Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 50 for “"Potential therapeutics"”.
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Synthesis And Evaluation Of Novel Tropane Compounds As Potential Therapeutics For Drug Abuse
In an effort to search for potential therapeutic agents for cocaine addiction, a novel class of compounds was synthesized and evaluated for in vitro dopamine and serotonin transporter affinities. These unique 3ƒÀ-aryl-3ƒ¿-arylmethoxytropane analogues incorporated the structure of dopamine selective …
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Computational studies of biomolecules to explore potential therapeutics for COVID-19 and SAMD9- associated diseases
… continues to threaten public health. Various therapeutics that target proteins of the virus have been studied, which have shown some degree of success. Advancements in computational methods have offered an excellent opportunity to explore biological macromolecule conformations, functions, and …
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GENERATION OF SYNTHETIC ANTIBODIES AS POTENTIAL THERAPEUTICS TO BLOCK IL3–MEDIATED INNATE IMATINIB RESISTANCE IN CHRONIC MEYLOID LEUKEMIA
… was focused on generation of novel antibodies as therapeutics to block innate imatinib resistance in chronic myeloid leukemia (CML). Tyrosine kinase inhibitor (TKI), imatinib, is the standard therapy for CML. Although many patients respond to the conventional TKI chemotherapy, the majority relapse …
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Design and Synthesis of Inhibitors of Mycobacterium tuberculosis Menaquinone D (Mtb MenD) as Potential Therapeutics for Tuberculosis (Tb)
… bacteria. Menaquinone biosynthesis presents a potential target for therapeutic intervention, as it is not produced in humans. In this work, libraries of novel inhibitor candidates targeted at the essential enzyme MenD were designed, synthesized, and evaluated to explore the potential utility of …
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Pro-Angiogenic Self-Assembling Peptides
… biomaterials have been developed to function as potential therapeutics that promote the growth of new blood vessels. The analyses conducted on the lipidated peptides, which were designed to include a peptide sequence that promotes angiogenesis, include cytotoxicity, viability, and tube formation …
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Role of Bcl-2 proteins in neutrophil activation and delayed apoptosis in crystal-induced arthritis
… process in response to crystals could lead to potential therapeutics for crystal-induced inflammatory diseases.
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Isolation and identification of an antimicrobial peptide with high anticancer activity and selectivity, QUB-2584 from the skin secretion of Litoria caerulea
… derived from the frog skin secretion have the potential to be therapeutic drugs due to their bioactivities. Their various and complex structural classification, physical-chemical properties, and mechanism contributing to their bioactivities have been discovered and well understood. Here, we …
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Identification of Undifferentiated Human Embryonic Stem Cell-Specific Genes
… culture and differentiate these into cells of potential therapeutics.
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Synthesis of cis- and trans-3-fluoroacrylate, and inhibition of BCL6 targeting a non-reactive cysteine
… intermediate. In the second project, a potential inhibitor that targets the BTB-domain of BCL6 was made in a multi-step route. The compound builds on preliminary data that shows a “switchable electrophile” strategy can be used to selectively and irreversibly modify a cysteine within the …
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Modelling white matter pathology and establishing a novel ex-vivo platform for drug identification in neuroinflammation
… into some critical considerations and the potential future of modelling WM pathology. As well as identifying new potential therapeutics which may be successful in the preservation of WM clinically.
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Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
… ill-defined. Additionally, a limited range of therapeutics and the dismal prognosis of patients with advanced disease highlights a need for better understanding of the mechanisms that drive bladder cancer progression, in order to identify new avenues for therapy. The extracellular matrix (ECM) …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… oil 40 (HCO-40) and Octoxynol 40(OC-40) as a potential-therapeutics for AMD. Hydrophobic drugs such as curcumin (CUR), celecoxib (CXB), and resveratrol (RSV) were successfully solubilized and entrapped in the core of the nanomicelles. These nanomicellar constructs efficiently utilize their …
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The development of a rhodium-catalyzed chemo- and stereoselective hydroamination for the synthesis of 1,2-diamines
… reviewed. Herein, many marketed pharmaceuticals, potential therapeutics, and natural products bearing this motif of interest are discussed. Additionally, 1,2-diamines have been shown as ligands for catalysis. Due to this interest in the 1,2-diamine functionality, some current synthetic methods to …
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Mechanisms of Enzyme Neofunctionalization in Plant Specialized Metabolism
… and their derivatives have been explored as potential therapeutics. Moreover, the majority of plant natural product biosynthetic pathways remain inadequately studied, and the biocatalytic potential of their biosynthetic enzymes remains underexplored. In this thesis, we explore the molecular …
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Machine Learning Approaches for Characterizing ALS Disease Progression
… heterogeneity makes it challenging to identify potential therapeutics and to evaluate their effectiveness in slowing progression. At the same time, a better understanding of the heterogeneity of ALS might help identify environmental or genetic modifiers of disease that could be targeted …
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COMPARISON OF E. COLI AND Y. PESTIS LPS TLR4 TIME COURSE ON P388D1 MACROPHAGES USING FLUORESCENT CONJUGATED ANTIBODIES
… agents is necessary for development of potential therapeutics or preventative measures. Fluorescent probes and fluorescent microscopy are used to aid in the visualization of these components, but proteins associated with or spanning the cellular membrane are on the nanometer scale, …
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Romidepsin is a Potential Therapeutic to Treat Metastatic Osteosarcoma
… rate of only 25%. Therefore, our lab studied potential therapeutics to target lung metastases. To do this, our lab repurposed already FDA-approved oncology drugs, which saves on the extensive time and cost of traditional drug discovery. Our lab also used 3-D spheroids (sarcospheres) that mimic …
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Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons
… Disease (HD) are often used for testing potential therapeutic compounds. These experiments require substantial investments in time and resources, and have yet to produce any intervention that has made a significant impact on disease progression in the clinic. In evaluating potential …
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Singlet oxygen generating luminescent lanthanide complexes with naphthalimide-based and oligothiophene-based sensitizers
… data, the usefulness of these compounds as potential therapeutics with dual activity can be assessed and optimized. The complex with the highest luminescence efficiency for EuIII was [Eu(1Tdpa)3]3- (41.0%), for YbIII was [Yb1Thept(COO)4]- (0.50%), and for NdIII was [Nd2Thept(COO)4]- (0.45%). …
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Bundibugyo Versus Zaire Ebolaviruses: Examination of the Polymerase Complex as a Therapeutic Target
… efficiency with that of EBOV and to screen potential therapeutics. Through the exchange of polymerase complex proteins, it was found that EBOV could more readily accept proteins from another viral species than BDBV. In fact, use of the BDBV NP enhanced transcription of the EBOV minigenome, …
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