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Showing 1 to 20 of 74 for “"Posttranslational modifications"”.
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HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE
Covalent modifications of histones play a critical role in many important biological processes such as transcription, DNA repair and recombination. Among the major modifications known so far, histone H3 acetylation at lysines 9 and 14 (H3K9/14), monoubiquitination of histone H2B at lysine123 …
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Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
… MDCK-Zellen, konnte eine Vielfalt von posttranslationalen Modifikationen (O-Glycosylierung, Phosphorylierung und Sulfatierung) nachgewiesen werden, deren physiologische Bedeutung jedoch noch unklar ist. Die Substitution der putativen O-Glycosylierungsstelle von mIGFBP-6 durch einen …
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Genome mining for natural product biosynthesis: Amino acids, nonribosomal peptides, and ribosomal peptides with posttranslational modifications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Regulation of tumor necrosis factor-alpha induced apoptosis via posttranslational modifications in a human colon adenocarcinoma cell line
(cont.) phosphoproteomics technology, IMAC/LC/MS/MS, [approximately] 200 phosphosites were identified from HT-29 cells, some of which were detected only from insulin-treated cells. Our phosphoproteomics approach also enabled us to detect alteration of both known and unknown phosphorylation states …
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Regulation of Set1-Mediated Methylation of Dam1
… nucleosome. Histones are modified by a range of posttranslational modifications including methylation, phosphorylation, and ubiquitination, which are integral to a range of DNA-templated processes including transcriptional regulation. A hallmark for transcriptional activity is methylation of …
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A novel computational method for inferring dynamic genetic regulatory trajectories
… relationship between gene expression and histone posttranslational modifications during motor neuron development. In particular, the trajectories taken by the Hox genes through the space of regulatory states are characterized. Understanding the dynamics of Hox regulation is important because the …
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Histone Modifications in Trypanosoma Brucei
… ES. In other organisms, the role of histone posttranslational modifications (PTMs) in influencing transcriptional states has been well-documented. To begin to understand the role of chromatin structure in the regulation of gene expression in trypanosomes, I developed a protocol for the …
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Identification and Characterization of Enzymes Involved in Post-translational Modifications of Phycobiliproteins in the Cyanobacterium Synechocystis sp. PCC 6803
… and characterize enzymes responsible for posttranslational modifications of phycobiliproteins (PBP) in the cyanobacterium Synechocystis sp. PCC 6803. Asparagine 72 is methylated to produce gamma-N-methylasparagine on beta subunits of PBP in vivo. A candidate for this methyl transferase is …
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Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
… can be through protein-protein interactions and posttranslational modifications. A connection with eNOS and the cell cycle has begun to form with recent research identifying eNOS as a substrate of cyclin-dependent kinases (CDK). CDKs are one of the regulatory elements in cell cycle progression …
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Investigation of The Role of The Scaffold Protein Shc In Erk Signaling
… the combinatorial use of protein domains and posttranslational modifications. Using the scaffold Shc (Src-homology collagen-like) as a model system, we explored novel mechanisms whereby this class of protein shapes signaling output. In the present work, we focused on the role of Shc in the MAP …
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The structural characterization of the Saccharomyces cerevisiae alpha mating factor secretion signal for recombinant protein secretion in Pichia pastoris
… to high cell densities and provides complex posttranslational modifications. The most successful and commonly used secretion signal leader in Pichia pastoris has been the MAT α prepro secretion signal. However, limitations exist as some proteins cannot be secreted efficiently even with the …
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O-linked N-acetylglucosamine in differentiation and gene expression of mouse and human pluripotent stem cells
Peptide posttranslational modifications have been shown to regulate multiple aspects of cell signalling, thereby influencing cellular functions. The addition of O-linked Nacetylglucosamine to serine or threonine residues (O-GlcNAcylation) of proteins has only recently been characterized and its …
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Collagen-mimetic peptides for diagnosis and analysis
… in tissues to the significance of molecular modifications on its amino acid sidechains. This thesis explores the application of CMPs in diagnostic applications, in which CMPs detect aberrations in native collagen, and analytical contexts, in which CMPs act as a simplified system to understand …
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Characterization of the Roles of Intrinsically Disordered Regions from RNA-Binding Proteins in Phase Separation
… that are associated with aberrant mRNP granules. Posttranslational modifications of IDRs could modulate the assembly and disassembly of mRNP granules by altering the solubility of IDRs.
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The Substrate and Regulator of Acetyltransferase San
… acetylation is one of the most common protein modifications in eukaryotes and plays critical roles in numerous cellular events. San is an acetyltransferase required for proper chromosome segregation in Drosophila and human, but little is known about its substrates or upstream regulators. To …
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Fas-associated factor 1 is involved in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice
… functions of tau protein 4 E. Structure and Posttranslational Modifications of the Tau Protein 5 F. Distribution of tau phosphorylation sites and NFT formation in AD brains 7 G. Monoclonal antibody AT8 recognizes tau phosphorylation 11 H. Cholinergic dysfunction in the basal forebrain in AD …
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Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family
… enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs in the nucleus, such as in DNA damage repair and transcriptional regulation, had been well studied, functions for PARPs outside the nucleus …
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PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY
… transcription-promoting epigenetic histone posttranslational modifications (acetylation, methylation and ubiquitination) and inhibited the upregulation of plasticity-related gene, brain-derived neurotrophic factor (Bdnf). Furthermore, we found a novel non-traditional role of proteasomal …
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The Role of Tak1 In Pancreatic Cancer Development
… TAK1 inhibitors.</p> <p>In addition, several posttranslational modifications were identified in our study. The acetylation of lysine 158 on TAK1 is required for kinase activity. This site is conserved throughout all of kinase. Our findings may reveal a new mechanism by which kinase activity is …
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