Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Potassium channels"”.
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Trafficking motifs in potassium channels
The pancreatic ATP-sensitive potassium (KATP) channels couple glucose metabolism to excitability of the pancreatic β-cells to regulate insulin secretion. The channel subunits, Kir6.2 and SUR1, are encoded by the KCNJ11 and ABCC8 genes respectively. Genetic polymorphisms in these genes, which reduce …
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Voltage-Gating Mechanism in Potassium Channels
"Voltage-gated potassium channels are membrane proteins that regulate the flow of K+ ions across the cell membrane. These channels respond to changes in electrostatic potential across the cell membrane, and allow passage of K+ ions through their conduction pore. In excitable cells, an interplay of …
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Voltage-Gating Mechanism in Potassium Channels
Voltage-gated potassium channels are membrane proteins that regulate the flow of K+ ions across the cell membrane. These channels respond to changes in electrostatic potential across the cell membrane, and allow passage of K+ ions through their conduction pore. In excitable cells, an interplay of …
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Membrane trafficking of ATP-sensitive potassium channels
ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is known how the number of channels at the cell …
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Interactions between potassium channels and serotonin in pulmonary arterial hypertension
… of the pulmonary vasculature. The activity of potassium ion (K+) channels plays a major role in influencing pulmonary artery tone by regulating resting membrane potential, intracellular Ca2+ concentration and contraction of vascular smooth muscle. This study aimed to investigate possible …
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Functional cell biology and molecular pharmacology of ATP sensitive potassium channels.
Adenosine triphosphate (ATP) sensitive potassium channels (K ATP) transduce changes in cellular metabolism into changes in membrane potential. Activation of K ATP channels causes vascular smooth muscle to hyperpolarize. This leads to a relaxation of the pre-contracted muscle. Inhibition of K ATP …
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Vascular Kv7 (KCNQ) Potassium Channels As Therapeutic Targets in Cerebral Vasospasm
… of calcium (Ca2+) through voltage-sensitive Ca2+ channels (VSCC) resulting in hyperconstriction (spasm). The spasm of the arteries restricts blood flow to the brain, inducing ischemic neurological deficits and consequential high morbidity and mortality. The cellular pathogenesis of cerebral …
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Potassium channels for high-frequency action potential generation in GABAergic interneurons of Rat Hippocampus
… that allowed me to investigate somatic ion channels under ideal voltage-clamp conditions, I started to examine the functional properties of Kv channels expressed in orien-alveus (OA) interneurons in the hippocampal CA1 region, a major class of dendritic inhibitory interneuron. The main …
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Action of halothane on large-conductance, calcium-activated potassium channels in rat cerebrovascular smooth muscle cells
… the opening of large conductance, Ca²⁺-activated potassium channels (BK channels) in cerebral artery smooth muscle cells. The present experiments utilized extra cellular patch clamp techniques to investigate whether clinically relevant concentrations of halothane directly alter the biophysical …
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The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.)
… role for inwardly-rectifying ATP-sensitive potassium (KATP) channels in the cardiac regulation of the fruit fly antiviral immune response, but no information is available on their role in the heart-specific regulation of bee immunity. The results of this work demonstrate that KATP channel …
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Investigating Cerebellar Mechanisms of Schizophrenia by Using a Pharmacological Mouse Model: Regulation of Voltage-Gated Potassium Channels
… affecting behaviour and cognition. Voltage-gated potassium (Kv) channels are fundamental to neuronal communication because of their intricate roles in regulating neuronal excitability, thereby governing information processing in the brain. The cerebellum has a significant influence over how this …
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Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
… onset of labor, and thus uterine contractility. Potassium currents play important roles in the regulation of contraction in many muscles, including cardiac and visceral smooth muscle. By virtue of their ability to set resting membrane potential and exert inhibitory effects, the alterations in …
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N-linked glycosylation of ether á go-go potassium channels: effects on cell surface expression and functional properties
Ether á go-go (Eag1) ist ein spannungsabhängiger Kaliumkanal, der offenbar an einer Vielzahl von zellulären Prozessen beteiligt ist. Die Ergebnisse dieser Arbeit zeigen, dass das Protein Eag1 aus Rattengewebe vorwiegend im Gehirn exprimiert wird. Dort unterliegt es der N-Glykosylierung, einer …
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Characterization of the Central Cavity of a Potassium Channel: Helix Dipoles, Conformational Plasticity and Inhibition
<p>Potassium channels are important for regulating the flow of potassium ions across semi-permeable cell membranes in an efficient and selective manner. Potassium channels form a conduction pore comprised of a selectivity filter responsible for the strong preference for potassium, and a …
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Adrenergic-cholinergic interactions in the heart
… is related to the ability of carbachol to open potassium channels. In rabbit left atria, carbachol exerted a direct negative inotropic response and inhibited the positive inotropic response to phenylephrine. Carbachol also promoted the efflux of 86 Rb in the presence and absence of phenylephrine …
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Calcium Regulation of a Slow AHP in Hippocampal Pyramidal Cells
… and involves activation of KCa3.1 and KCNQ potassium channels. Both KCa3.1 and KCNQ channels bind calmodulin (CaM) as a calcium sensor, with an additional role proposed for the protein hippocalcin. We measured the calcium sensitivity of the IsAHP and potassium channel associations with CaM …
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Mechanisms and plasticity of cold sensitivity in peripheral neurons
… receptor potential (TRP) family of cation channels are currently recognised as the principal transducers of thermal stimuli in sensory neurons, and two channels, TRPM8 and TRPA1, have been implicated in cold sensation. Ratiometric calcium imaging and quantitative rt-PCR studies revealed …
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Pharmacological and Pharmacokinetic Studies of a K<sub>Ca</sub>2.2 Positive Allosteric Modulator
<p>Small-conductance Ca<sup>2+</sup>-activated potassium channels (K<sub>Ca</sub>2.x) family is widely expressed in neurons, the heart, and endothelial cells. K<sub>Ca</sub>2.x channels are named small conductance Ca<sup>2+</sup>-activated potassium channels due to their comparatively low …
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Ion channels and electrical excitability in native murine anterior pituitary corticotrophs
… excitable cells with a number of ion channels and signaling pathways implicated in the control of their electrical properties and ACTH secretion. However, the mechanisms involved in native corticotrophs are poorly understood partly due to the current limitations of identifying …
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