Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"Poxviruses"”.
-
Genetic and phenotypic analysis of novel South African Avian poxviruses
Avian poxviruses are important pathogens of both wild and domestic birds and exhibit a large degree of intragenus diversity at a genomic level. These viruses are known to differ in growth characteristics (in vitro and in vivo), virulence, and cross-protection, with little known about the genomic …
-
A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
Vaccinia virus (VACV) is a member of the poxviridae, a family of viruses with large double-stranded, linear DNA genomes that replicate in the cytoplasm of cells. The genome of vaccinia encodes over 200 proteins, many of which have been shown to function as inhibitors of the innate immune response. …
-
Evolutionary History of Immunomodulatory Genes of Giant Viruses
… NCLDVs include many diverse groups, including Poxviruses, Asfarviruses, Iridoviruses, Mimiviruses, and Marseilleviruses. Poxviruses are perhaps the most well-studied; these viruses have 135-360 kbp genomes with about half of the genes encoding essential replication genes and the other half …
-
The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1
… protect humans against HIV-1 infections. Because poxviruses are being developed as vaccine vectors against a number of diseases, it is important to continue the search for novel poxvirus vectors, in particular, those that do not cross-neutralize one another. This thesis describes the preliminary …
-
Expression, Regulation And Processing Of Late Functions Involved In The Assembly Of Vaccinia Virions
Poxviruses are the most complex eukaryotic viral agents when considered in terms of size, morphology, and replicative strategy. Much of the life cycle of the prototypic member of this family, vaccinia virus, has been studied using metabolic inhibitors and, more recently, conditional-lethal …
-
The Role of the Complement System in Mousepox Infection
Poxviruses subvert the host immune response by producing immunomodulatory virulence factors, including a complement regulatory protein. Ectromelia virus provides a mouse model for human smallpox infection where the virus and the host's immune response have also co-evolved. Using this model, we …
-
Immunotherapy for murine glioma
… of tumor-specific T cells. Two oncolytic poxviruses, vvDD vaccinia virus and myxoma virus, were each engineered to express the fusion protein IL15Ra-IL15 and a fluorescent protein (YFP or tdTomato Red). Viral gene expression (YFP or tdTomato Red) was confirmed in the murine glioma line …
-
Meccanismi evolutivi dei parapoxvirus: caratterizzazione genomica di pseudocowpoxvirus e messa a punto di sistemi per lo studio delle ricombinazioni
The Poxviruses are a family of double stranded DNA (dsDNA) viruses that cause disease in many species, both vertebrate and invertebrate. Their genomes range in size from 135 to 365 kbp and show conservation in both organization and content. In particular, the central genomic regions of the …
-
Structure of the GP16 ATPase from the φ29 dsDNA packaging motor
… packaging in eukaryotic dsDNA viruses such as poxviruses, herpesviruses and adenoviruses. Encapsidation of bacteriophage φ29 DNA is driven by a phage-encoded molecular motor. This motor is powered by an oligomeric ATPase, gp16, or gene product 16, that converts energy obtained from ATP …
-
DNA comparisons of the two orthopoxviruses monkeypox and variola
… smallpox has been eradicated there are animal poxviruses which are closely related. It is desirable to measure the closeness of this relation to assess whether Variola virus could re-emerge as a complex mutant of an animal poxvirus. The most likely candidate is Monkeypox, which can produce …
-
Presentation of Recombinant Proteins in Modified Vaccinia Virus Ankara Extracellular Enveloped Virions
… campaign. Nowadays recombinant attenuated poxviruses gain importance as live carrier vaccines against different infectious diseases and in cancer therapy. The aim of this work was to develop recombinant viral vectors, for presentation of a foreign antigen on the surface of extracellular …
-
The Vaccinia Virus A56/Vcp Complex: Mechanism of Formation and Implications for Virulence
… this phenomenon to VCP homologs from other poxviruses. Mutagenesis shows that VCP binds to the 3rd cysteine (residue 162) of the ectodomain of A56. We also begin to show that viruses that cannot form the A56/VCP complex are attenuated in vivo, using a virus V where the N-terminal cysteine of …
-
Vaccinia Virus Binding and Infection of Primary Human Leukocytes
… reports of the direct interactions between poxviruses and primary human leukocytes (PHLs) are limited. We studied the specific molecular events that determine the VV tropism for major PHL subsets including monocytes, B cells, neutrophils, NK cells, and T cells. We found that VV exhibited an …
-
Characterization of the anti-viral effects inhibited by the vaccinia virus K1 protein
… variola virus, the causative agent of smallpox. Poxviruses encode many strategies to evade the host immune and anti-viral response. One such host anti-viral response, activation of the double-stranded RNA activated protein kinase (PKR) pathway, is important in sensing the presence of …
-
An investigation into the specific function of the vaccinia virus :13.8 kDa protein encoded by the N1L gene
… in the brain. An essential requirement of poxviruses for their replication is the energy molecule adenosine triphosphate (ATP). The supply of this molecule in the brain to support replication of a virus is limited due to the high-energy requirements and small energy reserves of this organ. …
-
An investigation into the specific function of the vaccinia virus 13.8 kDa protein encoded by the N1
… in the brain. An essential requirement of poxviruses for their replication is the energy molecule adenosine triphosphate (ATP). The supply of this molecule in the brain to support replication of a virus is limited due to the high-energy requirements and small energy reserves of this organ. …
-
Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
The Molluscum Contagiosum Virus (MCV) is a dermotropic poxvirus that strictly infects humans. MCV infections produce umbilicated lesions that can persist for six to nine months in children and young adults. Currently there is no cure for MCV infections. Recent evidence suggests that the …
-
Parapoxvirus: basi genomiche della patogenesi
… of PPV is still limited as compared to orthopoxviruses, especially vaccinia virus (VACV). The PPV genome displays a high G+C content and relatively small size for poxvirus. Coventional electron microscopy displays PPV virions with ovoid shape and slightly smaller in size than the brickshaped …
Page 1 of 2