Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"Post-transcriptional regulation"”.
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Post-transcriptional regulation of IgE
… kodiert. <br>In der vorliegenden Arbeit wird die postranskriptionelle Regulation der Expression von IgE im Vergleich zu anderen Isotypen untersucht. Das mRNA Expressionsmuster beider Formen der schweren Kette von IgE, s-epsilon (sekretorisch) und m-epsilon (membranständig), unterscheidet sich von …
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Transcriptional and Post-Transcriptional Regulation of Retroelements
… mechanisms in place to restrain retroelements. Transcriptional silencing of retroelements is mainly achieved by heterochromatinization and DNA methylation. Our lab has demonstrated that p53 can also transcriptionally repress retroelements, however, the mechanism by which p53 mediates repression …
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Oncogene-driven post-transcriptional regulation in lung cancer
… multi-omic methods to interrogate the regulation of gene expression and protein abundance in oncogenic KRAS and RIT1 cells. Quantitative proteomic and transcriptomic profiling revealed that both mutant KRAS and mutant RIT1 promoted canonical Ras signaling, and overexpression of …
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Post-transcriptional regulation of vibrio cholerae virulence activator toxt
… illness cholera, uses a complex array of gene regulation to induce its virulence determinants. During the early stage of infection, and upon response to unknown signals, virulence genes are turned on. ToxT protein is the primary virulence gene transcription activator. Once ToxT is produced, it …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… by increased progesterone receptor (PR) transcriptional activity, while spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and negatively impact PR function. In this study, we uncovered a new regulatory pathway …
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Stochastic Modeling of Gene Expression and Post-transcriptional Regulation
… processes are intrinsically stochastic, cellular regulation must be designed to control the`noise' in order to adapt and respond to changing environments. Another focus of this dissertation is to develop and analyze stochastic models of post-transcription regulation. The analytical solutions of …
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Transcriptional and post-transcriptional regulation in tissue regeneration and disease
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Post-Transcriptional Regulation of Maternal mRNA Shapes Early C. Elegans Embryogenesis
… to guide early embryonic development. The regulation of maternally provided factors is therefore critical and is a fundamental goal of developmental biology. During my studies, I investigated how two maternally provided mRNAs, zif-1 and mom-2, are regulated post-transcriptionally through …
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The Role of the ORB2 RNA-binding Protein in Post-transcriptional Regulation
… proteins (RBPs) are key components of the post-transcriptional regulatory framework and can determine the translational fate of their RNA targets. A wide variety of post-transcriptional regulatory mechanisms are employed during the early Drosophila embryo and it has been established as a …
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A Multi-Organ Role for Nocturnin in Post-Transcriptional Regulation of RNA
… study investigates Nocturnin's potential role in post-transcriptional regulation of mRNAs in the mitochondria and in two different tissues: brain and brown adipose tissue (BAT). Nocturnin has a predicted mitochondrial-localization signal (MLS) surrounded by two potential translation initiation …
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Transcriptional and Post-Transcriptional Regulation of Nodule-Specific Gene Expression in Soybean
… have not been compared. In addition, the role of post-transcriptional gene regulation during nodule development has not been thoroughly explored. Bridging these knowledge gaps is crucial to develop genetic/biotechnological strategies to optimize nutrient acquisition and sustainable production of …
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Post-Transcriptional Regulation of Virulence Genes by GlmY and GlmZ in Enterohemorrhagic E. Coli
… of the pedestal must be tightly regulated both transcriptionally and post-transcriptionally. The two two-component systems QseEF and QseBC have been previously shown to regulate various virulence genes. We established that these systems both regulate the transcription of the small RNA (sRNA) …
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Post-Transcriptional Regulation of Mammalian Gene Expression In Non-Coding Region of Target Rna
… regions (UTRs) of the TUSC2 gene in the regulation of TUSC2 protein expression. We found that two small upstream open-reading frames (uORFs) in the 5’UTR of TUSC2 could markedly inhibit the translational initiation of TUSC2 protein by interfering with the “scanning” of the ribosome …
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Mechanistic and physiological insights into post-transcriptional regulation by small RNAs SgrS and DicF
… small regulatory RNAs (sRNAs) are important post-transcriptional regulators of gene expression in bacteria. These sRNAs deploy novel mechanisms to regulate mRNA targets leading to various physiological outcomes during stress conditions including, but not limited to, iron starvation, carbon …
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Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis
… details. Through the study of epigenetics and posttranscriptional regulation of gene expression by high-throughput sequencing technologies in several biological processes, namely embryonic stem cells, somatic reprogramming, erythroid differentiation, epithelial-mesenchymal transition and cancer …
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Understanding the roles for CELF2 in post-transcriptional regulation for the fate of neural stem cells.
… The fate of NSCs are achieved by intrinsic gene regulation along with extrinsic environmental factors. As gene regulation is an essential process for all cells, understanding its coordination is important to understand how the fate of cells are determined. Gene regulation can occur at three main …
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Post-transcriptional regulation of poly(A) binding proteins direct multiple facets of cardiac development and hypertrophy
… of its mass. In mammals, cardiomyocytes become post-mitotic shortly after birth, and from this point on, the heart increases in size almost exclusively through cellular hypertrophy of existing cardiomyocytes in a process termed maturational hypertrophy. A key process during the progression to …
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INVESTIGATING POST-TRANSCRIPTIONAL REGULATION OVER MRNA FATE ACROSS THE MITOTIC-TO-MEIOTIC TRANSITION IN MALE GERM CELLS
… cell development. Although it is recognized that post-transcriptional control of mRNAs is essential for spermatogenesis, little is known regarding how differential utilization of mRNAs results in successful entry of male germ cells into meiosis. The review (Chapter II) and studies (Chapters …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the SPI1 regulatory circuit. The transcriptional regulator HilA activates the expression of the genes encoding the SPI1 T3SS structural and primary …
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