Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Post-traumatic Osteoarthritis"”.
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
Post traumatic osteoarthritis (PTOA) refers to the progressive degradation of cartilage often triggered by a traumatic joint injury, such as a tear of the meniscus or anterior cruciate ligament (ACL). Such impact injuries lead to elevated levels of inflammatory cytokines in the synovial fluid of …
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Longitudinal measures of lameness in an induced model of equine post-traumatic osteoarthritis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Cartilage stress relaxation induced by intra-tissue transport of cationic nanoparticles : implications for post-traumatic osteoarthritis drug delivery
… molecule for intra-articular injection of osteoarthritis (OA) therapeutics. Its nanoscale size and net positive charge make it a viable candidate for transport into and through articular cartilage, one of the most affected tissues in OA. Avidin has been shown to have a high uptake into and …
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Biomechanical And Biological Evaluation Of A Model Of Post-Traumatic Osteoarthritis Following Noninvasive, Traumatic Rupture Of The Anterior Cruciate Ligament
<p>Post-traumatic osteoarthritis (PTOA) is a prevalent condition following rupture of the anterior cruciate ligament (ACL). While numerous animal models of PTOA exist, most are based on surgical disruption of a stabilizing structure. In the rat, surgical ACL transection is the most commonly …
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Evaluating the Structural and Functional Consequences of Traumatic Joint Injury and their Relation to NF-κB in a Non-Invasive Model of Post-traumatic Osteoarthritis
<p>Post-traumatic osteoarthritis (PTOA) is a painful and debilitating disease of the synovial joint, characterized by degenerative changes to various joint tissues following traumatic joint injury. While several risk factors have been identified in the symptomatic progression of PTOA following …
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In vivo Knee Kinematics and Cartilage Recovery of Noncontact Anterior Cruciate Ligament Injuries
… programs have not significantly reduced these traumatic injuries, and debilitating repercussions (i.e. pain, meniscal degeneration, post-traumatic osteoarthritis) occur even after reconstructive or rehabilitative treatment. Therefore, the overall objectives of this dissertation are 1) to …
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Understanding the Differential Effects of Dexamethasone on the Metabolism of Healthy and Diseased Articular Cartilage
… as a potential therapeutic to treat or prevent post-traumatic osteoarthritis (PTOA), a disease affecting millions of Americans without a disease-modifying drug. However, current reports on Dex efficacy often disagree on the effects of Dex on cartilage tissue homeostasis. The first part of this …
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Use Of synthetic solid scaffolds to mechanically support a chondrocyte-seeded peptide hydrogel for articular cartilage repair
Post-traumatic osteoarthritis (PTOA) is a subtype of OA associated with cartilage defects caused by traumatic joint injury. Because articular cartilage has a limited innate healing response, due to its avascular, aneural, and alymphatic nature, these defects lead to chronic degenerative joint …
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Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis
… promise as disease-modifying therapeutics for osteoarthritis (OA), a disease characterized by cartilage degradation. Additionally, dynamic loading has been demonstrated to affect chondrocyte metabolic activity, with mechanical stimuli acting as a therapeutic at specific amplitudes and …
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Optimization of overhead enclosure monitoring software in a rodent model of osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease characterized by pain, inflammation, and decreased range of motion, leading to impaired activities of daily living and reduced quality of life. OA affects between 250 and 500 million people worldwide, contributing to a substantial and sustained …
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Nanomechanics of cartilage at the matrix and molecular levels
… (ECM) that occurs at the earliest stages of post-traumatic osteoarthritis? In this thesis, atomic force microscopy (AFM)-based oscillatory loading was employed in conjunction with finite element modeling to quantify and predict the frequency-dependent mechanical properties of articular …
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Lower Extremity Muscle Activation Following a Previous Knee Injury: Implications for Post-Traumatic Knee Osteoarthritis
… knee injury are at a high risk of developing post-traumatic knee osteoarthritis (PTOA) 10-20 years later. Compensatory activation patterns of knee muscles in response to the trauma may persist past the acute injury phase and result in abnormal mechanical loading and subsequent osteoarthritis …