Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Post-transcriptional control"”.
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Post-transcriptional control of gene expression
… we explore several aspects of gene expression control by analyzing data from biological experiments. Most of the work following uses a common mathematical model framework based on Markov chain models to test hypotheses, predict system dynamics or elucidate network topology. Our work lies in the …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… study demonstrated that Nhlh2 could be regulated transcriptionally by both NFκB and Stat3 transcription factors and post-transcripitionally by the 3'UTR SNP that converts adenosine to guanine.
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Kinetics of accumulation of photoregulated plastid proteins and theirmRNAs during greening in Euglena gracilis Z
… between mRNA and protein suggests a strong post-transcriptional control on LSU gene expression. Expression of CP I and 26 kd and 28 kd LHCP genes appears subject to control in the nucleus up to 1 day. After this, post-transcriptional control appears to be important. The level of CP a (58 kd) …
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Regulation of proto-oncogenes and immune system genes during CSF-1-induced macrophage differentiation
… the molecular origin of macrophage diversity transcriptional and post-transcriptional regulation of genes involved in affector and effector functions were studied. Transcripts of c-fms and c-fos were detected at all stages of differentiation, whereas c-myc gene expression was highest during …
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INVESTIGATING POST-TRANSCRIPTIONAL REGULATION OVER MRNA FATE ACROSS THE MITOTIC-TO-MEIOTIC TRANSITION IN MALE GERM CELLS
… cell development. Although it is recognized that post-transcriptional control of mRNAs is essential for spermatogenesis, little is known regarding how differential utilization of mRNAs results in successful entry of male germ cells into meiosis. The review (Chapter II) and studies (Chapters …
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Deciphering tranSNPs: functional genetic variants shaping protein output and cancer-related phenotypes
… single-nucleotide polymorphisms (SNPs), on the post-transcriptional control of gene expression, to identify a novel class of functional SNPs, named tranSNPs, with potential applications as biomarkers for cancer diagnosis, prognosis, or targeted therapy; tranSNPs are defined as SNPs whose allelic …
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Network Analysis and Comparative Phylogenomics of MicroRNAs and their Respective Messenger RNA Targets Using Twelve Drosophila species
… non-coding RNA molecules which exert powerful post-transcriptional control over gene expression in eukaryotes. Indeed microRNAs likely represent the most abundant class of regulators in animal gene regulatory networks. This study describes the recovery and network analyses of a suite of …
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Analysis of the Role of EIF5A in Mammalian Translation
… growth-promoting gene that is subject to tight post-transcriptional control. However, the genes and mechanisms that mediate this regulation at the mRNA level are poorly understood. In order to identify regulators of MYC that function through the 5' UTR of the transcript, we performed a …
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Interrogations of protein and RNA: localisation, interactions and dynamics
… RNAs and proteins are fine-tuned by a set of. post-transcriptional and post-translational regulation mechanisms fundamental to complex cellular processes, throughout the stages of development or in response to acute stimuli. Whereas microscopy- or affinity-based methods are routinely employed …
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Characterization of Small Molecules Inhibiting the RNA Binding Protein HuR
… to therapeutically target the HuR mediated, post-transcriptional control in inflammation and cancer like anomalies.
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Investigating the Role of Muscleblind-Like 1 in the Suppression of Breast Cancer Progression
… the determinants of breast cancer progression. Post-transcriptional control of gene expression plays a central role in modulating transcriptional output. The interactions between messenger RNA cis-regulatory elements and trans-factors control coordinated gene expression states. …
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Investigation of global regulators influencing styrene metabolism and bioplastic synthesis in Pseudomonas putida CA-3
… of the role played by global regulators in controlling these pathways currently represents a critical knowledge gap in this area. Here we report on our efforts to identify such regulators using mini-Tn5 transposon mutagenesis of the P. putida CA-3 genome. The library generated was subjected …
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Microscopic characterization of a putative ER-membrane targeted Puf RNA-binding protein in Arabidopsis thaliana
… are the functional units that participate in post-transcriptional gene regulation activities. One group of RBPs that plays an important role in regulating cytoplasmic post-transcriptional control is the Puf family of RNA-binding proteins. Some of the general characteristics of plant Puf …
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Targeting transcriptional and translational mechanisms to enhance utrophin A expression as a therapy for Duchenne muscular dystrophy
… considerable interest to identify the mechanisms controlling utrophin expression in skeletal muscle, with the ultimate goal of identifying drugs that can stimulate utrophin levels in DMD patients. Utrophin A expression is regulated by transcriptional mechanisms that are associated with the slow …
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THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING
The homeostatic control of innate immunity is essential to health as dysregulation can lead to poor outcomes during infection or inflammatory conditions including autoimmunity. Interferon signaling is the specific antiviral arm of the innate immune system responsible for inducing interferons and …
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The PUF proteins in Trypanosoma brucei
… expression, which are mainly regulated at the post-transcriptional level. Proteins with an RNA-binding "Puf" domain are important for post-transcriptional control by modulation of mRNA stability and regulation of translation in other species. This suggested that Puf domain proteins might also …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… been extensively characterised for its role in post-transcriptional control of gene expression and is reported as a newly identified cancer driver gene. Replication stress (RS) threatens DNA replication fidelity and stability of the genome. Recently, a small number of AU-RBPs have emerged as key …
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Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum
… pathways, protein kinases are crucial for the control of proliferation and differentiation in other eukaryotes; we hypothesise that they play similar roles in P. falciparum. The life cycle of P. falciparum is complex, consisting of a series of tightly controlled stages of division and …
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