Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Poxvirus"”.
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A Flagellin-Poxvirus Antigen Vaccine: Strengths and Limitations
… a robust antigen-specific humoral response to poxvirus antigens delivered intranasally (i.n.) or intramuscularly (i.m.), intramuscular immunization resulted in significantly high titers of anti-L1R and B5R IgG. Flagellin/poxvirus antigen fusion proteins were more potent than flagellin and L1R …
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Identification of genes from the poxvirus of a parasitoid wasp
<p>The Diachasmimorpha longicaudata entomopoxvirus (DlEPV) is a presently unclassified, insect-specific poxvirus. The virus was first identified in the accessory poison gland apparatus of a female parasitoid wasp, D. longicaudata. The wasp apparently injects DlEPV into host fly larvae along with …
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Immune responses against recombinant poxvirus vaccines that express full-length lyssavirus glycoprotein genes
… Here the use of two candidate host restricted poxvirus vaccine vectors were explored, particularly also in regard to oral innocuity. The construction, convenient isolation and use of a recombinant Lumpy skin disease virus (Neethling strain) expressing rabies virus glycoprotein in a mouse model …
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TRIM5α is a poxvirus restriction factor: viral evasion strategies and a pathway to antivirals
… highly conserved orthologues of C6 in other orthopoxviruses such as cowpox virus (CPXV), rabbitpox virus (RPXV), camelpox virus (CMLV), elephantpox virus, monkeypox virus (MPXV) clades I and II and variola virus (VARV), were shown to co-precipitate and degrade TRIM5α outwith infection. A …
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Poxvirus A51R Proteins Directly Bind to Microtubules to Antagonize Microtubule Dynamics, Intracellular Transport, and a Cell-intrinsic Antiviral Response
… facilitate their replication inside host cells. Poxvirus A51R proteins have been shown to colocalize with, and bundle, MTs, but the mechanisms of their MT interactions remained unclear. Additionally, vaccinia virus (VV), a model poxvirus, utilizes kinesin motor proteins on MTs to transport newly …
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Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
… uses an improved Modified Vaccinia Ankara poxvirus that we developed to express mesothelin to the murine immune system to treat pancreatic tumors and create an anti-cancer vaccine. PCR, Flow Cytometry, and Western Blot confirmed virus construction, purity, and protein expression. Our …
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Genetic and phenotypic analysis of novel South African Avian poxviruses
Avian poxviruses are important pathogens of both wild and domestic birds and exhibit a large degree of intragenus diversity at a genomic level. These viruses are known to differ in growth characteristics (in vitro and in vivo), virulence, and cross-protection, with little known about the genomic …
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In vitro characterization of the antiviral activity of Secomet V against vaccinia virus infections
The anti-poxvirus agent SECOMET V was the reference name for a plant extract produced in a bioreactor from primary plant stem cells, whose antiviral activity has been widely reported in folklore medicine. It exerted its anti-vaccinia virus activity by neutralizing cell-free virus rather than …
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Characterization of avipoxviruses for use in recombinant vaccines
… This work describes the first isolation of a poxvirus from Jackass penguins (Spheniscus dermersus) and the characterisation of the virus as a separate species of penguinpox virus.
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Modulating the Antigenicity and Immunogenicity of HIV-1 Envelope by a Conserved N-Linked Glycan
… a clinical HIV-1 vaccine could be elicited by a poxvirus prime-gp120 boost strategy in a rabbit model using Env with or without the N7 glycan. I demonstrate that immunized rabbits generated cross-reactive neutralizing activities against >50% of Tier 2 global HIV-1 isolates tested in addition to …
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New Roles for Mitochondria in Shaping Antiviral and Stress Responses
… amplify IFN-γ efficacy to restrict herpes- and poxvirus infection. In contrast, cells in galactose media display no differences in herpes- and poxvirus replication between untreated and IFN-primed conditions. However, overall herpes- and poxvirus replication is decreased in untreated cells grown …
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Development and characterisation of recombinant LSDV-vectored dual vaccines against bovine leukaemia virus and lumpy skin disease virus
… Secondly, the activity of five selected poxvirus promoters in cells infected with LSDV was assessed by the detection of transient expression of an enhanced green fluorescent protein (eGFP) reporter gene driven by the poxvirus promoters. The promoters tested were a modified early fowlpox …
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The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1
… protect humans against HIV-1 infections. Because poxviruses are being developed as vaccine vectors against a number of diseases, it is important to continue the search for novel poxvirus vectors, in particular, those that do not cross-neutralize one another. This thesis describes the preliminary …
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Characterization of the anti-viral effects inhibited by the vaccinia virus K1 protein
Vaccinia virus (VV), a member of the poxvirus family of double-stranded DNA viruses, is well-known as a highly effective vaccine against variola virus, the causative agent of smallpox. Poxviruses encode many strategies to evade the host immune and anti-viral response. One such host anti-viral …
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Investigation of local South African avipoxviruses as potential vaccine vectors
Avipoxviruses are large, genetically diverse DNA viruses which are particularly desirable for use as vaccine vectors as a result of their excellent safety profile and host range restriction. In this study, 8 novel South African (SA) avipoxvirus isolates were characterized. They could be divided …
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Differentiation into Effector Cells with Distinct Memory Fates: Contributions of Viral Dose and Functional Avidity
… of the effector response generated following poxvirus or LCMV infection, SLEC were of higher functional avidity than their MPEC counterpart. Over time however, SLEC exhibited a decrease in peptide sensitivity in mice infected with VV but not LCMV. The decrease in functional avidity in SLEC was …
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