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Showing 1 to 2 of 2 for “"Potassium Channels, Inwardly Rectifying"”.
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Understanding Potassium Homeostasis Using Human and Mouse Genetic Models
Potassium homeostasis is one of the most sophisticated processes involving multiple organs in mammals. Many physiological functions, such as excitability of muscles and neurons, rely on stable extracellular potassium concentration. To maintain potassium homeostasis, endogenous factors including …
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Regulation of Endocytosis of ROMK Channel by WNK Kinase Family
… and hyperkalemia. Renal outer medullary potassium channel (ROMK) is responsible for constitutive K+ secretion in the kidney. WNK1 and WNK4 stimulate the clathrin-mediated endocytosis of ROMK, which contributes to the pathogenesis of hyperkalemia in PHAII patients. Intersectin (ITSN) is a …