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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 25 for “"Post-mortem brain"”.

  1. Differential Proteomic Investigations Of Normal Appearing Gray Matter In Multiple Sclerosis And Control Post-Mortem Brain Tissue.

    Broadwater, Laurie A.Kent State University2013

    … c oxidase (COX) subunits 5a, 5b and 6c, the brain specific isozyme of creatine kinase, and hemoglobin ß-chain. A sixth differentially expressed protein identified was myelin basic protein (MBP), a major component of myelin. Lastly, glial fibrillary acidic protein was found to be …

    ohiolink Repository record

  2. The HLA Complex Group 9 Gene Modification Study in Major Psychosis

    Pal, Mrinal2015

    … group 9 (non-protein coding) gene (HCG9) in the post-mortem brain samples of individuals affected with schizophrenia (SCZ) and bipolar disorder (BPD). In this thesis we present results from bisulfite pyrosequencing based fine mapping of a ~700 bp region of HCG9 in 1,402 DNA samples from …

    toronto-retro Repository record

  3. Phosphoproteomics analysis of Alzheimer's disease

    Morshed, Nader Francis.Massachusetts Institute of Technology2021

    … neurofibrillary tangles, and inflammation in brain regions involved in memory. Despite numerous clinical trials, a limited understanding of disease pathogenesis has prevented the development of effective therapies. Several lines of genetic and biomolecular evidence indicate that AD progression …

    mit Repository record

  4. Effects of heat shock, hypoxia, post-mortem interval and glioma disease state on heat shock gene HSPA expression

    Beaman, Glenda MarieUniversity of Central Lancashire2012

    … conditions, in cancerous and non-cancerous brain tissue specimens from 18 patients (gliomas and normal conditions), and in post mortem rat brain samples exposed to heat shock. Three human glioma cell lines were chosen for this study, each representing various types of glioma: (astrocytoma, …

    cent-lancashire Repository record

  5. Investigating the neurological effects of SARS-CoV-2 infection on the brain

    Kabani, MalekMassachusetts Institute of Technology2023

    … Studying the molecular changes that occur in the brain upon infection and other cellular pathways that may be impacted will help us further understand the mechanism of neuroinvasion and what cell types are most vulnerable, in the hopes of developing therapies that target these markers. To this …

    mit Repository record

  6. Apolipoprotein E and propagation of pathological tau in Alzheimer’s Disease

    Davies, CaitlinThe University of Edinburgh2021

    … Pathological tau propagates through the AD brain in a defined manner, with indications this occurs trans-synaptically. Spread of pathological tau correlates with synapse loss and cognitive decline. Neuroinflammation, contributes to AD pathogenesis and is mediated by glia. Apolipoprotein E …

    edinburgh Repository record

  7. Epigenetic & transcriptomic alterations associated with childhood maltreatment, major depressive disorder, and post-traumatic stress disorder

    Bustamante, Angela CatherineUniversity of Illinois at Urbana-Champaign2017

    … developing major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) later in life. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a regulator of the body’s stress response, has been associated with exposure to childhood maltreatment, MDD, and PTSD. Additional …

    uiuc Repository record

  8. Harnessing transcriptomic data to better understand gene regulatory mechanisms of neurodevelopmental disorders

    Nawaz, Urwah2025

    … mechanisms by which their dysregulation impacts brain development remain unclear. Brain development depends on precisely timed, tightly regulated gene expression. This thesis investigates the nonsense-mediated mRNA decay (NMD) pathway —a key post-transcriptional mechanism with critical …

    adelaide Repository record

  9. Functional genomics studies of human brain development and implications for autism spectrum disorder

    Ziats, MarkUniversity of Cambridge2014

    … proper specialization and inter-connectivity of brain regions. Consequently, the dysregulation of complex gene networks in the developing brain is believed to underlie many neurodevelopmental disorders, such as autism spectrum disorders (ASD). Autism has a significant genetic etiology, but there …

    cambridge Repository record

  10. Investigating the role of protein aggregation in neurodegenerative diseases using super-resolution imaging

    Zuo, YukunUniversity of Cambridge2020

    … tissue accompanied by protein aggregation in the brain. Although identified as a leading pathology, the role of protein aggregates in the pathogenesis remains elusive. They are a highly heterogeneous population spanning from the fibrous forms visible in histology to the nanoscopic oligomers, both …

