Global ETD Search
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Showing 1 to 3 of 3 for “"Prb2/p130"”.
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Anti-cancer Functions and Mechanisms of a pRb2/p130 Peptide Fragment
The spacer region of pRb2/p130 was reported to be able to inhibit the kinase activity of Cdk2. The region responsible for the inhibitory effect was further narrowed down to a 39-amino-acid sequence, which was named as Spa310. In this dissertation, the anti-cancer functions and mechanisms of Spa310 …
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Repression of E2F-4 Mediated Transcription and Growth by Hypophosphorylated pRb2/p130 in Human Prostate Cancer Cells
… retinoblastoma protein (pRb), and its homologues pRb2/p130 and p107, comprise a gene family which is central in maintaining appropriate cell proliferation and differentiation. The RB proteins bind to and modulate the activity of E2F transcription factors, by way of a unique binding motif termed …