Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Post-traumatic osteoarthritis (PTOA)"”.
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Biomechanical And Biological Evaluation Of A Model Of Post-Traumatic Osteoarthritis Following Noninvasive, Traumatic Rupture Of The Anterior Cruciate Ligament
<p>Post-traumatic osteoarthritis (PTOA) is a prevalent condition following rupture of the anterior cruciate ligament (ACL). While numerous animal models of PTOA exist, most are based on surgical disruption of a stabilizing structure. In the rat, surgical ACL transection is the most commonly …
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Understanding the Differential Effects of Dexamethasone on the Metabolism of Healthy and Diseased Articular Cartilage
… as a potential therapeutic to treat or prevent post-traumatic osteoarthritis (PTOA), a disease affecting millions of Americans without a disease-modifying drug. However, current reports on Dex efficacy often disagree on the effects of Dex on cartilage tissue homeostasis. The first part of this …
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Use Of synthetic solid scaffolds to mechanically support a chondrocyte-seeded peptide hydrogel for articular cartilage repair
Post-traumatic osteoarthritis (PTOA) is a subtype of OA associated with cartilage defects caused by traumatic joint injury. Because articular cartilage has a limited innate healing response, due to its avascular, aneural, and alymphatic nature, these defects lead to chronic degenerative joint …
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Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis
… promise as disease-modifying therapeutics for osteoarthritis (OA), a disease characterized by cartilage degradation. Additionally, dynamic loading has been demonstrated to affect chondrocyte metabolic activity, with mechanical stimuli acting as a therapeutic at specific amplitudes and …
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Optimization of overhead enclosure monitoring software in a rodent model of osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by pain, inflammation, and decreased range of motion, leading to impaired activities of daily living and reduced quality of life. OA affects between 250 and 500 million people worldwide, contributing to a substantial and sustained …
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Evaluating the Structural and Functional Consequences of Traumatic Joint Injury and their Relation to NF-κB in a Non-Invasive Model of Post-traumatic Osteoarthritis
<p>Post-traumatic osteoarthritis (PTOA) is a painful and debilitating disease of the synovial joint, characterized by degenerative changes to various joint tissues following traumatic joint injury. While several risk factors have been identified in the symptomatic progression of PTOA following …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
Post traumatic osteoarthritis (PTOA) refers to the progressive degradation of cartilage often triggered by a traumatic joint injury, such as a tear of the meniscus or anterior cruciate ligament (ACL). Such impact injuries lead to elevated levels of inflammatory cytokines in the synovial fluid of …