Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 147 for “"Pre-B"tzinger complex"”.
-
Mechanism for Pre-B Cell Loss in Mutant Ali/Ali Rabbits
<p>Pre-B cell receptor (pre-BCR) signaling is a critical checkpoint in B cell development in which B-lineage cells expressing functional μ-chains undergo selective expansion. My dissertation work used a rabbit model system to study how VH structure affects the early stages of B cell development in …
-
Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction
B cells exert antigen presenting functions at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest in the case of acute graft-versus-host …
-
Characterization of neural ion regulation dysfunction during insult and evaluation of micro-opioid receptor activation during simulated ischemia in the pre-botzinger complex
The health and vitality of brain tissue is dependent upon the cells' abilities to maintain ionic homeostasis across their plasma membranes. Even slight alterations in intracellular or extracellular can have a devastating effect on excitability and neural vitality. This thesis investigates several …
-
A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line
… have been identified, but the complex processes underlying fine control of IL-7R[alpha][alpha] expression are poorly understood. The RNAi Consortium's lentivirus-based shRNA library targeting murine kinases and phosphatases has allowed large scale screening for modulators of …
-
The Dual Role of OCA-B in B Cell Development and Signaling
… that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream octamer element with the consensus sequence 5'-ATGCAAAT-3' in target gene promoters and enhancers. At the octamer element, the OCT-1/2-OCA-B complex is able …
-
Structure determination of a yeast ribosomal protein L30 and pre-mRNA binding site complex by NMR spectroscopy
… ribosomal protein L30 and its auto-regulatory pre-mRNA binding site provide one of the best examples the critical role of protein-RNA interactions in regulation of RNA processing and control of gene translation. A model system for this interaction, which includes the ribosomal L30 protein and …
-
The hepatitis B core promoter: Control of viral life cycle events
The HBV core promoter transcribes both the pre-core and the pre-genomic mRNAfrom which translation of the HBeAg and HBcAg occurs respectively..This study aimed to investigate the importance of the CP in viral replication. Pairedsamples, pre- and post HBeAg seroconversion, were selected from 14 …
-
Pre-transmetalation intermediates in the Suzuki-Miyaura reaction revealed: the missing link
… popularity of the Suzuki-Miyaura reaction, the precise manner in which the organic fragment is transferred from boron to palladium has remained elusive for over 30 years. The work described in this dissertation has focused on identifying such species by low temperature rapid injection NMR …
-
An investigation of beginning teachers’ journeys through complex landscapes of practice
… beginning teachers undergo during their pre-service year and their first year of teaching. Such an investigation is timely in the light of fundamental government reforms of current government policy that promotes a model of Initial Teacher Education (ITE) that is located in schools rather …
-
Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
SLP-65 is an adaptor protein preferentially expressed in B cells with a central role in BCR and pre-BCR mediated signal transduction. By providing multiple binding sites for other cellular effector molecules it assembles various proteins into one signaling complex. Therefore SLP-65 is involved in …
-
An exploratory study of the factors that influence pre-service teachers' instructional practices with diverse students.
The purpose of this study was to examine the complex array of factors in teacher education programs that influence pre-service teachers' instructional practices with diverse students. Participants in the study included eight female 2008 graduates of a teacher education program at a private …
-
EVOLUTION OF THE EASTERN ALPS FROM THE PALEOZOIC ONWARD: CONSTRAINTS AND INSIGHTS FROM THE (ULTRA)BASIC ECLOGITIC COMPLEX OF MILCHENKAR ÖTZTAL-STUBAI COMPLEX (EASTERN ALPS, TYROL, AUSTRIA)
The Ötztal-Stubai Complex (OSC) is one of the widest tectonic units of the Alps, belonging to the Eastern Austroalpine domain and extending between the Engadine and Tauern windows, the Northern Calcareous Alps and the Vinschgau/Venosta valley. Together with other polycyclic crystalline basements …
-
Biosystematics of the annual species of the Mimulus guttatus species complex in British Columbia, Canada
The M. guttatus species complex consists of several morphologically and ecologically distinct taxa, which, for the most part, are able to intercross; this makes it both an evolutionarily fascinating group to study and a taxonomic nightmare. In this study I found that on one ecologically diverse …
-
The experience of mothers practising kangaroo mother care in the East London hospital complex
… and morbidity due to low birth weight and pre-term birth are high, especially in developing countries where resources and qualified neonatal staff are scarce. There is a need to find measures that reduce the cost of care for low birth weight and pre-term babies without sacrificing quality. …
-
Isolation and Characterization of Human Precatalytic Spliceosomal B Complexes
Die katalytische Aktivierung des spleißosomalen B Komplexes ist eine mechanistische Voraussetzung für den Vorgang des Prä-mRNA Spleißens. Bisherige Untersuchungen dieses Komplexes wurden in Anwesenheit von Heparin durchgeführt, wodurch weniger stabil assoziierte Faktoren bei der Komplexisolierung …
-
Part I: synthesis and cross-coupling of the C1-C12 primary organoborane building block of amphotericin B; Part II: site- and stereoretentive cross-coupling of unactivated secondary boronic acids inspired by amphotericin B
… flexibly assembled in a systematic fashion from pre-fabricated building blocks, the synthesis of small molecules has remained a relatively slow, complex, and unsystematized process. With the potential of addressing these limitations, an analogous building block-based approach for making small …
-
Amphotericin B ion channels restore cystic fibrosis airway surface physiology
… We demonstrate here that AmB actually predominantly forms large, extramembranous aggregates that kill yeast by extracting ergosterol (Erg), a required sterol in yeast membranes. Additionally, AmB is toxic to cells only when the ratio of AmB present exceeds that of membrane sterols. …
-
Structural studies in a Proterozoic gneiss complex and adjacent cover rocks, west Needle Mountains, Colorado
… rocks away from the basement supports the interpretation of this contact as an unconformity at the base of the Uncompahgre Group. Alteration of the basement rocks along this contact involved hydration and the loss of CaO, MgO, SiO₂, and Na₂O. The phyllite zone is interpreted as a metamorphosed …
-
Determinants of left ventricular mass as measured by Doppler echocardiography in pre-adolescents
… to determine sexual maturation. Carotid Pulse pressure was assessed by applanation tomometry in the left carotid artery. Cardiac mass was measured by Doppler Echocardiography. Images of cardiac structures were taken using B-Mode and were then translated to M- Mode. The dimensions at the end …
-
Computational Approaches to Detect Pathogens in the Presence of Complex Backgrounds
… identification of pathogenic microorganisms in complex clinical and environmental samples is essential for the prevention and treatment of infectious diseases. The most sensitive and accurate detection approaches are based on the examination of the nucleic acid composition of the sample in order …
Page 1 of 8