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Showing 1 to 20 of 32 for “"PrPc"”.
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Cellular Prion Protein (PrPC): Identification and Characterization of Novel Interacting Partners
The cellular prion protein (PrPC) is highly conserved throughout the evolution of mammals. (What does this sentence mean? What do you mean by ``conserved´´? This protein was higly conserved during the evolution of mammals [pantera et al. 2009; Jiayu et al.2009] and the gene tree deduced from the …
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The subcellular trafficking of the prion protein: Characterisation of the function of the PrPc N-terminus
… of the non-pathogenic cellular prion protein (PrPc) into a infectious isoform denoted PrPSc. The latter therefore represents a pathogenic agent (prion) which does not contain nucleic acids. During biogenesis, PrPc undergoes posttranslational modifications with the addition of two N-linked …
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Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells
The host encoded cellular prion protein (PrPC) is an N-linked glycoprotein tethered to the cell membrane by a glycophosphatidylinositol (GPI) anchor. Under certain conditions, PrPC can undergo conversion into a conformationally-altered isoform (PrPSc) widely believed to be the pathogenic agent of …
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
… for NF2 patients. Cellular prion protein (PrPC), encoded by PRNP gene, is involved in tumour development by altering proliferation, adhesion, and survival in some cancers via focal adhesion kinase (FAK) /Src/ NFκB, cyclin D1 and p53 -proteins. Our group previously showed a strong elevation …
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Das zelluläre Prionprotein im Liquor cerebrospinalis von Patienten mit verschiedenen neurologischen Erkrankungen
… 129 detektiert werden. Signifikant niedrigere PrPc-Liquorkonzentrationen konnten in allen hier untersuchten neurodegenerativen Erkrankungen festgestellt werden. Dabei konnte eine Abhängigkeit der PrPc-Konzentrationen vom Schweregrad einer Erkrankung für die Gruppen CJK, AD, DLB und NPH …
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The role of the 37-kDa/67-kDa laminin receptor in the cellular metabolism of the prion protein
… Form (PrPSc) des zellulären Prion Proteins (PrPC) eine entscheidente Rolle spielt. PrPSc lagert sich im Gehirn von Menschen und verschiedenen Säugetieren zu langen Ketten, sogenanntem Amyloid, zusammen und bildet amyloide Plaques. Dies führt letzendlich zum Tod des Individuums. Die …
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Development and Application of a Novel Assay for Rapid Identification of Cellular Prion Protein Modulators
… pursued is to reduce cellular prion protein (PrPC) levels. Antisense oligonucleotides (ASOs) currently represent the only therapeutic strategy in clinical trials, showing promising potential, but further investigations are needed to assess their long-term efficacy. In parallel, the search for …
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Mechanisms of Prion Strain Interference
… abnormal isoform of an endogenous host protein (PrPC). Prion conversion involves a conformational change of PrPC into PrPSc, and this process may involve host polyanions such as ribonucleic acid (RNA). Conformational alterations in PrPSc are hypothesized to encode different prion strains, and the …
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Magnetic Resonance Imaging in the Assessment of Anti Prion Mediated Neurotoxicity In Vivo
The normal cellular prion protein (PrPc) plays a dual role in transmissible spongiform encephalopathies (TSE), which is a group of lethal disease affecting humans and a variety of animal species. First PrPC is hypothesized to be the source of the causative agent “the prion” in TSE, as the …
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„Ex vivo” Replikation des pathogenen Prion Proteins
… einer apathogenen zellulären Isoform (PrPC) in eine pathogene Isoform (PrPSc) verursacht. Diese Konformationsänderung kann entweder spontan oder induziert durch exogenes PrPSc erfolgen. Dabei kommt es zur Anlagerung von PrPSc an PrPC. Diese Erkrankung wirkt sich vor allem im Gehirn der …
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Probing Structural Differences of Recombinant Prion Isoforms Using Fluorescence Spectroscopy
… protein (PrP) from its normal, cellular isoform, PrPC, to an infectious, misfolded, fibrillar isoform, PrPSc, is responsible for various neurodegenerative diseases in a variety of mammalian hosts. Although the structure of PrPC is well studied, the structure of PrPSc is not known. Obtaining …
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Probing Structural Differences of Recombinant Prion Isoforms Using Fluorescence Spectroscopy
… protein (PrP) from its normal, cellular isoform, PrPC, to an infectious, misfolded, fibrillar isoform, PrPSc, is responsible for various neurodegenerative diseases in a variety of mammalian hosts. Although the structure of PrPC is well studied, the structure of PrPSc is not known. Obtaining …
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Application of copper isotope abundance measurements to study copper trafficking in vivo
… expression levels of the cellular prion protein (PrPC) could affect the distribution of copper isotopes in the body. Copper isotope amount ratios were measured in the liver, kidney, red blood cells, serum, and different regions of the brain of wild type, PrPC knockout, and mice in which the …
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Deciphering the Molecular Basis of the Species Barrier in Prion Disease Using Bank Vole PrP
… predominantly α-helical cellular protein called PrPC into a β-sheet rich conformer referred to as scrapie or PrPSc. The infectious nature of this conformer enables it to template the conversion of PrPC into additional copies of PrPSc, the efficiency of which depends on the sequence-encoded …
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Einfluss der Helix 1 und des β-Faltblattes auf die Aggregation des Prionproteins und seine Amyloidstruktur
… des nativen α-helikalen Prionproteins PrPC in seine pathologische Isoform PrPSc verursacht. In derzeitigen PrPSc-Strukturmodellen wird vermutet, dass die Helix 1 bevorzugt in ein β-Faltblatt bei der Aggregation des Prionproteins umfaltet. Diese Annahme wird durch die NMR-Struktur von …
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Characterization and targeting of the 2-methylcitrate cycle in Pseudomonas aeruginosa
… of three core enzymes: 2-methylcitrate synthase (PrpC), 2-methylcitrate dehydratase (PrpD) and 2-methylisocitrate lyase (PrpB). The 2-MCC presents itself as a potential target for therapeutic intervention in P. aeruginosa; in addition to its role in carbon fixation, it is also involved in …
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Identifizierung und Charakterisierung von Interaktoren des zellulären Prion-Proteins
… aus der apathogenen physiologischen Isoform PrPC gebildet. Dieses Protein wird vor allem in neuronalem Gewebe exprimiert und ist in allen Säugetieren hoch konserviert. Die Funktion des zellulären, apathogenen Prion-Proteins ist noch immer nicht geklärt, da Mäuse ohne dieses Protein gesund …
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Komplexe des Prion Proteins mit antiprional wirksamen Substanzen
… von zellulärem Prion Protein (PrPc) mit möglichen Wirkstoffen strukturell zu beschreiben. Die hierzu untersuchten Peptide und kleinen organischen Verbindungen, welche als antiprionwirksam beschrieben worden sind, interagierten aber nicht oder nur in einem Maß, welches eine …
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Effects of glycosylation on the structure and fibrillization of prion protein fragments
… now accepted that the structural transition from PrPc to PrPSc is the major event leading to transmissible spongiform encephalopathies. Although the mechanism of this transition remains elusive, glycosylation has been proposed to impede the PrPc to PrPSc conversion. Structural studies on …
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Studies within Fragment-Based Drug Discovery: Library Synthesis and Hit-to-Lead Optimisation
… campaign against 2-methylcitrate synthase (PrpC) from Pseudomonas aeruginosa identified several hit compounds based on an indole unit. Synthetic efforts were undertaken to elaborate these fragment hits to increase potency. The adopted strategy focused on growing the indole fragment towards …
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