Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 414 for “"Post-transcriptional"”.
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Post-transcriptional regulation of IgE
… kodiert. <br>In der vorliegenden Arbeit wird die postranskriptionelle Regulation der Expression von IgE im Vergleich zu anderen Isotypen untersucht. Das mRNA Expressionsmuster beider Formen der schweren Kette von IgE, s-epsilon (sekretorisch) und m-epsilon (membranständig), unterscheidet sich von …
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Post-transcriptional control of gene expression
Gene expression describes the process of making functional gene products (e.g. proteins or special RNAs) from instructions encoded in the genetic information (e.g. DNA). This process is heavily regulated, allowing cells to produce the appropriate gene products necessary for cell survival, adapting …
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Transcriptional and Post-Transcriptional Regulation of Retroelements
… mechanisms in place to restrain retroelements. Transcriptional silencing of retroelements is mainly achieved by heterochromatinization and DNA methylation. Our lab has demonstrated that p53 can also transcriptionally repress retroelements, however, the mechanism by which p53 mediates repression …
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Oncogene-driven post-transcriptional regulation in lung cancer
… data suggest that in addition to widespread transcriptional changes, Ras signaling pathways in cancer promote post-transcriptional splicing changes that may contribute to oncogenic processes. In sum, I provided a baseline for how oncogenic KRAS and RIT1 affect the proteome and transcriptome …
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Post-transcriptional coordination by an RNA-binding protein
… and translation of their target mRNAs. Post-transcriptional regulation can orchestrate dynamic changes in gene expression, and can coordinate multiple cellular processes in response to various stimuli. Filamentous growth in Saccharomyces cerevisiae is a morphogenetic switch that occurs …
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Post-transcriptional regulation of vibrio cholerae virulence activator toxt
… lifestyle in the aquatic environment. While posttranscriptional regulation of ToxT has been observerd, most studies were focused on revealing how toxT expression is initiated. Here, the regulation of ToxT protein at the posttranscriptional level has been explored. </p> <p>In chapter one, …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… by increased progesterone receptor (PR) transcriptional activity, while spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and negatively impact PR function. In this study, we uncovered a new regulatory pathway …
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Stochastic Modeling of Gene Expression and Post-transcriptional Regulation
… is to develop and analyze stochastic models of post-transcription regulation. The analytical solutions of the models proposed provide insight into the effects of different mechanisms of regulation and the role of small RNAs in fine-tunning the noise in gene expression. The results derived can …
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Transcriptional and post-transcriptional regulation in tissue regeneration and disease
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Diverse RNA processing pathways important for post-transcriptional gene regulation
Cis-acting elements in 3' untranslated regions (UTRs) of mRNAs are crucial to the regulation of gene expression. Animal microRNAs (miRNAs) each target hundreds of mRNAs, which are recognized by pairing to nucleotides 2-7 of the miRNA. MicroRNAs mature through sequential RNase III cleavage of …
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Post-Transcriptional Regulation of Maternal mRNA Shapes Early C. Elegans Embryogenesis
… provided mRNAs, zif-1 and mom-2, are regulated post-transcriptionally through their 3’ untranslated region (3’ UTR) to ensure proper spatio-temporal protein expression. I discovered that seven RNA binding proteins bind directly to the zif-1 3’ UTR in a combinatorial fashion thereby ensuring that …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… study demonstrated that Nhlh2 could be regulated transcriptionally by both NFκB and Stat3 transcription factors and post-transcripitionally by the 3'UTR SNP that converts adenosine to guanine.
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The Role of the ORB2 RNA-binding Protein in Post-transcriptional Regulation
… proteins (RBPs) are key components of the post-transcriptional regulatory framework and can determine the translational fate of their RNA targets. A wide variety of post-transcriptional regulatory mechanisms are employed during the early Drosophila embryo and it has been established as a …
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A Multi-Organ Role for Nocturnin in Post-Transcriptional Regulation of RNA
… study investigates Nocturnin's potential role in post-transcriptional regulation of mRNAs in the mitochondria and in two different tissues: brain and brown adipose tissue (BAT). Nocturnin has a predicted mitochondrial-localization signal (MLS) surrounded by two potential translation initiation …
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Transcriptional and Post-Transcriptional Regulation of Nodule-Specific Gene Expression in Soybean
… have not been compared. In addition, the role of post-transcriptional gene regulation during nodule development has not been thoroughly explored. Bridging these knowledge gaps is crucial to develop genetic/biotechnological strategies to optimize nutrient acquisition and sustainable production of …
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The role of RNAi genes in Neurospora crassa post-transcriptional gene silencing
Meiotic silencing was first identified in the bread mold Neurospora crassa (by our group and others) and has since been discovered in worms, mice, and humans. Neurospora is an excellent model organism in that it is inexpensive, has a relatively small number of genes, and a rapid life cycle with two …
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Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
<p>Monoamines were first discovered at the end of the 19th century when William Bates identified epinephrine (EPI) and noted its hemostatic effects. During the 20th century, norepinephrine (NE), dopamine (DA), and serotonin (5HT) were discovered in both the periphery and the brain. Due, in part, to …
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Inferring Transcriptional and Post-Transcriptional Network Structure by Exploiting Natural Sequence Variation
… data and genotype data in order to identify transcriptional and post-transcriptional regulatory mechanisms. The data for these analyses comes from segregating populations of Saccharomyces cerevisiae (baker’s yeast) as well as Caenorhabditis elegans (roundworm). The first study focused on …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
… both innate and adaptive immunity. Early post viral infection, there is induction and secretion of IFN-β which alerts nearby cells and primes leukocytes for an immune response. A rapid response is necessary for effective control of virus replication and spread. Previously in our lab, the …
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