Evaluate Potential Anti-Seizure Targets.
Epilepsy is the oldest known neurological disorder in humans and has been extensively studied for decades. Nevertheless ~30% epilepsy patients remain refractory to pharmacological intervention today. Limitations of animal models that are used in anti-epileptic drug screening, and a lack of novel …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… as compared to that of the DES co-solvent preparation. Also, the in vitro release of DES was inversely dependent on the particle size of the nanosuspensions. The pharmacokinetic studies in the Sprague Dawley rats demonstrated that as compared to the oral DES suspension and subcutaneous …
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Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa
… neurodegenerative disease. Patients with RP present with the loss of their peripheral visual field, and the disease will progress until there is a full loss of vision. Approximately 36,000 cases of simplex and familial RP worldwide are caused by a mutation in the rod-specific cyclic guanosine …
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A Pre-Clinical Assessment of Minocycline For Treatment of Chronic Neuropathic Pain After Spinal Cord Injury
… neuropathic pain (CNP). Unfortunately, the clinically approved, current standard of treatment, gabapentin, only provides temporary pain relief. This treatment can cause numerous adverse side effects that negatively affect the daily lives of SCI patients. There is a great need for …
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Development of musculoskeletal models for the design and the pre-clinical validation of hip resurfacing prosthesis
… competitive products can be achieved only by predicting the possible scenario of failure, to date the understanding of the implant quality is poorly pre-clinically addressed. Thus revision is the only delayed and reliable end point for assessment. The aim of the present work was to model the …
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Novel combination strategies with Aurora Kinase Inhibitors: using pre-clinical data to guide clinical trial design
… drugs with aurora kinase inhibitors (AKI) in pre-clinical models and then to design a clinical trial to assess these in patients with bladder cancer. Particular interest was stimulated by the correlation between over-expression of aurora kinases (AKs) with aggressive clinical behaviour in many …
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CHARACTERIZATION AND EVALUATION OF CLINICALLY RELEVANT READOUTS IN A PRE-CLINICAL MODEL OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
… (Tashiro et al. 2017), there is no consensus on preclinical tests best used to investigate IPF mainly due to some limitation that need to be considered when extrapolating findings from animal model to the human disease (Carrington et al. 2018). In fact one of the most challenging aspects of drug …
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Enhanced pre-clinical assessment of total knee replacement using computational modelling with experimental corroboration & probabilistic applications
… greater efforts are being invested into the pre-clinical analysis of TKR designs, to improve their performance in-vivo. A wide range of experimental and computational methods are used to analyse TKR performance pre-clinically. However, direct validation of these methods and models is …
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Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration
… goal to treat patients with IVD herniations and prevent further degeneration. To bring tissue-engineered repair strategies to the clinic, it is imperative to understand what has already been investigated, what biomaterials and strategies are successful, and what challenges remain (Chapter 1). …
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Drosophila melanogaster Genetic Model of Parkinson’s Disease: phytotherapy approach for a new and more sustainable pre-clinical investigation
… LRRK2WD40 (deletion of WD40 domain), that both express essential phenotypic characteristics of PD in humans, albeit with a different biochemical mechanism and pathways. Since therapeutic treatments to limit the onset of PD are not yet available and the common approach to treating patients is to …
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