Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Prdm16"”.
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Downregulation of Prdm16 Is Critical for HOXB4-mediated Benign HSC Expansion In Vivo
… involved in myeloid and B cell differentiation. Prdm16, a transcription factor associated with human acute myeloid leukemia (AML), was markedly repressed by HOXB4 but upregulated by HOXA9 and HOXA10, suggesting that Prdm16 downregulation was involved in preventing leukemia in HOXB4 transplanted …
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Unraveling the Interaction Between Beige Adipocytes and the Sympathetic Nervous System
… is established, we used an adipocyte-specific Prdm16 knockout mouse model to ablate beige adipocyte function and demonstrated that the density of sympathetic parenchymal innervation depends on the presence of functional beige adipocytes. These results suggest that communication between beige …
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Analysis of DNA methylation in canine osteosarcoma using next generation sequencing technology
… to those without. Notably, four genes (PRDM16, ADAMTS15, OPCML and NTM) display a difference in methylation status. Within all four genes, the methylation differences are observed within the introns. These genes were subject to further scrutiny using Nanopore data and RT-qPCR, where all …
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Metilación de histonas y fisura labio-palatina: asociación e interacción de variantes genéticas
… (EZH2, KDM1A, KDM6A, KDM6B, KMT2D, MECOM, PHF8, PRDM16, PRMT1, SETDB1, WHSC1) y el riesgo de FL/PNS en población chilena. La hipótesis planteó que variantes de estos genes representan elementos de riesgo para la aparición de fisuras labio/palatinas no sindrómicas. La metodología incluyó 249 casos …
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Novel genomic technologies and molecular diagnostics in Colorectal Cancer
… suppressors and oncogenes, such as A2BP1 and PRDM16 Finally, several copy neutral-loss of heterozygosities (CN-LOHs) were detected, more frequently on chromosome 7p and 22q. In conclusion, in this study some novel broad and focal copy number abnormalities (CNAs) and CN-LOHs were revealed in …
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EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… expression of brown adipocytes markers , such as PRDM16, CIDEA, UCP1, ELOVL3 and DIO2, and an induction of mitochondrial biogenesis, after MS275 administration. In parallel, adypocyte size appeared smaller respect to the adipocytes of the control group. In white adipose tissue, we observed an …
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Carnosic acid against insulin resistance and obesity. Investigating its effects on adipocytes.
… of browning protein markers (UCP-1, PGC-1α, PRDM16, TFAM) and mitochondrial biogenesis in an AMPK-dependent manner in 3T3- L1 white adipocytes. Conclusion: These studies demonstrate that CA has a pronounced potential in 1) attenuating the palmitate-induced insulin resistance in adipocytes and …