Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Powder flow"”.
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In-line powder flow behaviour measured using electrostatic technology
Within solid-dose manufacturing processes, powder flow and powder triboelectrification are critical to the quality of the final product. Off-line testers do not simulate the shear and packing conditions that a powder would experience in-process and may be unreliable in predicting in-line flow and …
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A coupled DEM/CFD analysis of die filling process
This thesis reports numerical analyses of powder flow, mixing and segregation behavior during die filling in a vacuum and in air using an Eulerian-Lagrangian model, which employs a Discrete Element Method (DEM) for the particles and Computational Fluid Dynamics (CFD) for the air with a two-way …
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A STUDY ON PARTICLE SURFACE ROUGHNESS AND ITS IMPACT ON TABLET AND INHALER TECHNOLOGY
Powder flow is an integral component in pharmaceutical manufacturing. Various powder flow methodologies were examined and correlated with each other using lactose of various shape and size. In-die powder flow during tableting was studied using lactose particles of different surface roughness. …
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Experimental and numerical study of flow characteristics and segregation in flow enhanced systems
… materials, two major topics of importance are powder flow enhancement mechanisms and the flow characterization. This dissertation is involved with both of these topics. With respect to the powder flow enhancement, this study involves investigation of two types of flow enhancement methods. The …
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Development of a pressurized low-temperature tablet press for a carbon dioxide flash frozen ice confection
… design, and testing of a series of prototype powder-pelletizing devices for use with an ice confection powder produced using a CO2 spray freezing process. The device must function at a temperature of 233 K and at pressures of up to 12 bar(a) and must produce at least 500 pellets for use in …
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Development of a micro-feeder for cohesive pharmaceutical powders
… for oral medicines is the consistent feeding of powdered materials, as any variation in the feed stream directly affects the quality attributes of the final drug product. However, achieving consistent and accurate powder flow rates in micro-feeding has remained a challenge in the pharmaceutical …
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Development of a test protocol for industry to predict and optimise flow behaviour of blended powders utilising particle to bulk scale models
… materials has been always a problem for powder industry because formulators have difficulty in measuring, controlling and/or modifying the bulk flow properties of powders. A recently developed powder flow tester (PFT) by The Wolfson Centre for Bulk Solids Handling Technology, University …
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Theoretical and experimental investigation of particle interactions in pharmaceutical powder blending
… costs. Since particles are the basic unit of powder flow, a fundamental understanding of the crucial particle characteristics and particle interactions is essential for a good prediction and control of the blending process. In this work, inter-particle adhesion forces including van der Waals …
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The morphology of spray-dried particles
… degree of feed aeration, and drying temperature. Powder flow ability, particle and bulk density, particle-size, particle friability, and the retention of volatiles bear a direct relationship to morphological structure. Morphologies of multicomponent mixtures were complex, but the respective …
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The post-dehydration processing and the effects on the structural modifications and functionalities of milk protein powders
… in the physicochemical behaviours of dairy powders. Post-dehydration technology is widely used as an effective method to modify the structural properties and potentially improve the functionalities of dairy powder. In the present study, the dairy powders were firstly agglomerated by …
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Quenching of particle-gas combustible mixtures using the electric particulate suspension (EPS) method
… quenching distance measurement of combustible powder suspensions has been taken from concept to working prototype. The method is validated in both normal gravity and microgravity.</p> <p>Particle suspension concentration profiles were determined by either a moving single laser scan (in 1 g) or …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
… as well as improving the consistency of the powder flow while processing which result in with improved drug content with comparable sustained release profile to the marketed formulation. The key objectives of this dissertation chapters are: (1) to introduce HME as an efficient technique …
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Grewia polysaccharide gum as a pharmaceutical excipient
… a highly viscous dispersion with pseudoplasmic flow behaviour. The method by which drying is achieved can have significant effect on some physicochemical properties of the gum. Consequently, the intrinsic viscosity and molecular weight, and parameters of powder flow were shown to differ with the …
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Design of experiment analysis of high velocity oxy-fuel coating of hydroxyapatite
… the HVOF thermal spray process utilises only powder as the coating material rather than wire or rod. Carbon-hydrogen group of gases like propane, propylene, acetylene or even just pure hydrogen can be used as fuel gas in the HVOF process. In the Sulzer Metco Diamond Jet HVOF thermal spraying …
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Modelling of dosator filling and discharge
… products that are delivered to the customer in powder form (i.e. capsules and dry inhaled powder applications). However a significant problem for this technology is the ability to predict how accurately and reliably, new formulations can be dosed from these machines prior to scale-up for …
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Effect of dry particle coating on the properties of cohesive pharmaceutical powders
… have been previously shown to have improved flow and handling properties. The improvements in these properties can be applied and are very useful for a number of industrial applications, in this case the pharmaceutical industry. This work investigates the effect of dry particle coating to …
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Discrete element method based scale-up model for material synthesis using ball milling
Mechanical milling is a widely used technique for powder processing in various areas. In this work, a scale-up model for describing this ball milling process is developed. The thesis is a combination of experimental and modeling efforts. Initially, Discrete Element Model (DEM) is used to describe …
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The production of a lyotropic liquid crystal coated powder precursor through twin screw extrusion.
… to produce lyotropic liquid crystal coated powder precursor by exploiting Pluronic F127 thermoreversible gelation property to get powder precursor without granular aggregates or with less compacted granular aggregates. The highly soluble chlorpheniramine maleate loaded in Pluronic F127 …
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Particle engineering via surface modification during micronization for pharmaceutical applications
… downstream processing problems related to poor flow and dispersion properties. The importance of the flowability of pharmaceutical powders is well-documented in the literature. It is, therefore, important to develop a method that can simultaneously overcome these processing issues and allow for …
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Development of a Particle Flow Test for Rotational Molding
<p>One of the current testing method (the Dry Flow test) to qualify resin for use in production in the rotomolding process has been shown to have many flaws in both equipment and procedure. Research was done here to investigate a possible alternative that could eliminate some of these testing …