    cambridge Repository record

  11. The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons

    Harms, Ashley Nicole Simpson2010

    … of cytokines, including TNF, are elevated in post-mortem brain and cerebrospinal fluid of patients with PD. Previous studies from our group have shown that blocking solTNF signaling at the time of a unilateral 6-OHDA striatal lesion attenuated behavioral deficits and the acute loss of …

    utswmed Repository record

  12. New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis

    Stieren, Emily 1980-The University of Texas Medical Branch at Galveston2016

    … prevents the aggregation of APP. Examination of post-mortem brain tissue from AD revealed decreased ubiquilin protein levels, suggesting that the pathogenesis of late-onset AD is related to alterations in APP trafficking and quality control. Our results point to the restoration of ubiquilin …

    utmb Repository record

  13. Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis

    Kovacsics, Colleen Elizabeth2015

    … nervous system (CNS). Pathological studies of post-mortem brain parenchyma indicate productive HIV replication in brain macrophages/microglia and restricted infection in some astrocytes, while analyses of cerebrospinal fluid (CSF) suggest infiltrating T lymphocytes as another CNS HIV cellular …

    penn Repository record

  14. Investigation of the cellular tropism and in vivo distribution of HIV-1

    Newman, KirstyThe University of Edinburgh2005

    … of tropism, it is also possible to investigate post-mortem material from HIV infected individuals to characterize nature and cellular location of HIV variants. HIV can infect cells in the brain and this leads in some cases to HIV associated dementia (HAD). The presence of HIV in the brain poses …

    edinburgh Repository record

  15. Analisi dei profili di espressione dei microRNA: identificazione di biomarker nel suicidio

    NIOLA, PAOLAUniversità degli Studi di Cagliari2016

    … non-coding RNAs playing an important role as post-transcriptional regulators of gene expression. A growing body of evidence has shown that alterations in miRNA expression pattern are associated with several pathological processes. In particular, post-mortem brain studies support miRNA …

    cagliari Repository record

  16. The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders

    Keogh, MichaelUniversity of Cambridge2018

    … of exome sequencing and array genotyping on 1511 post-mortem brain samples within the MRC Brain Bank, we detected 61 monogenic cases of disease, 349 brains carrying disease risk factors, and identified that variants in GRN and PRPH may increase the risk of developing dementia with lewy bodies …

    cambridge Repository record

  17. Digital Morphometry : A Taxonomy Of Morphological Filters And Feature Parameters With Application To Alzheimer's Disease Research

    Mehnert, AndrewEdith Cowan University, Research Online, Perth, Western Australia1994

    … dementia associated with the degeneration of the brain. It "is the commonest type of dementia and probably accounts for half the dementia of old age" (Forsythe, 1990, p. 21 ). Post mortem examination of the brain reveals the presence of characteristic neuropathologic lesions; namely neuritic …

    edithcowan Repository record

  18. STRATEGIES TO TARGET HUMAN D-ASPARTATE OXIDASE AND MODULATE ENDOGENOUS D-ASPARTATE LEVELS IN SCHIZOPHRENIA

    CAVINATO, MIRIAMUniversità degli Studi di Milano2026

    D-aspartate (D-Asp) is abundant in mammal brain at embryonal level while it rapidly decreases at post-natal stages due to the enhanced activity of D-aspartate oxidase (DASPO). D-Asp participates to glutamatergic neurotransmission and alterations of physiological metabolism are linked to …

    milano Repository record

  19. The role of tau and neuroinflammation in Progressive Supranuclear Palsy and Alzheimer's Disease

    Vazquez Rodriguez, PatriciaUniversity of Cambridge2020

    … disease (AD) ‘in vivo’ and to validate it using post mortem data is critical to develop reliable biomarkers for these disorders, and for tracking the effects of clinical trials using disease-modifying therapies. The main aim of my PhD was therefore to assess the utility of the PET radiotracers …

    cambridge Repository record

  20. Characterisation of Tau splicing factors in Alzheimer’s disease

    Adelodun, AderonkeKing's College London2012

    … binding repeats respectively. In normal human brains the ratio of 4R/3R tau is approximately one. Aberrant E10 splicing is also observed in some <br/>sporadic AD cases as well as Pick’s disease.<br/><br/>The rationale for this study is that abnormal splicing may predispose to neurological …

    kings Repository record

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